Clinical trials: Coronary Stenosis
Coronary Bypass Graft Stenosis, Valvular Heart Disease
Comparison of Post-operation Cardiopulmonary Capacity of Patients Underwent Conventional and Robot-assisted Coronary Artery Bypass Graft and Valve Replacement Surgery
Robotic surgery is one of the most popular minimally invasive procedures for patients with coronary artery disease or valvular diseases.
- Trial name
- NCT05430568
- Testing
- robot-assisted surgery
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Coronary Artery Disease
Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying…
- Trial name
- NCT00921440
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Left Main Coronary Artery Disease, Stenosis
Stress Echocardiography Versus Coronary Angiography for Left Main Stenosis Detection
Left main stenosis use to be treated by bypass but with the improvement of angioplasty techniques, an increasing number of patients are submit to left main coronary angioplasty.
- Trial name
- ESTRIE-TC (NCT01620320)
- Testing
- Stress echocardiography
- Where
- Canada
- Sponsor
- Université de Sherbrooke
Hypertrophic Cardiomyopathy
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy
The overall aim of this project is to establish potential benefits of a novel lifestyle (physical activity and dietary nitrate) and pharmacological (angiotensin receptor neprilysin inhibitor) interventions in patients with…
- Trial name
- SILICOFCM (NCT03832660)
- Testing
- Lifestyle, Sacubitril/Valsartan
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 168 people
- Sponsor
- Newcastle University
DCB, De Novo Stenosis
Bail-Out Stenting and Target-vessel Failure After Drug Coated Balloon Coronary percutaneouS Angioplasty for de Novo Lesions
The goal of this observational retrospective and prospective multicentric trial is to learn about the impact of bail-out stenting (BOS) after drug coated balloon (DCB) percutaneous coronary angioplasty (PCI) in de novo coronary…
- Conditions
- DCB, De Novo Stenosis, PCI
- Trial name
- BOSS (NCT06247982)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Aortic Valve Stenosis, TAVI
Exercise Training After Transcatheter Aortic Valve Implantation
In this prospective, controlled trial, patient after TAVI will be randomized to either exercise training or usual care group.
- Conditions
- Aortic Valve Stenosis, TAVI, Transcatheter Aortic Valve Implantation, Rehabilitation
- Trial name
- FitTAVI (NCT03966417)
- Testing
- Exercise training
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Stenosis, Aortic Valve Stenosis
Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup
This study aims to evaluate the clinical value of a novel CT gantry supporting a .23 second rotation time and systematically compare it with 0.23 second rotation time, in patients with clinically indicated aortic CTA in the…
- Conditions
- Coronary Stenosis, Aortic Valve Stenosis, Cardiovascular Diseases
- Trial name
- FAST-CCT (NCT05709652)
- Testing
- Aortic CTA, .23s, Aortic CTA, .28s
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- David C. Rotzinger
Hypertrophic Cardiomyopathy
Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure
A Study on the Efficacy, Safety, and Tolerability of Perhexiline maleate in Subjects with Hypertrophic Cardiomyopathy and Moderate-To-Severe Heart Failure
- Trial name
- NCT02431221
- Testing
- Perhexiline
- Sponsor
- Heart Metabolics Limited
Aortic Stenosis, Transcatether Aortic Valve Implantation
Dapagliflozin After Transcatheter Aortic Valve Implantation
Pragmatic, controlled, prospective, randomized, open-label (open-label), evaluator-blind clinical trial (PROBE design) that will analyze the benefits of dapagliflozin treatment in patients with severe aortic stenosis discharged…
- Trial name
- DapaTAVI (NCT04696185)
- Testing
- Dapagliflozin 10 MG
- Where
- 40 sites in Spain
- Volunteers
- 1,257 people
- Sponsor
- Spanish Society of Cardiology
Atrial Fibrillation, Aortic Valve Stenosis
WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement
To evaluate the safety and effectiveness of the left atrial appendage occlusion with WATCHMAN Device in prevention of stroke and bleeding in patients with atrial fibrillation (AF) undergoing transcatheter aortic valve replacement…
- Trial name
- NCT03173534
- Testing
- WATCHMAN, TAVR
- Where
- 32 sites in United States
- Volunteers
- 350 people
- Sponsor
- samir kapadia
Coronary Artery Stenosis
Cordimax China Post Market Surveillance
Study purpose: This study is a prospective, randomized, controlled multicenter clinical research, which is to assess the effect of Cordimax and Xience V drug-eluting stents as they dealing with all kinds of complex lesions in the…
- Trial name
- NCT03185221
- Testing
- Cordimax, XIENCE V
- Where
- China
- Volunteers
- 3,660 people
- Sponsor
- Shandong Branden Med.Device Co.,Ltd
Alagille Syndrome, Pulmonary Artery Stenoses
Decreasing Hemorrhage Risk in Children With Alagille Syndrome
The goal of this interventional study is to test a hemostasis screening protocol and cardiac peri-procedural and post-operative hemostasis pathway to improving bleeding complications and improve patient survival for children with…
- Conditions
- Alagille Syndrome, Pulmonary Artery Stenoses, Acquired Von Willebrand Disease
- Trial name
- NCT05846854
- Testing
- Assessment for bleeding disorder with tailored post-operative care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Coronary Stenosis
Bifurcation Stenting Using 2 Link Stent Nobori Versus 3 Link Stent Xience
The primary objective of this study is to make a comparison of safety and efficacy of DESs with different link number (2-link Nobori and 3-link Xience) in patients with de novo true bifurcation lesions.
- Trial name
- BEGIN (NCT01574586)
- Testing
- Bifurcation stenting
- Where
- Japan
- Volunteers
- 240 people
- Sponsor
- Kurashiki Central Hospital
Mitral Valve Insufficiency, Coronary Stenosis
Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair
In the present study, the investigators aim to use the in-vivo Transcatheter Mitral Valve Repair (TMVR) model to determine how Mitral Regurgitation (MR) affects coronary hemodynamics in patients affected with severe MR and…
- Conditions
- Mitral Valve Insufficiency, Coronary Stenosis, Mitral Regurgitation, Coronary Artery Disease
- Trial name
- MitraFLOW (NCT04245956)
- Testing
- Measure of hemodynamic indices in a stenosed coronary artery using a pressure wire
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- University Hospital, Geneva
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
Symptomatic Severe Aortic Stenosis
PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - High Risk and Nested Registry 7
The purpose of this trial is to determine the safety and effectiveness of the Edwards SAPIEN 3 transcatheter heart valve and delivery systems which are intended for use in patients with symptomatic, calcific, severe aortic…
- Trial name
- PII S3HR/NR7 (NCT03222141)
- Testing
- TAVR Implantation of the THV Prosthesis
- Where
- 40 sites in United States, Canada
- Volunteers
- 583 people
- Sponsor
- Edwards Lifesciences
Stenosis, Regurgitation, Aortic
Dokimos Plus Aortic Valve Implant in 80 Patients Diagnosed With a Heart Valve Disease and Requiring Valve Replacement
This study intends to reinforce the current clinical information regarding safety and efficacy of the Dokimos Plus aortic valve prosthesis in patients in whom an aortic valve replacement with a bioprosthesis has been indicated.
- Trial name
- NCT04370041
- Testing
- Dokimos Plus aortic valve
- Where
- 3 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Swan Medical S. L.
Aortic Valve Stenosis, Aortic Valve Insufficiency
Clinical Investigation for the Foldax Tria Aortic Heart Valve- India
The purpose of this study is to conduct a clinical investigation of the Foldax Tria Aortic Valve to collect evidence on the device's safety and performance.
- Conditions
- Aortic Valve Stenosis, Aortic Valve Insufficiency, Aortic Valve Calcification, Aortic Valve Disease
- Trial name
- NCT06192706
- Testing
- Foldax Tria Aortic Valve
- Where
- 10 sites in India
- Volunteers
- 50 people
- Sponsor
- Foldax, Inc
Prader-Willi Syndrome, PWS-like Syndrome
GROWing Up With Rare GENEtic Syndromes
Introduction Rare complex syndromes Patients with complex genetic syndromes, by definition, have combined medical problems affecting multiple organ systems, and intellectual disability is often part of the syndrome.
- Conditions
- Prader-Willi Syndrome, PWS-like Syndrome, Silver Russel Syndrome, Congenital Hypopituitarism
- Trial name
- GROW UR GENES (NCT04463316)
- Testing
- Retrospective file studies
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Aortic Stenosis
Performance and Safety of the Lotus™ Valve With a FLEXible Delivery System
To confirm the acute performance and safety of the Lotus™ Valve Flex System for transcatheter aortic valve replacement (TAVR) in symptomatic patients with severe calcific aortic stenosis who are considered high risk for surgical…
- Trial name
- NCT03043404
- Testing
- Transcatheter aortic valve replacement
- Where
- 2 sites in Australia
- Volunteers
- 4 people
- Sponsor
- Boston Scientific Corporation
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