Clinical trials: Coronary Physiology
Lymphatic Insufficiency, Heart Failure
Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.
- Conditions
- Lymphatic Insufficiency, Heart Failure, Edema
- Trial name
- LYMTRIVA (NCT04595448)
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ischemic Cardiomyopathy
Intracoronary or Intravenous Infusion Human Wharton' Jelly-derived Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy
The purpose of this study is to investigate the safety and efficacy of intracoronary or intravenous infusion human umbilical Wharton's jelly-derived Mesenchymal Stem Cell (WJMSC) in patients with ischemic cardiomyopathy secondary…
- Trial name
- WJ-ICMP Tria (NCT02368587)
- Volunteers
- 160 people
- Sponsor
- Navy General Hospital, Beijing
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training.
- Trial name
- Calcicard (NCT01014611)
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Congenital Heart Disease
Theophylline Effects in the Fontan Circulation
A single group treatment phase 2 single-arm no-masking study to assess safety and efficacy of a short-term oral treatment with theophylline (ATC-no.
- Trial name
- THIEF (NCT05717049)
- Testing
- Theophylline Tablets
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Coronary Artery Disease
Platelet Function Assessment for Atherothrombotic Patients
Background-Despite the pivotal pathogenic role of platelets in atherothrombosis has been widely recognized, there is a striking lack of consensus regarding how to measure platelet function and how to monitor the effects of…
- Trial name
- NCT00513149
- Testing
- Clopidogrel
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Physiologic Changes, Exercise
Chrysin Exercise Performance Pilot Study
This single-arm pilot study evaluates within-subject changes in aerobic capacity, heart rate responses, cycling power output, and related physiological measures in healthy adults during and after 30 days of supplementation with a…
- Conditions
- Physiologic Changes, Exercise, Physiological Changes (Heart Rate)
- Trial name
- NCT07872111
- Testing
- Chrysin LipoMicel
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Isura
Heart Failure
Evaluation of Myocardial Improvement in Patients Supported by Ventricular Assist Device Under Optimal Pharmacological Therapy
Cardiac function may improve in patients with end-stage heart failure who receive long-term support with ventricular assist devices (VAD).
- Trial name
- NCT00402376
- Testing
- Pravastatin, Carvedilol, Perindopril, Biventricular assist device (Thoratec paracorporeal assist device)
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
AV Block
Atrioventricular Optimization for Dual Chamber Pacemaker
This study aims to examine the effect of atrioventricular synchrony in AV block patients who received permanent pacemaker. By achieving physiologic ventricular diastolic filling, adjustment of atrioventricular delay of pacemaker…
- Trial name
- NCT03556189
- Testing
- Case management
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yong Seog Oh
Respiratory Distress Syndrome
Effect of Different Ventilatory Strategies on Cardiac Function in Patients With Acute Respiratory Failure
Mechanical ventilation with low tidal volume (about 6 ml.kg-1) reduces mortality in ALI/ARDS patients respect to high tidal volume ventilation (about 12 ml.kg-1).
- Trial name
- VITALI (NCT00713713)
- Testing
- Mechanical ventilation with low and high tidal volume
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Exercise
Ischemic Preconditioning in Endurance Athletes
The aim of this study is to investigate the effect of remote ischemic preconditioning on biochemical and functional indices of cardiac function induced by a 30 km run in healthy trained long distance runners.
- Trial name
- NCT01774461
- Testing
- Remote ischemic preconditioning
- Where
- Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heart Failure, Congestive, Cardiovascular Diseases
Effects of Exercise Training on Diastolic Heart Function in Postmenopausal Women
This study is a prospective follow-up study to the Dose-Response to Exercise in Women (DREW) study. In DREW, 450 overweight, sedentary postmenopausal women were randomly assigned to either a non-exercise control group or to 1 of…
- Trial name
- NCT00125476
- Testing
- Exercise
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Healthy Adults
Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function in Patients With Stroke
This study aims to compare the effects of mirror therapy combined with either neuromuscular electrical stimulation or binaural beat stimulation on post-stroke lower limb motor function recovery.
- Trial name
- NCT06011018
- Testing
- Mirror Therapy, Mirror Therapy + Electrical Stimulation, Mirror Therapy + Binaural Beat
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Disorder of Pacing Function
3D Echocardiographic Assessment of Epicardial Pacing After Cardiopulmonary Bypass.
This study evaluates the usefulness of 3D echocardiography to guide pacemaker therapy in the operating room in cardiac surgical patients. Each patient will serve as his own control, following a paired design.
- Trial name
- NCT02842762
- Testing
- Right ventricular epicardial pacing, cardiac surgery, 3D TEE
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Suzanne Flier, MD
Premature Infants, Patent Ductus Arteriosus
Ibuprofen and Renal Function in Premature Infants
Purpose of the study: 1. To evaluate renal function maturation within the first month of life in very premature infants. 2. To determine whether a treatment with Ibuprofen for patent ductus arteriosus would alter renal function…
- Trial name
- NCT00217191
- Testing
- Ibuprofen
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- Maternite Regionale Universitaire
Delirium, Condition
Different Anesthetic Strategies on Postoperative Cognitive Function and Delirium in Patients Undergoing Cardiac Surgery
This is a prospective, multi-center, double-blind, randomized clinical trials.
- Conditions
- Delirium, Condition, Anesthesia
- Trial name
- NCT04505059
- Testing
- Precision cardiac anesthesia, Conventional cardiac anesthesia
- Where
- 3 sites in China
- Volunteers
- 502 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiac Function and Hemodynamics
Cardiac and Vascular Responses to Creatine Supplementation in Elderly Men
The purpose of this study is to investigate the impact of creatine supplementation alone or in combination with a moderate session of physical activity on vascular reactivity and heart hemodynamics in elderly men.
- Trial name
- NCT05329480
- Testing
- Creatine Monohydrate, Maltodextrin
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radford University
Cardiac Disease
Cardiac Deformation: Correlation With Conventional Echocardiographic Hemodynamic Variables (An Intraoperative Study)
The aim of this research is to apply cardiac tissue characterization in order to assess left ventricular function in cardiac surgical patients pre and post cardiopulmonary bypass.
- Trial name
- NCT00874991
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Weill Medical College of Cornell University
Stroke, Cardiovascular Stroke
Exer-gaming on Upper Extremity Function and Activities of Daily Living in Sub-acute Stroke Patient.
Stroke is one of the leading cause of death, in adult stroke causes permanent disability. Stoke impact the life of a person significantly including the quality of life of an individual and especially performing the task of daily…
- Conditions
- Stroke, Cardiovascular Stroke, Cerebrovascular Accident
- Trial name
- NCT04750746
- Testing
- Control group, Experimental Group
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Coronary Artery Bypass Graft Surgery Patients
Improving Outcomes and Quality of Life After CABG
The principal objective to this randomized trial is to compare the efficacy of two strategies of intra-operative hemodynamic management during cardiopulmonary bypass among patients undergoing primary elective coronary artery…
- Trial name
- NCT00256620
- Testing
- Mean arterial pressure during cardiopulmonary bypass 80 mmHg vs. customized
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- Weill Medical College of Cornell University
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
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