Clinical trials: Coronary Physiology
Left Ventricular Failure
Exercise in Patients With a Biventricular Pacemaker
The investigators will evaluate the effects of an exercise program (walking on a treadmill) on the physical performance, the cardiorespiratory function, the proclivity to heart arrhythmias and the quality of life of patients with…
- Trial name
- NCT00905944
- Testing
- Endurance exercise
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Charite University, Berlin, Germany
Cardiorenal Syndrome
Accuracy of Urinary NGAL in Predicting CardioRenal Syndrome in Acute Heart Failure at Emergency - CYNDERELA-HF Study
Rationale: Heart Failure (HF) elevated prevalence in Brasil and the world; 20-30% AHF patients develop CardioRenal Syndrome (CRS) type 1; Worsening Renal Failure (WRF) is a prognostic marker of mortality in Acute HF;NGAL is a…
- Trial name
- CYNDERELA-HF (NCT01364636)
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Pro-Cardiaco Hospital
Vasodilation
Effects of Exercise Training on Vascular Endothelial Function of Patients Submitted to Coronary Artery Bypass Graft
Objective: To observe the effects of exercise training on vascular endothelial function in patients undergoing coronary artery bypass graft (CABG) alone in phase III after six months of Cardiac rehabilitation programs (CRP).
- Trial name
- NCT02265107
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Universidade Federal do Rio Grande (FURG)
Coronary Artery Disease, Type 2 Diabetes
Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD)
The field of secondary prevention remains an extremely important goal for diagnostic and therapeutic approaches keeping in mind that 40% of all patients with acute myocardial infarction have prediabetes, commonly as impaired…
- Trial name
- NCT01035528
- Testing
- insulin glargine, metformin
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Munich Municipal Hospital
Heart Failure With Preserved Ejection Fraction, Iron Deficiency
IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency
This randomized, double-blind, placebo-controlled clinical trial evaluates intravenous ferric derisomaltose in older adults with HFpEF and iron deficiency.
- Trial name
- INFUSE-HFpEF (NCT07686692)
- Testing
- Ferric derisomaltose
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Platelet Function
Remote Ischemic Conditioning and Platelet Dysfunction
The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.
- Trial name
- NCT03125681
- Testing
- Remote ischemic conditioning, Control
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Renal Function Disorder, Hemodynamic Instability
The Effects of Dexmedetomidine on Early Stage Renal Functions in Pediatric Patients
The aim of this study is to evaluate the effect of dexmedetomidine infusion on early stage renal function.
- Trial name
- NCT01948336
- Testing
- Dexmedetomidine, Ketamine, Propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Mitral Regurgitation
The Effects of Degenerative Mitral Regurgitation on Cardiac Structure and Function, Symptoms, and Exercise Capacity
Current American College of Cardiology/American Heart Association guidelines recommend that patients with severe degenerative mitral regurgitation be considered for mitral valve surgery.
- Trial name
- NCT04051411
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Atlantic Health System
Right Heart Failure, Mechanical Ventilation
Effect of APRV vs. LTV on Right Heart Function in ARDS Patients: a Single-center Randomized Controlled Study
Acute Respiratory Distress Syndrome (ARDS) is often complicated by Right Ventricular Dysfunction (RVD), and the incidence can be as high as 64%.
- Conditions
- Right Heart Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome
- Trial name
- NCT05922631
- Testing
- Airway pressure release ventilation, low tidal volume
- Where
- China
- Volunteers
- 60 people
- Sponsor
- XiaoJing Zou,MD
MPS I, MPS IV A
Cardiac Structure and Function in MPS
The purpose of this study is to better understand how heart and blood vessel problems develop in people with Mucopolysaccharidosis (MPS).
- Conditions
- MPS I, MPS IV A, MPS - Mucopolysaccharidosis, MPS IVA
- Trial name
- NCT07361536
- Where
- 3 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Polymorphic Ventricular Tachycardia, Heart Failure
Radiofrequency Ablation for Polymorphic Ventricular Tachycardia With Heart Failure (RFCA for PMVT-HF)
This is a prospective, randomized, controlled trial to investigate the efficacy of radiofrequency catheter ablation (RFCA) combined with guideline-directed medical therapy (GDMT) compared to GDMT alone in patients with…
- Trial name
- NCT07130175
- Testing
- Radiofrequency Catheter Ablation, Guideline-Directed Medical Therapy (GDMT)
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Qian Feng
Postoperative Delirium, Cardiac Surgical Procedures
Dynamic Multimodal Delirium Warning After Cardiac Surgery
After heart surgery, up to half of all patients may develop a state of sudden confusion called postoperative delirium. This condition can lead to longer time on a breathing machine, extended stays in the intensive care unit…
- Trial name
- DEW-POD (NCT07686900)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southeast University, China
Cardiotoxicity, Childhood Cancer
Prediction of Delayed Toxic Cardiomyopathy in Children
Longitudinal analysis of myocardial function using "Speckle Tracking Echocardiography" STE analysis and prediction of delayed toxic induced cardiomyopathy in young patients who received anthracycline therapy in childhood.
- Trial name
- SpeckleAnthra2 (NCT05781672)
- Testing
- cardiac ultrasound with speckle tracking analysis
- Where
- France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Acute Coronary Syndrome
Continuous Clopidogrel Dose Adjustment in Acute Coronary Syndrome Patients With High On-treatment Platelet Reactivity
The purpose of this study is to determine whether continuous clopidogrel dose adjustment targeted after platelet function testing improves outcomes during 12 months of follow-up in acute coronary syndrome patients treated with…
- Trial name
- NCT02096419
- Testing
- Clopidogrel dose adjustment
- Where
- Croatia
- Volunteers
- 87 people
- Sponsor
- University of Zagreb
Cardiomyopathy
Speckle Tracking in Pediatric Patients
An echocardiogram, also called a cardiac ultrasound or echo, is a medical test that takes pictures of the heart using sound waves. It shows images of the structures of the heart without using radiation.
- Trial name
- NCT00489957
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Emory University
Cardiovascular Diseases
Chronic and Acute Effects of Smoking on the Left and Right Ventricular Relaxation in Young Healthy Smokers
Impairment of relaxation, the early phase of ventricular diastole is the first stage of heart diastolic dysfunction. Left ventricular diastolic function can be determined noninvasively by Echo- Doppler - derived mitral valve flow…
- Trial name
- NCT00395928
- Where
- Poland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Coronary Endothelial Function
Evaluate the Effect of Exenatide Treatment on Coronary Artery Endothelial Function
Type 2 diabetes mellitus (T2DM) is an important risk factor of cardio-cerebral vascular disease such as coronary heart disease. GLP-1 is a kind of incretin secreted by the L-cell located in Ileum.
- Trial name
- NCT02584075
- Testing
- Byetta (Exenatide), Glucophage ( Metformin Hydrochloride)
- Volunteers
- 100 people
- Sponsor
- Beijing Chao Yang Hospital
Coronary Artery Disease
Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)
The purpose of this study is to determine the effect of 6R-BH4 on vascular function in patients with coronary artery disease. We hypothesize that 6R-BH4 will improve vascular function in these patients.
- Trial name
- NCT00423280
- Testing
- 6R-BH4
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Oxford
Anemia
(ACORD Study) - A Study of NeoRecormon (Epoetin Beta) in Patients With Early Diabetic Nephropathy
This study will assess the effect of anemia correction with NeoRecormon on cardiac structure and function in patients with early diabetic nephropathy.
- Trial name
- NCT00354341
- Testing
- Epoetin beta
- Where
- 63 sites in Austria, Brazil and 15 more
- Volunteers
- 170 people
- Sponsor
- Hoffmann-La Roche
Heart Failure, Congestive
Renal Effects of Intrarenal Nesiritide
The impact of nesiritide in CHF is unclear, but it is possible that systemic vasodilation leads to adverse consequences even if the direct renal effects are positive.
- Trial name
- NCT00270829
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Maryland, Baltimore
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