Clinical trials: Coronavirus
COVID-19, SARS-CoV-2 Infection
COVID-19 on Placental Gene Expression and Pathology
Little is known regarding the effect of antenatal COVID-19 on pregnancy outcomes. The purpose of this study is to determine of COVID-19 alters histopathology and gene expression of the placenta, as evidenced by analysis at time…
- Trial name
- PROSPER (NCT04585945)
- Testing
- Positive for SARS-CoV-2 infection
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Prisma Health-Upstate
Stress, Psychological, Loneliness
Ecological Momentary Assessment and Text Message Intervention for Stress Management
Feasibility and acceptability of an Ecological Momentary Assessment (EMA) compared with an EMA plus automated text message intervention for stress management
- Conditions
- Stress, Psychological, Loneliness, Covid19, Stress
- Trial name
- NCT04907942
- Testing
- EMA + EMA and FACE Stress, EMA Alone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Click Therapeutics, Inc.
COVID, AKI
Epidemiology of Acute Kidney Injury in COVID19 Disease in United Kingdom
Severe Acute respiratory syndrome coronovirus (SARS-CoV-2) was first described in Wuhan in December 2019. It quickly spread to rest of the world and was declared pandemic by World health organisation.
- Trial name
- NCT04407156
- Testing
- acute kidney injury
- Where
- United Kingdom
- Volunteers
- 724 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
COVID-19
COVID-19 Reactogenicity
The purpose of this study is to compare post-vaccination reactions between the protein-based Novavax vaccine and the mNEXSPIKE mRNA-1283 vaccine.
- Trial name
- NCT07051031
- Testing
- Nuvaxovid (NVX-CoV2705), mNEXSPIKE mRNA-1283
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Marcel Curlin
COVID-19
CORonavirus (COVID-19) Diagnostic Lung UltraSound Study
This observational study is designed to assess whether focused lung ultrasound examination can improve the diagnosis of COVID-19 lung disease and/or make an alternative diagnosis at a patient's initial hospital presentation.
- Trial name
- COR-DLUS (NCT04351802)
- Testing
- Lung ultrasound
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University Hospital Plymouth NHS Trust
Covid19
Study in COvid-19 Patients With iveRmectin (CORVETTE-01)
Treatment of mild COVID-19 is basically performed at an outpatient clinic, then when the symptom and clinical findings exacerbate to a moderate level, patients are admitted. There is no standard treatment for mild cases.
- Trial name
- NCT04703205
- Testing
- Ivermectin 3 MG
- Where
- Japan
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Kitasato University
COVID-19
BCG Vaccination to Prevent COVID-19
The current COVID-19 epidemic threatens to overwhelm the capacity of many countries to meet their populations' health care needs.
- Trial name
- NUEVA (NCT04632537)
- Testing
- Tice® BCG (for intravesical use) BCG LIVE strain of the BCG (Merck) vaccine, Preservative-free saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
COVID-19
Relation Between Lab Finding and COVID-19 Severity
Severe acute respiratory syndrome coronavirus 2 (COVID-19) poses substantial challenges for health care systems. With a vastly expanding amount of publications on COVID-19, clinicians need evidence synthesis to produce guidance…
- Trial name
- NCT04470557
- Testing
- D-dimer,CBC.ESR,CRP,, Liver function tests ,serum ferritin and PCR for COVID-19 .
- Volunteers
- 100 people
- Sponsor
- Assiut University
COVID-19 (Coronavirus Disease 2019)
Clinical Study of Tanshinone Capsules Against COVID-19
The variation of SARS-CoV-2 has caused many countries to face the problem of multiple outbreaks. Gene mutations can change the transmicity, pathogenicity, and immunogenicity of the virus.
- Trial name
- NCT07123701
- Testing
- Tanshinone capsules
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Liu Shuwen
Coronavirus Infection
COlchicine in Moderate-severe Hospitalized Patients Before ARDS to Treat COVID-19
The most prevalent complication of COVID-19 infection is respiratory failure from severe acute respiratory syndrome (SARS), the leading cause of mortality.
- Trial name
- COMBATCOVID19 (NCT04363437)
- Testing
- Colchicine, Usual Care
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Maimonides Medical Center
COVID-19, Coronavirus
CONTAIN COVID-19: Convalescent Plasma to Limit COVID-19 Complications in Hospitalized Patients
This is a randomized, blinded phase 2 trial that will assess the efficacy and safety of anti-SARS-CoV-2 convalescent plasma in hospitalized patients with acute respiratory symptoms requiring oxygen supplementation.
- Conditions
- COVID-19, Coronavirus, Coronavirus Infection
- Trial name
- NCT04364737
- Testing
- Convalescent Plasma, Saline solution
- Where
- 9 sites in United States
- Volunteers
- 941 people
- Sponsor
- NYU Langone Health
COVID-19 Experience
Data Collection on the Model Schools Pediatric Health Initiative at 5 SBHC Sites: COVID-19 Questionnaire
The Model School Pediatric Health Initiative arose out of concern about health access inequities and disparities among some of Toronto's most vulnerable children living in our inner-city neighborhoods.
- Trial name
- SBHC (NCT04534595)
- Testing
- COVID-19
- Where
- Canada
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Covid19
Study of F-652 (IL-22:IgG2 Fusion Protein) in Patients With Moderate to Severe COVID-19
This is an interventional, multicenter, 2-arm, parallel-group, randomized, double-blind, placebo controlled, dose-escalation, safety and efficacy study of F-652 treatment versus placebo in patients aged 18 years or older with a…
- Trial name
- NCT04498377
- Testing
- F-652
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- EVIVE Biotechnology
Suicide, COVID-19
Qualitative Study of Suicidal Recrudescence Among Adolescents in November 2021
A qualitative study, combining psychiatric and anthropological perspectives, focused on the lived experiences of patients who had recourse to HPNCL emergencies during the period of November 2021, as well as the experiences and…
- Trial name
- Suicide-Covid (NCT05795894)
- Testing
- STAI-Y, BDI scale, M.I.N.I.Kid
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondation Lenval
Musculoskeletal Pain, COVID-19
Muscular and Joint Symptoms in COVID-19 Patients: Insights From Syria
Observation study, shows the relation between musckeloskeletal symptoms with during and post Covid-19 infection, by asking participants questions about there age,job,which vaccination covid participants took, residual area…
- Trial name
- NCT06328595
- Where
- Syria
- Volunteers
- 1,039 people, healthy volunteers welcome
- Sponsor
- Syrian Private University
Covid19, AKI
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection
The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients.
- Conditions
- Covid19, AKI, CKD, ESRD
- Trial name
- NCT04491227
- Where
- 12 sites in United States, Bolivia and 4 more
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Diego
COVID-19, MIS-C Associated With COVID-19
Exercise Fatigue Parameters and Endothelial Function in Pediatric Patients With a History of COVID-19 Infection or MIS-C
Acute coronavirus disease 2019 (COVID-19) infection can include cardiac and pulmonary manifestations as well as post-infectious complications such as multisystem inflammatory syndrome (MIS-C), also known as pediatric inflammatory…
- Trial name
- NCT05205642
- Testing
- Cardiopulmonary exercise test (CPET), Peripheral Arterial Tonography (PAT) using the EndoPAT™ device, Endothelin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rambam Health Care Campus
Covid19 and Pregnancy
Stress in Pregnancy During the Covid19 Pandemic and Impact on the Newborn Neurodevelopment
The Covid19 pandemic, paradoxically, represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge about the relationship between inflammation, brain development and an increased risk of…
- Trial name
- NCT06362486
- Testing
- Severity of infection, time of infection., Mental health assessment, biological
- Where
- Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Covid19, Pneumonia, Viral
Aralast NP With Antiviral Treatment and Standard of Care Versus Antiviral Treatment With Standard of Care in Hospitalized Patients With Pneumonia and COVID-19 Infection
This is a Randomized, Open-Label Study of the Efficacy and Safety of Aralast NP Infusion Therapy with Antiviral Treatment and standard of care versus Antiviral Treatment and standard of care (control group) in Hospitalized…
- Trial name
- NCT04675086
- Testing
- alpha1-proteinase inhibitor, Antiviral Agents
- Where
- United States
- Sponsor
- Blessing Corporate Services, Inc
COVID-19, SARS-CoV-2 Infection
Safety and Immunogenicity of NVX-CoV2705
This study is a Phase 3 trial designed to check the safety and immune response to a new Omicron JN.1 COVID-19 vaccine. Study researchers will give a single dose of this vaccine, called NVX-CoV2705, to approximately 120…
- Trial name
- COVID-19 (NCT07079670)
- Testing
- NVX-CoV2705
- Where
- 10 sites in United States
- Volunteers
- 676 people, healthy volunteers welcome
- Sponsor
- Sanofi