Clinical trials: Coronary Stenosis
Aortic Valve Replacement
Small Aortic Annulus - a New Solution to the Old Problem
In this prospective single-center study included 60 patients with a severe degenerative aortic stenosis and small aortic annulus (<21 mm) who underwent standard AVR with stented bioprosthesis (group 1, n=30) and aortic valve…
- Trial name
- NCT03258333
- Testing
- aortic valve replacement
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- The Federal Centre of Cardiovascular Surgery, Russia
Coronary Stenosis
Factors Related to the Progression of Non-target Coronary Lesions
The goal of this observational study is to learn about correlation between traditional risk factors and emerging risk factors on the progression of non-target coronary lesions in patients with non-target lesions on at least two…
- Trial name
- NCT06248138
- Volunteers
- 1,111 people
- Sponsor
- Mei Gao
Aortic Valve Stenosis
Parasternal vs. Sternotomy Approach for Conventional Aortic Valve Replacement
Prospective randomized study comparing aortic valve replacement using parasternal or sternotomy access with regard to quality of life and systemic inflammatory reaction.
- Trial name
- PASTA (NCT04632095)
- Testing
- Aortic valve replacement due to sternotomy, Aortic valve replacement due to parasternal right anterior mini-thoracotomy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Jena University Hospital
1- Primary (Sarcomeric) Hypertrophic Cardiomyopathy, 2- Obstructive Hypertrophic Cardiomyopathy
Neurohormonal Parameters in Hypertrophic Cardiomyopathies
The primary purpose of this study is to demonstrate that changes in plasma levels of circulating neurohormones (mainly BNP and NT-proBNP), measured at rest and post-exercise correlate with exercise functional limitation (assessed…
- Conditions
- 1- Primary (Sarcomeric) Hypertrophic Cardiomyopathy, 2- Obstructive Hypertrophic Cardiomyopathy, 3- Non Obstructive Hypertrophic Cardiomyopathy
- Trial name
- REEF-CMH (NCT01729702)
- Testing
- blood sample collection
- Where
- France
- Volunteers
- 131 people
- Sponsor
- French Cardiology Society
Aortic Valve Stenosis
Aortic Valve replAcement in eLective Patients From aOrtic Valve multiceNter Registry
Multicenter registry data analysis of aortic valve stenosis patients that underwent elective, isolated transcutaneous aortic valve implantation (TAVI) or surgical aortic valve replacement between 2015 and 2019.
- Trial name
- AVALON (NCT05308173)
- Testing
- Surgical Aortic Valve Replacement, Transcutenous Aortic Valve Implantation
- Volunteers
- 2,393 people
- Sponsor
- Nicolaus Copernicus University
Aortic Stenosis, Heart Block
Conduction Disease After Transcatheter Aortic Valve Replacement
This is a prospective single center Cardiology department observational study. The study aim is to better understand the predictors of high grade conduction abnormalities associated with TAVR such that a more robust…
- Conditions
- Aortic Stenosis, Heart Block, Aortic Insufficiency
- Trial name
- NCT04489095
- Testing
- Electrophysiology Study
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Henry Ford Health System
Hypertrophic Obstructive Cardiomyopathy
Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy
Perioperative blockage of beta-adrenoreceptors is widely used in cardiac and non-cardiac surgery to reduce the rate of cardiovascular complications.
- Trial name
- NCT05073094
- Testing
- Esmolol
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Aortic Valve Stenosis, Endovascular Aortic Valve Replacement
Heart Leaflet Technologies Valve Study
The study will be conducted in patients who are undergoing surgical aortic valve replacement on cardiopulmonary bypass. Following surgical access of the native aortic valve and prior to removal of the valve, the native valve will…
- Trial name
- HLT (NCT00710775)
- Testing
- surgical replacement of the aortic stenotic valve
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Centro Cardiologico Monzino
Coronary Artery Disease
Clinical Trial of Cilostazol Eluting Stent System (CES-1) in De Novo Coronary Artery Lesions
The purpose of the this trial is to evaluate the clinical safety and efficacy of Cilostazol eluting stent system (CES-1) for the treatment of single de novo lesions in native coronary arteries.
- Trial name
- NCT03189641
- Testing
- Cilostazol eluting stent system (CES-1)
- Where
- 6 sites in Japan
- Volunteers
- 30 people
- Sponsor
- JIMRO Co., Ltd.
Aortic Valve Stenosis
Hamburg AoRtic Valve cOhoRt
The primary aim of the study is to identify the optimal treatment modality for patients with aortic valve disease, incorporating the individual patient's risk profile and anticipated clinical outcomes.
- Trial name
- HARbOR (NCT04227002)
- Where
- Germany
- Volunteers
- 15,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Low-Flow, Low-Gradient Aortic Stenosis
Anatomic Stenosis Severity as a Prognostic Marker in Patients With Low-Flow Low-Gradient Aortic Stenosis Undergoing TAVI
The ATLAS TAVI Registry is a retrospective, investigator-initiated, multicenter registry including patients, who underwent Transcatheter Aortic Valve Implantation (TAVI) for classical or paradoxical low-flow, low-gradient aortic…
- Trial name
- ATLAS TAVI (NCT04914481)
- Where
- 11 sites in Canada, Denmark and 5 more
- Volunteers
- 1,500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Myocardial Ischaemia, Severely Calcified Coronary Stenoses
Implementation of a Standardized Algorithm for Coronary Calcification With Plaque Modification
In this study, the doctors will follow a set of rules that is called an algorithm. An algorithm is a step-by-step approach that doctors use to guide them when making decisions about the best way to treat their patients.
- Conditions
- Myocardial Ischaemia, Severely Calcified Coronary Stenoses, Coronary Calcification
- Trial name
- CYCLOPES (NCT06678594)
- Testing
- Calcium modification
- Where
- Ireland
- Volunteers
- 500 people
- Sponsor
- Royal College of Surgeons, Ireland
Coronary Artery Disease, Aortic Valve Stenosis
MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS).
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Extracorporeal Circulation; Complications
- Trial name
- MiECS (NCT05487612)
- Testing
- Minimal Invasive Extracorporeal Circulation, Conventional cardiopulmonary bypass
- Where
- 13 sites in Canada, Germany and 4 more
- Volunteers
- 1,300 people
- Sponsor
- Aristotle University Of Thessaloniki
Frail Elderly, Aortic Valve Stenosis
A STEP for Patients Prior to Undergoing TAVR: A Pilot Study
The aim of this pilot study is to establish whether a Supervised TAVR Exercise Program (STEP) can safely improve the frailty status in patients with symptomatic severe aortic valve stenosis prior to undergoing transcatheter…
- Trial name
- STEP (NCT02766075)
- Testing
- Supervised TAVR Exercise Program
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- OSF Healthcare System
Aortic Valve Stenosis, Aortic Valve Failure
Portico and Navitor India Clinical Trial
The objective of this clinical trial is to collect data on procedural safety and device performance of the Portico and Navitor devices and FlexNav delivery system to treat patients with severe aortic stenosis in the Indian…
- Conditions
- Aortic Valve Stenosis, Aortic Valve Failure, Aortic Insufficiency, Aortic Stenosis
- Trial name
- NCT05171712
- Testing
- Transcatheter Aortic Valve Replacement
- Where
- 6 sites in India
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Hypertrophy, Left Ventricular, Aortic Stenosis
Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left…
- Conditions
- Hypertrophy, Left Ventricular, Aortic Stenosis, Myocardial Ischemia, Cardiopulmonary Bypass
- Trial name
- NCT01144039
- Testing
- LG-group, HG-group
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University of Vienna
Aortic Stenosis, Inflammation
Effect of Colchicine on the Progression of Aortic Valve Stenosis - A Pilot Study
COPAS pilot is a pilot single center double blinded randomized study to determine the effect of targeted anti-inflammation therapy using colchicine, on valvular calcification activity using imaging, i.e.
- Trial name
- COPAS-Pilot (NCT05253794)
- Testing
- Colchicine 0.6 mg
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Moderate or Severe Aortic Stenosis
Sparrow App Guided Evaluation (SAGE) Vanguard Trial for Aortic Stenosis in Adults Aged Seventy and Older
The purpose of this research is to look at an approved intervention (Stethophone application) to obtain additional information about improving detection of moderate or severe aortic stenosis when compared with usual standard of…
- Trial name
- SAGE-AS (NCT07828730)
- Testing
- Stethophone
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Aortic Valve Stenosis
Balloon- Versus Self-Expanding Intraannular TAVI in Small Aortic Annuli
In Europe TAVI is now recommended for treatment of aortic valve stenosis from the age of 70 years. When performing TAVI in young patients, lifetime management becomes important in terms of anticipated TAVI-in-TAVI procedures when…
- Trial name
- BALANCE (NCT07794306)
- Testing
- Meril Octapro+ THV System, Abbott Navitor/Navitor Vision THV system
- Where
- Germany
- Volunteers
- 510 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Diabetes, Hyperlipidemia
Diabetic Under 70 (Diabetics Below 70)
A screening project of diabetics with a very high cardiovascular risk (e.g. diabetes plus coronary heart disease) who already receive cholesterol-lowering therapy.
- Conditions
- Diabetes, Hyperlipidemia, Atherosclerosis
- Trial name
- NCT00516204
- Where
- Austria
- Volunteers
- 685 people
- Sponsor
- AstraZeneca
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