Clinical trials: Coronary Physiology
Myocardial Infarction, Hypothyroidism
Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)
Based on accumulating evidences showing that hypothyroid status is associated with poor prognosis among acute myocardial infarction (AMI) patients, the study is designed to evaluate whether replacement treatment with…
- Trial name
- NCT02512978
- Testing
- Levothyroxine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimize damage to the heart muscle.
- Trial name
- NCT00965393
- Testing
- Forearm vascular study, bradykinin receptor antagonist (HOE-140)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Prevention of Thromboembolic Events, Atrial Fibrillation
A Study to Learn How the Study Treatment Asundexian Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body in Participants With Mild or Moderate Reduction of Liver Function Compared to Participants With Normal Liver Function
Researchers are looking for a better way to prevent the formation of blood clots in people who have or have had: an irregular and often rapid heartbeat a blocked blood flow to the heart a blocked or reduced blood flow to a part…
- Conditions
- Prevention of Thromboembolic Events, Atrial Fibrillation, Acute Myocardial Infarction, Non-cardioembolic Ischemic Stroke
- Trial name
- NCT05419635
- Testing
- Asundexian (BAY2433334)
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayer
Ischemic Cardiomyopathy
Intracoronary or Intravenous Infusion Human Wharton' Jelly-derived Mesenchymal Stem Cells in Patients With Ischemic Cardiomyopathy
The purpose of this study is to investigate the safety and efficacy of intracoronary or intravenous infusion human umbilical Wharton's jelly-derived Mesenchymal Stem Cell (WJMSC) in patients with ischemic cardiomyopathy secondary…
- Trial name
- WJ-ICMP Tria (NCT02368587)
- Volunteers
- 160 people
- Sponsor
- Navy General Hospital, Beijing
Infrarenal Aortic Aneurysm
Open Bifurcation Surgery Study
Different cross clamping techniques in aortic surgery causes different cardiac stress
- Trial name
- OBI (NCT01649908)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Alexander Hyhlik-Duerr, M. D.
Hypoglycemia, Type 2 Diabetes
Hypoglycemia (Low Blood Sugar) and the Heart
The risk of hypoglycemia (low blood sugar) associated with the treatment of diabetes increases with age. Hypoglycemia is a common reason for admission to hospital for older patients with diabetes.
- Trial name
- NCT01980914
- Testing
- iPro2 glucose sensor attachment
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of British Columbia
Acute and Long Term Effects of COVID-19 on Systemic Inflammation, Acute and Long Term Effects of COVID-19 on Lung Function
Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons
Background: COVID-19 virus infection differs among people. Some people have no or mild symptoms. For others, COVID-19 is life threatening and causes damage to the body s organs.
- Conditions
- Acute and Long Term Effects of COVID-19 on Systemic Inflammation, Acute and Long Term Effects of COVID-19 on Lung Function, Acute and Long Term Effects of COVID-19 on Cardiac Function, Acute and Long Term Effects of COVID-19 on Kidney Function
- Trial name
- NCT04401449
- Where
- 2 sites in United States
- Volunteers
- 202 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common complication of cardiac surgery, mainly manifested as mental confusion, anxiety, personality change and memory impairment, which seriously affects the quality of life of…
- Trial name
- NCT05586347
- Testing
- Nicardipine, normal saline
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Congenital Heart Disease, Single Ventricle
Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise Training
Introduction: The Fontan operation is the surgical treatment in most patients with either anatomic or functional single ventricles.
- Conditions
- Congenital Heart Disease, Single Ventricle, Univentricular Heart
- Trial name
- NCT02283255
- Testing
- Aerobic Exercise Training, Inspiratory Muscle Training, No Exercise Training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Coronary Heart Disease (CHD), Heart Failure
Community Exercise Treating Effect on Cardiopulmonary Disease Patients
The goal of this clinical trial is to learn if community-based exercise training can benefit patients aged 18 to 85 with diminished cardiovascular and pulmonary function.
- Conditions
- Coronary Heart Disease (CHD), Heart Failure, Cardiomyopathy, COPD
- Trial name
- NCT07154355
- Testing
- community-based exercise training
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guangdong Provincial People's Hospital
Platelet Dysfunction Due to Drugs
The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease
This study aims to assess the effects of low dose ticagrelor on platelet function testing in patients with stable coronary artery disease.
- Trial name
- TWIST (NCT04206176)
- Testing
- Ticagrelor
- Where
- Trinidad and Tobago
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Cardiovascular Disease
Monocentric Registry to Investigate the Role of Platelet Function, Platelet Genetics, Proteomics and Metabonomics in Heart Disease
Molecular targets on platelets are pivotal for the development of new pharmacological substrates for platelet inhibition and to better understand the impact of platelet-mediated inflammatory processes for the progression of heart…
- Trial name
- TuePIC (NCT01417884)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Aortic Valve Stenosis
Oxford - Fibrates in Aortic Stenosis
Aortic stenosis (AS) is characterised by left ventricular (LV) hypertrophy and altered myocardial substrate metabolism. Peroxisome proliferator-activated receptor (PPARα), a regulator of lipid metabolism is deactivated in…
- Trial name
- OxFAST (NCT05256758)
- Testing
- Fenofibrate Capsules, Placental Lactogen
- Where
- United Kingdom
- Volunteers
- 67 people
- Sponsor
- University of Oxford
Cardiovascular Diseases, Heart Diseases
Sociodemographic Regulation of Cardiovascular Function and Structure
To establish the aspects of ethnicity that are associated with the differential expression of cardiovascular disease processes in African Americans and Caucasian Americans twin children.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005476
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart
Kinesthetic Exercises on Adults
The aim of this study is to determine the possible effect of kinesthetic brain exercises on cognitive function in patients with heart failure.
- Trial name
- NCT07417748
- Testing
- Kinesthetic brain exercises, Cardiorespiratory Physiotherapy, Heart Failure drugs
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ege University
Parasympathetic Cardiovascular Function Disorder
Heart Rate Variability and Cardiorespiratory Complications During Ophthalmic Arterial Chemotherapy for Retinoblastoma
A patient undergoing ophthalmic arterial chemosurgery may experience a sudden, profound decrease in lung compliance when the microcatheter is in the ICA or ophthalmic artery.
- Trial name
- NCT03450590
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
Coronary Artery Disease, Postprandial Hyperglycemia
Vitamin D Supplementation in CAD and Postchallenge Hyperglycemia
The main aim of the investigation is to clarify, whether vitamin D supplementation in coronary artery disease patients with vitamin D deficiency and postchallenge hyperglycemia has an impact on endothelial dysfunction and…
- Conditions
- Coronary Artery Disease, Postprandial Hyperglycemia, Vitamin D Deficiency
- Trial name
- NCT01183442
- Testing
- vitamin D
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University of Graz
Coronary Disease
Real Time 3-Dimensional Stress Echocardiography
An echocardiogram is an ultrasound technique used to gather information about the heart. Standard echocardiograms create images of the heart in two dimensions, thereby named 2D (two-dimensional) echocardiography.
- Trial name
- NCT00001886
- Testing
- Real time 3-dimensional stress echocardiography
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure
Impact of Interval Training on Sympathetic Hyperactivity and Vascular Function
In this study, the investigators are testing the hypothesis that reduction in sympathetic activity would be greater following high-intensity interval training (HIIT) than moderate-intensity continuous training (MICT) and…
- Trial name
- NCT04248894
- Testing
- Exercise training of High Intensity, Exercise training of Moderate Intensity, Untraining
- Where
- 2 sites in Brazil
- Volunteers
- 35 people
- Sponsor
- University of Sao Paulo General Hospital
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