Clinical trials: Coronary Physiology
Chronic Kidney Diseases
Influence of Renal Function on the Circadian Variation of Cardiac Troponin
Cardiac troponin is the preferred biomarker for the diagnosis of acute myocardial infarction. Whereas the diagnosis is based on an increase and/or decrease in the concentrations of cardiac troponins with at least one value above…
- Trial name
- NCT02210897
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Cardiac Physiology, Cardiac Output
The Feasibility and Accuracy of Exhaled CO2 to Measure Cardiac Output in Ventilated Patients Without Tracheal Intubation
The purpose of this study is to test the accuracy of a new noninvasive way to measure how much blood our heart pumps per minute.
- Trial name
- NCT00783679
- Testing
- NICO device
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation
Is Endothelial Function a Predictor of Successful Ablation Therapy Provided to Patients With Atrial Fibrillation?
The purpose of this study is to assess whether normal endothelial function in patients with Atrial Fibrillation undergoing ablation procedure increases the chances of a favorable clinical outcome and maintaining sinus rhythm…
- Trial name
- NCT02129842
- Where
- 6 sites in United States, Germany and 2 more
- Volunteers
- 150 people
- Sponsor
- Itamar-Medical, Israel
Percutaneous Coronary Intervention, Myocardial Ischemia
Analysis of Myocardial Layer Specific Systolic and Diastolic Function During and After PCI
Investigators will analyzed systolic and diastolic function during and after ischemia induced by percutaneous coronary intervention.Also will be analyzed a local work index during acute ischemia induced by percutaneous coronary…
- Conditions
- Percutaneous Coronary Intervention, Myocardial Ischemia, Anginal Pain
- Trial name
- PCI-Strain (NCT02004483)
- Testing
- Percutaneous Coronary Intervention
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- RWTH Aachen University
Cardiovascular Risk Factors
A Study of Different Types of Fatty Acid on Risk Factors for Heart Disease
Experimental elevation of non-esterified fatty acids (NEFA) impairs endothelial function and insulin sensitivity but the impact of NEFA composition is unknown.
- Trial name
- eFAIRE (NCT01351324)
- Testing
- Absence or presence of fish oil
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Reading
Heart Failure, Valvular Heart Disease
Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort II: Structural Heart Interventions (PLUTO-II)
The aim of PLUTO-II is to use biventricular pressure-volume (PV) loop measurements to improve the understanding of direct changes in cardiac and hemodynamic physiology induced by transcatheter aortic valve implantation (TAVI) or…
- Conditions
- Heart Failure, Valvular Heart Disease, Aortic Stenosis, Mitral Insufficiency
- Trial name
- PLUTO-II (NCT06204783)
- Testing
- Pressure volume (PV) loop measurement
- Where
- Netherlands
- Volunteers
- 157 people
- Sponsor
- Erasmus Medical Center
Healthy Participants, Reference Values
Cardiac Normal Values Assessed by Magnetic Resonance Imaging
This study carried out a study enrolled healthy volunteers to comprehensively provide age and sex specific reference values of the normal cardiac structure and function of Chinese adults, using the steady-state free precession…
- Trial name
- NCT05346094
- Testing
- No intervention
- Where
- China
- Volunteers
- 938 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Diabetes Mellitus, Type 2
Effect of the Antidiabetic Drug Dapagliflozin on the Coronary Macrovascular and Microvascular Function in Type 2 Diabetic Patients
Cardiovascular events remain a major driver of morbidity and mortality in patients with type 2 diabetes mellitus. Diffuse coronary atherosclerosis, combined with impairment of the microcirculation are frequent even in…
- Trial name
- DAPAMICRO (NCT05392959)
- Testing
- Dapagliflozin 10 mg Tab
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Heart Failure
Evaluation of the Effect of Human Recombinant Growth Hormone in Patients With Advanced Heart Failure
Prospective randomized, placebo controlled, clinical trial to evaluate the effect of human growth hormone supplementation compared with placebo to patients with severe heart failure for a duration of 6 months on exercise…
- Trial name
- NCT00182169
- Testing
- Human recombinant growth hormone
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Postoperative Atrial Fibrillation
Microvascular Effects of Intravenous Esmolol During Postoperative Atrial Fibrillation
Background: Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy by using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic…
- Trial name
- FANI (NCT03646773)
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Type 2 Diabetes, Ketone Body Metabolism
Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function
This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo supplement (made with standard food ingredients that do not contain ketone…
- Conditions
- Type 2 Diabetes, Ketone Body Metabolism, Ketones, Metabolism
- Trial name
- NCT06078683
- Testing
- Ketone Ester Acute
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Chronic Kidney Disease
Effects of a Reduction in Kidney Function on Cardiovascular Structure and Function: A Prospective Study of Kidney Donors
Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death.
- Trial name
- NCT01028703
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Pulmonary Arterial Hypertension
Cardiac Function and Exercise Capacity in Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension is characterized by a progressive increase in pulmonary vascular resistance inducing shortness of breath and exercise intolerance.
- Trial name
- FONCE-HTAP (NCT02579954)
- Testing
- Rehabilitation
- Where
- 10 sites in France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Modes of Exercise and Myocardial and Endothelial Function, Microcirculation
Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study
The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. The researchers aim to investigate the beneficial effects of regular well-dosed exercise on health and…
- Conditions
- Modes of Exercise and Myocardial and Endothelial Function, Microcirculation, Subclinical Endorgan Damage, Obesity
- Trial name
- MMS (NCT00500773)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Cardiovascular Diseases
Novel Strategies for Reducing Heart Disease Risk Disparities
This Western Pennsylvania-based study will (1) improve cardiovascular risk stratification to identify high-risk populations, (2) identify differences in cardiovascular risk, (3) evaluate mechanisms for population differences in…
- Trial name
- HeartSCORE (NCT00143923)
- Testing
- Nutrition, Exercise, Stress Management Counseling, usual care
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Heart Failure, Chronic Heart Failure
Wearable Tissue Oximetry During Arm Cuff Occlusion, Walking, and Standing Tests in Outpatients With Chronic Heart Failure
This prospective, single-center, observational pilot study evaluated an investigational wearable tissue oximeter (NIRSense Argus Oximetry System, also called Envello Core) in adult outpatients with chronic heart failure in New…
- Trial name
- NCT07874386
- Testing
- Argus Oximetry System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NIRSense Inc.
Right Heart Dysfunction
Measurement of Tricuspid AnnularPlane Systolic Excursion in Transesophageal Echocardiography
The aim of this study is to measure TAPSE in TEE using two deep transgastric views. This is a prospective comparative diagnostic study where 21 CABG patients who are enrolled for the study will be studied during the…
- Trial name
- TAPSE (NCT03649854)
- Where
- Singapore
- Volunteers
- 26 people
- Sponsor
- National University Hospital, Singapore
Obesity
Evaluation of Heart Rate Variability and Endothelial Function Three Months After Bariatric Surgery
Was performed a longitudinal, study with twenty patients recruited for the bariatric surgery group and 20 for clinical treatment.
- Trial name
- NCT03911479
- Testing
- Bariatric Surgery
- Volunteers
- 40 people
- Sponsor
- Rio de Janeiro State University
Cardiac
Improve Nuclear Medicine Heart Imaging, Compare MRI Results With Single Photon Emission Computed Tomography Imaging
The purpose of this study is to compare the MRI results with the new SPECT image reconstruction method, this study will allow us to determine whether a new more accurate method of looking at the heart by nuclear study can be used…
- Trial name
- NCT00639704
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York - Upstate Medical University
Chronic Obstructive Pulmonary Disease, COPD
Effect of QVA149 (Indacaterol Maleate/Glycopyrronium Bromide) on Cardiac Function in COPD Patients
This mechanistic study is a single-center, randomized, double-blind, placebo-controlled, cross-over study to evaluate the effect of dual bronchodilation with QVA149 on cardiac and lung function parameters in hyperinflated COPD…
- Trial name
- CLAIM (NCT02442206)
- Testing
- QVA149
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
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