Clinical trials: Coronary Physiology
Non-obstructive Coronary Artery Disease
Efficacy Study of Oral Nicorandil on Improving Microvascular Function in Female Non-obstructive Coronary Artery Disease (CAD) Participants
The study is a single-center, interventional, pilot study to evaluate the improvement of microvascular function by positron emission tomography (PET) after twelve-week treatment of oral nicorandil in female non-obstructive CAD…
- Trial name
- SPET (NCT03010423)
- Testing
- Nicorandil
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Liver Fat, Cardiac Function
Short-term Fat Overfeeding on the Effects of Liver Metabolism
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk.
- Conditions
- Liver Fat, Cardiac Function, Lipid Disorder, Adiposity
- Trial name
- FOS (NCT05962190)
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cardiovascular Injury, Prostate Carcinoma
Cardiac MRI in Measuring the Impact of Anti-androgen Treatment on Cardiac Function in Patients With Prostate Cancer
Learning about the impact of anti-androgen treatment has on cardiac function in patients with prostate cancer may help plan treatment and help patients live more comfortably.
- Trial name
- NCT02722525
- Testing
- Magnetic Resonance Imaging, Exercise Intervention, Perfusion Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Coronary Artery Disease
Effects of Aerobic Interval Training on Fatigue Level and Functional Performance in Post Angioplasty Patients
The goal of this randomized controlled trial is to determine the effects of aerobic interval training on levels of tiredness and functional performance in post-angioplasty patients.
- Trial name
- NCT06325189
- Testing
- Aerobic Interval Training
- Where
- Pakistan
- Volunteers
- 47 people
- Sponsor
- Riphah International University
Kidney Failure, Acute, Kidney Failure, Chronic
An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
Patients with abnormal kidney function are at increased risk for complications following heart surgery, including worsening kidney function possibly requiring dialysis, a prolonged stay in the critical care unit and hospital, and…
- Conditions
- Kidney Failure, Acute, Kidney Failure, Chronic, Cardiac Surgical Procedures
- Trial name
- NCT00122018
- Testing
- N-acetylcysteine, fenoldopam
- Volunteers
- 80 people
- Sponsor
- Linda F. Barr, M.D.
Acute Renal Failure
Carnitine, Aclycarnitine, Myocardial Function, and CRRT
Carnitine is essential for the transport of fatty acids into the mitochondria and energy production in different muscles, including the myocardium.
- Trial name
- NCT01941823
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Asha Moudgil
Stress
Time, Touch, Attention and the Autonomic Nervous System
The purpose of this study is to describe the onset, duration and dose-response of interpersonal mindful compassion on respiratory rate and heart rate variability in healthy adults in order to prepare for research evaluating the…
- Trial name
- NCT01428674
- Testing
- Interpersonal Mindful Compassion with Touch, Reading while extending loving kindness
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Pulmonary Hypertension, Right Heart Failure
RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation
Exercise training in Pulmonary arterial hypertension in the setting of rehabilitation leads to an enormous improvement of functional state and haemodynamics. However the underlying mechanism is still unkown.
- Conditions
- Pulmonary Hypertension, Right Heart Failure, Heart Failure, Contractility
- Trial name
- Reserve (NCT04188756)
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University of Giessen
Cardiovascular Diseases
Novel Strategies for Reducing Heart Disease Risk Disparities
This Western Pennsylvania-based study will (1) improve cardiovascular risk stratification to identify high-risk populations, (2) identify differences in cardiovascular risk, (3) evaluate mechanisms for population differences in…
- Trial name
- HeartSCORE (NCT00143923)
- Testing
- Nutrition, Exercise, Stress Management Counseling, usual care
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Turner Syndrome
The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome
The purposes of this study are to learn whether treatment with an androgen type hormone will improve the visual-spatial problems associated with Turner syndrome, and to evaluate the effect growth hormone, with and without…
- Trial name
- NCT00029159
- Testing
- estrogen, androgen
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Obesity, Surgery
Effect of Transpulmonary Pressure Guided Ventilation on Intraoperative Right Heart Function
The purpose of this clinical trial is to determine whether different types of ventilator settings during surgery change the relationship between the pressures in the lungs and the function of the heart.
- Conditions
- Obesity, Surgery, Anesthesia, Echocardiography, Transesophageal
- Trial name
- NCT05709041
- Testing
- Individualized lung-protective ventilation, Standard lung-protective ventilation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Vermont Medical Center
Diabetes-related Complications
Myocardial Regional Function by Dobutamine Stress Echocardiography in the Metabolic Syndrome and Type 2 Diabetes
Summary. Theoretical Rationale: The left ventricular myocardial performance results from a complex interplay between linear deformations (longitudinal, circumferential and radial) and twist/ untwist mechanics.
- Trial name
- NCT02505451
- Testing
- dobutamine
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Tricuspid Valve Insufficiency
Transcatheter Tricuspid Valve Interventions and Right Ventricular Function: Evaluation with Magnetic Resonance Imaging
There is an urgent need for transcatheter tricuspid interventions, as pharmaceutical therapy becomes ineffective in advanced disease stages and surgery remains associated with high mortality rates.
- Trial name
- NCT04522154
- Testing
- Magnet resonance imaging
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure
Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction
This was a randomized, double-blinded, placebo-controlled, multiple-dose study in subjects with stable heart failure (HF) with reduced ejection fraction (HFrEF).
- Trial name
- NCT02788747
- Testing
- 4 mg elamipretide, 40 mg elamipretide
- Where
- 15 sites in Italy, Netherlands and 1 more
- Volunteers
- 71 people
- Sponsor
- Stealth BioTherapeutics Inc.
PD1, Acute Myocardial Infarction
Comparison of PD1+T Cell Expression in Peripheral Blood for Cardiac Function Prognosis in Patients With Acute MI
Comparison of high PD1+ T cell and low PD1+ T cell expression in peripheral blood for cardiac function prognosis in Patients with acute myocardial infarction
- Trial name
- NCT05251987
- Testing
- PD1+ T Cell Expression
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Congenital Heart Defects
Using Tissue Doppler/Synchronization to Determine Heart Function in Children With Congenital Heart Disease
There are many children that have heart dysfunction because they are either born with Congenital Heart Disease (CHD) or developed poor heart function because their hearts are ill.
- Trial name
- NCT00208676
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Open Heart Surgery, Cardiovascular Disease
The Effect of Neurophysiological Facilitation Techniques on Health Parameters in Early Stages After Open Heart Surgery
In this study, researchers aimed to investigate effects of neurophysiological facilitation on functional capacity and respiratory parameters of patients who underwent open heart surgery.
- Conditions
- Open Heart Surgery, Cardiovascular Disease, Physiotherapy
- Trial name
- NCT06551714
- Testing
- Phase 1 cardiac rehabilitation, Neurophysiological facilitation techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Dogus Universitesi
Stable Angina Pectoris
Evaluation and Comparison of Several Point-of-care Platelet Function Tests in Predicting Clinical Outcomes in Clopidogrel Pre-treated Patients Undergoing Elective PCI.
The purpose of this study is to investigate whether the level of Platelet Inhibition as assessed with five point-of-care platelet function assays correlates with clinical (periprocedural) outcomes such as Acute Myocardial…
- Trial name
- NCT00352014
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- R&D Cardiologie
Diabetes
Walnut Ingestion in Adults at Risk for Diabetes: Effects on Body Composition, Diet Quality, and Cardiac Risk Measures
Proposed is a randomized, controlled, modified Latin square parallel design study with two treatment arms to examine walnut consumption effects on diet quality, body composition, and markers of cardiovascular risk in adults at…
- Trial name
- Walnut3 (NCT02330848)
- Testing
- Walnut Ad libitum diet, Walnut Calorie controlled
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Griffin Hospital
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