Clinical trials: Coronary Physiology
Diabetes Mellitus, Coronary Disease
Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel
In recent years numerous studies have shown that the response of patients to the anti-platelet drug clopidogrel is widely variable.
- Trial name
- MATTIS-D (NCT01643031)
- Testing
- Ticagrelor, Continued clopidogrel
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Rabin Medical Center
Diabetes Mellitus Type 2, Diastolic Dysfunction
Effect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes Patients
The purpose of this study is to determine whether liraglutide a GLP-1 analogue are effective in the treatment of diastolic dysfunction in type 2 diabetes patients analyzed by cardiac MRI.
- Conditions
- Diabetes Mellitus Type 2, Diastolic Dysfunction, Cardiac MRI, Myocardial Perfusion
- Trial name
- NCT02655770
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Heart Failure With Preserved Ejection Fraction
Relationship Between Ambulatory Arterial Stiffness Index and Left Ventricular Diastolic Function in Patients With HFpEF
Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and…
- Trial name
- NCT05059769
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongying Zhang
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
Atrial Fibrillation, Atrial Function
Multi-Channel Esophageal ECG Signal Classification
This study is designed to prove new methods to enable the automated analysis of esophageal electrocardiography (eECG) signals in long-term measurements as well as the detection of atrial fibrillation.
- Conditions
- Atrial Fibrillation, Atrial Function, Arrhythmias, Cardiac, Atrial Premature Complexes
- Trial name
- MC-EECG (NCT02541175)
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obstructive Pulmonary Function, Restrictive Pulmonary Function
Study to Compare the Pharmacokinetics and Pharmacodynamics of ASA Powder for Oral Inhalation With Non-enteric-coated Chewable Aspirin in Adult Subjects With Obstructive or Restrictive Pulmonary Function
The goal of this clinical trial is to compare the pharmacokinetics (PK) pharmacodynamics (PD), safety and tolerability of acetylsalicylic acid powder for oral inhalation (I-ASA) with non-enteric-coated chewable aspirin (C-ASA) in…
- Trial name
- NCT05625347
- Testing
- single dose (100 mg) of ASA, single dose (162 mg) of non-enteric-coated chewable aspirin tablets
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vectura, Inc.
Gaucher Disease Type 3
Effect of Enzyme Replacement Therapy on Cardiac Function in Children With Gaucher Disease Type 3
all cases confirmed diagnosis of Gaucher disease type 3 recieving enzyme replacement therapy at Assiut university hospital
- Trial name
- NCT06627543
- Testing
- echo
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Noha Osman
Acute Kidney Injury, Renal Insufficiency, Chronic
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
This study evaluates the safety of iodinated contrast medium administered to liver transplant candidates with decreased renal function undergoing coronary CT angiography.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast-induced Nephropathy, Liver Transplantation
- Trial name
- NCT03806725
- Testing
- Intravenous administration of iodinated contrast medium for coronary CT angiography
- Where
- United States
- Sponsor
- Stanford University
Lymphoma, Sarcoma
WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring)
The purpose of this study is to find a cost effective cardiovascular (CV) surveillance of cancer survivors over long periods of time to prevent the risk of progression of heart failure (HF) and related morbidity and mortality.
- Trial name
- NCT07058064
- Testing
- Electrocardiogram, Echocardiogram, LVEF echocardiogram
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Mayo Clinic
Obesity
Effects of Exercise Mode on Cardiac Fat and Function
The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using…
- Trial name
- NCT03297333
- Testing
- Resistance training, Aerobic interval training
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Southern Illinois University Edwardsville
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiogenic Shock
Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function.
Long term prognosis of cardiogenic shock is related to the resolution of haemodynamic failure, associated visceral failure and the recovery of an adequate myocardial function.
- Trial name
- EMPASHOCK (NCT05879276)
- Testing
- Empagliflozin 10 MG
- Where
- 8 sites in France
- Volunteers
- 164 people
- Sponsor
- Central Hospital, Nancy, France
Pacemaker-Induced Cardiomyopathy, Tricuspid Regurgitation
Comparing the Effects of Newer Pacemakers and Their Effects on the Heart and Valve Function in the Short-term.
Conventional pacemakers involve placing a lead through a valve into the bottom right chamber of the heart. Research has shown that this approach is associated with an increased risk of valve dysfunction, mortality, and impairment…
- Conditions
- Pacemaker-Induced Cardiomyopathy, Tricuspid Regurgitation, Right Ventricular Dysfunction
- Trial name
- LvL-PACE (NCT07534917)
- Testing
- Temporary left bundle branch area pacing, Temporary leadless right ventricular pacing
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Heart Diseases, Lung Diseases
Heart and Lung Function Monitoring System
The investigator goal is to test a new device to see if it can provide continuous and simultaneous monitoring of heart and lung function.
- Trial name
- NCT02168049
- Testing
- Integrated CardioRespiratory System, Transthoracic Echocardiography (TTE), Electrocardiography
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes, Heart Failure
Optimized Glycemic Control in Heart Failure Patients With DM2:"Effect on Left Ventricular Function and Skeletal Muscle"
The investigators wish to investigate wether a more strict diabetic control improves cardiac function, muscle strength, exercise capacity and decreases symptoms.
- Trial name
- HFDM (NCT01213784)
- Testing
- all antidiabetic drugs will be appliable
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Primary Dysmenorrhea (PD)
Effects of Transcutaneous Tibial and Auricular Vagus Nerve Stimulation in Females With Primary Dysmenorrhea
Primary dysmenorrhea is a common gynecological condition characterized by painful menstrual cramps that can negatively affect daily activities and quality of life.
- Trial name
- NCT07834658
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS), Transcutaneous Auricular Vagus Nerve Stimulation (TaVNS), TTNS+TaVNS
- Volunteers
- 66 people
- Sponsor
- Riphah International University
Dilated Cardiomyopathy
Exercise Stress MRI to Evaluate Aortic Function (Compliance, Distensibility, Pulse Wave Velocity) and Left Ventricular Function : Validation in Healthy Volunteers and in Selected Patients. A Pilot Study.
Detecting abnormalities in the left ventricular mechanical and hemodynamic response to the stress of exercise may offer early diagnostic indicators in patients suffering from valvular disease such as mitral regurgitation.
- Trial name
- NCT02018835
- Testing
- MRI, cardiac echography transthoracic
- Where
- France
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Worksite Health Promotion, Lifestyle Risk Reduction
Intervention to Increase Physical Activity and Wellbeing Among Staff and Residents in Assisted Living Facilities
The purpose of the study is to test a program that aims to help staff increase wellness behaviors and test the impact of this program on staff and work outcomes.
- Conditions
- Worksite Health Promotion, Lifestyle Risk Reduction, Occupational Burnout, Healthcare Workers
- Trial name
- WHHIP+FFC 2026 (NCT07785947)
- Testing
- WHHIP, FFC
- Where
- United States
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Chronic Heart Failure
Acupuncture on Cardiac and Autonomic Function in Human Heart Failure
Acupuncture treatment may improve the cardiac function and the quality of life in heart failure patients. These effects may be related to the inhibition of sympathetic activity and/or increased vagal function.
- Trial name
- NCT01804816
- Testing
- Acupuncture, No Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The Cleveland Clinic
Coronary Heart Disease, Hyperlipidemia
Effect of Fenofibrate on Endothelial Function and High-density Lipoproteins (HDL)in Patients With Coronary Heart Disease
Fenofibrate is a drug that acts on the PPAR alpha receptors, increasing HDL-cholesterol and decreasing triglyceride levels. The interaction with these receptors has antiatherogenic actions by regulating the expression con key…
- Trial name
- NCT00552747
- Testing
- fenofibrate
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- National Heart Institute, Mexico
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