Clinical trials: Coronary Physiology
Heart Failure, Anthracycline-induced Cardiac Toxicity
Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer Patients
The goal of this randomized, double-blind, placebo-controlled clinical trial is to determine whether dapagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, can help prevent anthracycline-induced cardiotoxicity caused…
- Conditions
- Heart Failure, Anthracycline-induced Cardiac Toxicity, Endothelial Function (FMD), Arterial Stiffness
- Trial name
- Alpaca (NCT07245069)
- Testing
- Dapagliflozin 10 mg
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Phototherapy, Autonomic Nervous System
Effects of Phototherapy Associated With Sprint and Squat Training on Cardiac Autonomic Modulation
Recent studies have shown positive results in the application of phototherapy for the improvement of performance and acceleration of the healing process of the body homeostasis.
- Conditions
- Phototherapy, Autonomic Nervous System, Training
- Trial name
- NCT03566186
- Testing
- Phototherapy, Passive recovery
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Paulista University
Ejection Fraction
Effect of Gemigliptin Versus Glimepiride on Cardiac Diastolic Function in Patients With Type 2 Diabetes
Among DPP-4 inhibitors, gemigliptin is a relatively recently developed drug, and many clinical studies have shown results that are equivalent to or superior to existing DPP-4 inhibitors such as sitagliptin.
- Trial name
- NCT05663736
- Testing
- Gemigliptin, Glimepiride
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Persistent Atrial Fibrillation, Catheter Ablation
Left Atrial Function Analysis for Patients With Persistent Atrial Fibrillation Undergoing Pulmonary Vein Isolation
This prospective observational study is designed to describe the factors determining the success of pulmonary vein isolation (PVI) for patients with persistent atrial fibrillation (AF).
- Trial name
- LAMPP (NCT03242694)
- Testing
- LA pressure, voltage map, strain, scar-map, blood sampling, pulmonary vein isolation
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Heart Failure With Reduced Ejection Fraction, Left Ventricular Assist Device
Influence of Right Ventricular Function on Changes in Exercise Capacity After LVAD
This is an exploratory project with the purpose to describe the responses of the right ventricle (RV) and gas exchange during exercise in patients scheduled to undergo left ventricular assist device (LVAD) implant.
- Trial name
- NCT05916612
- Sponsor
- Henry Ford Health System
Vascular Function in Healthy Volunteers
Diesel Exhaust Inhalation, Systemic Nitric Oxide Inhibition and Cardiac Output
Exposure to combustion-derived fine particulate air pollution is associated with cardiovascular mortality and morbidity. In previous studies, exposure to diesel exhaust (a major constituent of urban particulate air pollution) has…
- Trial name
- DISCO (NCT01060930)
- Testing
- Intravenous infusion of L-NMMA and Nor-epinephrine
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure
Brain Volume and Cardiac Function in Heart Failure
Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population.
- Trial name
- NCT06623344
- Testing
- Magnetic Resonance Imaging with or without Contrast
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Coronary Artery Stent Thrombosis
Platelet Reactivity in Stent Thrombosis Patients
Recent studies have demonstrated a marked interindividual variability of clopidogrel's capacity to inhibit platelet aggregation with a substantial proportion (11-34%) of the patients considered non-responders to clopidogrel…
- Trial name
- MAPCAT (NCT01012544)
- Testing
- Clopidogrel
- Where
- Netherlands
- Volunteers
- 187 people
- Sponsor
- St. Antonius Hospital
Univentricular Heart
Impact of Exercise Training on Single Ventricle Function in Paediatric Fontan Patients
The goal of this observational study is to learn about how a prescribed Exercise Training Program would affect children living with a Fontan circulation.
- Trial name
- NCT05617534
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Children's Health Ireland
Paroxysmal Atrial Fibrillation
Atrial Electromechanical Function in Endurance Athletes With and Without Atrial Fibrillation
This study evaluates cardiac structure and function differences between healthy endurance trained athletes with atrial fibrillation and healthy age matched endurance trained athletes without atrial fibrillation.
- Trial name
- NCT03305744
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Congestive Heart Failure
Effects of Pentoxiphylline on Left Ventricular (LV) Systolic Function Indices and Circulating Biomarkers in Patients With Chronic Congestive Heart Failure (CHF)
This is a prospective, double blinded randomized clinical study to evaluate the Effects of Pentoxifylline on left ventricular systolic function indices and circulating biomarkers in patients with chronic congestive heart failure.
- Trial name
- PENT-CHF (NCT01337349)
- Testing
- Pentoxifylline
- Where
- United States
- Sponsor
- Henry Ford Health System
Cardiac Failure, Extracorporeal Membrane Oxygenation Complication
Echocardiographic Assessment of Function During ECMO Support
The purpose of this study is to evaluate echocardiographic markers of cardiac function to assess the ability of patients to successfully end VA-ECMO support.
- Trial name
- NCT01551849
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nationwide Children's Hospital
Coronary Artery Disease, Percutaneous Coronary Intervention
Physiology Optimized Versus Angio-guided PCI
Angiography-derived Fractional Flow Reserve (FFR) Virtual Percutaneous Coronary Intervention (PCI) plan is superior to conventional angiography-guided PCI in obtaining a good final physiology result, which is, in turn, associated…
- Trial name
- AQVA-II (NCT05658952)
- Testing
- Microcatheter-derived FFR, Angiography-derived FFR, Angiography-guided PCI
- Where
- 2 sites in Italy
- Volunteers
- 305 people
- Sponsor
- University Hospital of Ferrara
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 1 of 7)
NOTE: This is the first of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882516
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bern
Heart Injuries, Kidney Transplant; Complications
Perioperative Factors and Early Postoperative Kidney Graft Function Recovery
Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function…
- Trial name
- NCT06280898
- Testing
- Remote ischemic conditioning
- Where
- South Korea
- Volunteers
- 539 people
- Sponsor
- Seoul St. Mary's Hospital
Implantable Cardiac Electronic Devices, Pain
Shoulder Pain and Function in Individuals With Implantable Cardiac Electronic Devices
The primary aim of our study is to evaluate shoulder pain, range of motion, postural changes, muscle tightness, activities of daily living, upper extremity functional status, and exercise capacity in individuals with Implantable…
- Conditions
- Implantable Cardiac Electronic Devices, Pain, Upper Extremity, Posture
- Trial name
- NCT07349914
- Testing
- Not applicable- observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hacettepe University
Obesity
Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity
This study will look at how the participants daily life is affected by their heart failure. The study will also look at the change in participants body weight from the start to the end of the study.
- Trial name
- STEP-HFpEF (NCT04788511)
- Testing
- Semaglutide
- Where
- 146 sites in United States, Argentina and 11 more
- Volunteers
- 529 people
- Sponsor
- Novo Nordisk A/S
Congestive Heart Failure
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
In congestive heart failure, cardiac output is low, blood pressure is high, and the body becomes congested with fluid. In normal people, when there is high blood pressure, the heart muscle cells secrete a hormone that excretes…
- Trial name
- PPG1 (NCT00387621)
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Horng Chen
Paroxysmal Atrial Fibrillation, Pulsed Field Ablation
Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: Clinical Efficacy and Left Atrial Function Protection
This is a prospective clinical study aiming to evaluate the clinical efficacy and safety of a novel domestic pulsed field ablation (PFA) system in the treatment of paroxysmal atrial fibrillation (PAF), and to specifically assess…
- Conditions
- Paroxysmal Atrial Fibrillation, Pulsed Field Ablation, Catheter Ablation, Left Atrial Function
- Trial name
- NCT07865221
- Testing
- Novel Pulsed Field Ablation System, Radiofrequency Ablation Catheter
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Tianjin Medical University General Hospital
Coronary Artery Bypass Surgery, Cognitive Impairment
Evaluation of the Safety and Efficacy of Ang-(1-7) to Enhance Cognitive Function in Participants Undergoing CABG
Coronary Artery Bypass Graft (CABG) is a surgical procedure known to be associated with cognitive impairment. Mechanisms of cognitive impairment are complex but may include insufficient oxygenation and inflammation due to…
- Trial name
- NCT03252093
- Testing
- Angiotensin-(1-7)
- Where
- 5 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Arizona
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