Clinical trials: Coronary Physiology
Heart Disease
Prediction of Bleeding and Transfusion Outcomes and Assessment of Perioperative Platelet Reactivity in Cardiac Surgery
Excessive bleeding after cardiopulmonary bypass (CPB) operations remains to be a persistent problem. Antiplatelet therapy (APT) is an integral component of perioperative management in patients undergoing cardiac surgery.
- Trial name
- NCT02277379
- Where
- Croatia
- Volunteers
- 113 people
- Sponsor
- University of Zagreb
Vulnerable Plaque
Plaque Stabilization and Restoration by Bioresorbable Vascular Scaffold
The aim of the study is to assess if implantation of a bioresorbable vascular scaffold (BVS) for intermediate coronary lesions with morphological signs of vulnerable plaque in patients prone for acute coronary syndromes (ACS)…
- Trial name
- NCT02319733
- Testing
- Bioresorbable vascular scaffold
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Canisius-Wilhelmina Hospital
Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction
Sex Related Differences in Cardiac Function
The aim of the study is to investigate sex-specific differences in LV and RV function (systolic and diastolic) with regarding the development and progression of heart failure with preserved ejection fraction based on a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05796050
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Heart Failure
Exercise Intervention on Cardiorespiratory Function in HF With DM.
Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in diabetes mellitus with heart failure.
- Trial name
- NCT04888390
- Testing
- Muti-model exercise intervention, Disease and exercise suggestion
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Cheng Kung University
Heart Disease, Coronary Artery Disease
Bleeding Prediction in Patients Following Cardiac Surgery Using Whole Blood Aggregometry and Thromboelastometry
Use of whole blood impedance aggregometry and rotational thromboelastometry can reveal useful data about platelet function and viscoelastic properties of blood clot in patients undergoing cardiac surgery.
- Conditions
- Heart Disease, Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- NCT01281397
- Where
- Croatia
- Volunteers
- 148 people
- Sponsor
- University of Zagreb
Non-Alcoholic Fatty Liver Disease
The Effect of Coenzyme Q10 on Endothelial, Vascular and Myocardial Function
Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. The aim of this study is to investigate the effects of coenzyme Q10 (CoQ10) on endothelial, vascular and myocardial function in patients…
- Trial name
- NCT05941910
- Testing
- Q10
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Attikon Hospital
ST Elevation Myocardial Infarction, Ventricular Remodeling
Impact of Ischemic Post-conditioning
Study will investigate \& compare the left ventricular remodeling \& systolic function between two groups of ST-elevation myocardial infarction undergoing primary per-cutaneous coronary intervention applying ischemic…
- Conditions
- ST Elevation Myocardial Infarction, Ventricular Remodeling, Ventricular Dysfunction, Ischemic Reperfusion Injury
- Trial name
- NCT04068116
- Testing
- Primary per-cutaneous coronary intervention
- Volunteers
- 100 people
- Sponsor
- Assiut University
Type 1 Diabetes, Hypoglycemia
Cognitive Function and Electrocardiogram (ECG) During Hypoglycemia and Blockade of the Renin-angiotensin System
Hypothesis: Treating patients with type 1 diabetes with a certain antihypertensive drug preserve cerebral function during hypoglycaemia.
- Trial name
- NCT01116180
- Testing
- Angiotensin II receptor antagonists (Candesartan)
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Louise Faerch
Cardiomyopathy
CRM and Fusion Beats: Effects of Progressive Fusion on Intra-left Ventricular Mechanical Function
This study is looking at cardiac rhythm management (CRM) and fusion beats in patients who have a pacemaker or implantable cardioverter-defibrillator (ICD), to determine if there is a correlation between the time between the…
- Trial name
- NCT00610896
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Essentia Health
Perioperative Respiratory Function, Diaphragmatic Dysfunction
LTV (Low Tidal Volüme) Ventilation and Diaphragmatic Motion in CABG (Coronary Artery Bypass Grafting)
The goal of this clinical trial is to evaluate whether low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) surgery helps preserve diaphragmatic excursion in adult patients undergoing coronary artery bypass…
- Conditions
- Perioperative Respiratory Function, Diaphragmatic Dysfunction, Low Tidal Volume Ventilation
- Trial name
- NCT07067684
- Testing
- Low Tidal Volume Ventilation During CPB
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Major Depressive Disorder
Effects of Respiratory-Gated Transcutaneous Vagal Nerve Stimulation in Major Depression (Phase 1)
This study will evaluate the short term effects of respiratory-gated transcutaneous vagus nerve stimulation on the regulation of cardiovagal activity, depressive symptomatology and immune function in subjects with major…
- Trial name
- NCT04607226
- Testing
- Active transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Disease
Cardiovascular Safety of Febuxostat and Allopurinol in Participants With Gout and Cardiovascular Comorbidities (CARES)
The purpose of this study is to see whether subjects with gout who receive febuxostat or allopurinol for up to 9 years have a higher rate of serious heart and blood vessel complications (major cardiovascular events).
- Trial name
- CARES (NCT01101035)
- Testing
- Febuxostat, Allopurinol
- Where
- 203 sites in United States, Mexico
- Volunteers
- 6,198 people
- Sponsor
- Takeda
Acute Cardiac Syndrome, Stent Thrombosis
REsponsiveness to CLOpidogrel and Stent-related Events in Acute Coronary Syndromes (RECLOSE 2 - ACS)
The main objective of the project is to assess the long-term prognostic impact of residual platelet reactivity after optimal antiplatelet therapy in a large cohort of patients with acute coronary syndrome undergoing invasive…
- Conditions
- Acute Cardiac Syndrome, Stent Thrombosis, Platelet Function, Antiplatelet Therapy
- Trial name
- RECLOSE2-ACS (NCT01231035)
- Where
- Italy
- Volunteers
- 1,789 people
- Sponsor
- Careggi Hospital
Heart Failure, Acute Decompensated Heart Failure
Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistance
Evaluation of the safety and efficacy of the ModulHeart System in patients hospitalized with acute decompensated heart failure (ADHF) and diuretic resistance
- Conditions
- Heart Failure, Acute Decompensated Heart Failure, Cardiorenal Syndrome, Heart Failure, Congestive
- Trial name
- NCT06174623
- Testing
- ModulHeart Support
- Where
- 5 sites in Australia, Georgia
- Volunteers
- 5 people
- Sponsor
- Puzzle Medical Devices Inc.
Restenosis or Adverse Cardiovascular Event
Endothelial Function and Heart Rate Variability After Stenting
The objective of this study is to evaluate whether impaired endothelial function and low heart rate variability are associated with clinical restenosis after percutaneous coronary intervention with stent implantation in patients…
- Trial name
- FUNKIS (NCT00999323)
- Testing
- stent implantation in coronary artery
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Diabetes Mellitus, Non-Insulin-Dependent, Heart Failure
Saxagliptin and Cardiac Structure and Function
Diabetes is associated with a substantially increased risk of heart failure, which is associated with substantial morbidity and mortality.
- Trial name
- SCARF (NCT02481479)
- Testing
- Saxagliptin
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Ischemic Heart Disease, Microvascular Coronary Artery Disease
Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DIAST-CMD (NCT05058833)
- Testing
- Echocardiography, Coronary flow reserve and index of microcirculatory dysfunction
- Where
- 4 sites in United States, South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Infant,Premature
Improving Right Ventricular Function in Young Adults Born Preterm
The purpose of this research is to evaluate the short-term effects of sildenafil and metoprolol on heart function in young adults born premature.
- Trial name
- NCT03696758
- Testing
- Pulmonary Function Testing, Electrocardiogram, Cardiac Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Symptomatic Congestive Heart Failure
Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods
Successful treatment of pulmonary edema was first published in 1938 by A. L. Barach. Since then, this has been the accepted method of treating acute respiratory failure due to left heart failure and edema.
- Trial name
- NCT01501734
- Testing
- watch-pat
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
CTEPH
Feasibility and Influence of Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA
Purpose of this study is to investigate whether and to what extent a cautious respiratory and movement therapy can complement medical treatment and the condition, oxygen uptake, quality of life, the pulmonary vascular pressures…
- Trial name
- NCT01393327
- Testing
- respiratory and exercise therapy
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Heidelberg University
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