Clinical trials: Coronavirus
Acute Respiratory Distress Syndrome, COVID-19
Predictors of Severe COVID-19 Outcomes
This is a longitudinal, multi-center, observational study collecting diverse biological measurements and clinical and epidemiological data for the purpose of enabling a greater understanding of the onset of severe outcomes…
- Trial name
- PRESCO (NCT04388813)
- Where
- 8 sites in United States
- Volunteers
- 494 people
- Sponsor
- Verily Life Sciences LLC
Severe/Very Severe COVID-19 Illness
Ruxolitinib Managed Access Program (MAP) for Patients Diagnosed With Severe/Very Severe COVID-19 Illness
The purpose of this Cohort Treatment Plan is to allow access to ruxolitinib for eligible patients diagnosed with severe/very severe COVID-19 illness.
- Trial name
- NCT04337359
- Testing
- Ruxolitinib
- Sponsor
- Novartis Pharmaceuticals
COVID-19
"Artificial Intelligence-Based Data Analysis Results and Mortality Prediction in Covid-19 Patients in Intensive Care"
An artificial intelligence-based analysis will be performed using retrospective data of patients treated in adult intensive care units due to COVID-19.
- Trial name
- NCT06795880
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Kocaeli City Hospital
Covid19
Study to Investigate the Treatment Benefits of Probiotic Streptococcus Salivarius K12 for Hospitalised Patients (Non-ICU) With COVID-19
This is a randomised, open-label and controlled clinical trial aimed to investigate the adjuvant treatment benefits of probiotic Streptococcus salivarius K12 in hospitalised mild-to-moderate patients with COVID-19 disease.
- Trial name
- NCT05043376
- Testing
- Standard of care, BLIS K12
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- King Edward Medical University
COVID-19
Probe-based Confocal Laser Endomicroscopy in Critically Ill COVID-19 Patients
The study is devoted to the comparative analysis of the data received in patients with COVID-19 lung pathology using the method of probe-based confocal laser endomicroscopy of distal airways and two reference methods: high…
- Trial name
- NCT04451889
- Testing
- miniprobe Alveoflex
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Long COVID
Sauna for Long Covid
Research suggests that Whole Body Hyperthermia in a sauna-like environment can reduce symptoms related to post-acute sequelae of SARS-CoV-2 (PASC), or Long Covid.
- Trial name
- NCT05931497
- Testing
- whole body hyperthermia
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Covid19
Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients
Background: The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019.
- Trial name
- NCT04739410
- Testing
- Ivermectin
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- FMH College of Medicine and Dentistry
Covid19
Convalescent Plasma for Severe COVID-19 Patients
Plasma, the supernatant part of blood, contains a variety of different proteins, including immunoglobulins. These proteins, also called antibodies, are directed to previous foreign infecting organisms, such as virus, bacteria or…
- Trial name
- PLACOVID (NCT04547660)
- Testing
- Convalescent Plasma, Best Supportive Care
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pneumonia
A Placebo-Controlled Study of Auxora for the Extended Treatment of High- Risk Patients With Critical COVID-19 Pneumonia
Up to 240 patients with confirmed COVID-19 pneumonia with a baseline imputed PaO2/FiO2 ≤200 receiving oxygen therapy via a high flow nasal cannula (HFNC) or non-invasive ventilation (NIV) will be enrolled at up to 40 sites.
- Trial name
- CARDEA-Plus (NCT05171920)
- Testing
- Auxora
- Where
- 3 sites in United States
- Sponsor
- CalciMedica, Inc.
Hypertension, Hypoxia
The VISION-Acute Study
AIM: We propose an innovative approach using Lifelight® smart technology that will enable the continued provision of high level patient care at the same time as reducing pressure on nursing and equipment resources.
- Conditions
- Hypertension, Hypoxia, Hypotension
- Trial name
- NCT04589923
- Testing
- Lifelight® Data Collect Blood Pressure Group, Lifelight® Data Collect Oxygen Saturation Group
- Where
- United Kingdom
- Volunteers
- 127 people
- Sponsor
- Xim Limited
Corona Virus Infection, Flu Vaccine
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
The purpose of this study is to measure immunity to the flu vaccine over time in patients who have had COVID-19 and may have other medical conditions including obesity, type 2 diabetes, chronic fatigue, or long-term COVID-19…
- Conditions
- Corona Virus Infection, Flu Vaccine, Immunity
- Trial name
- NCT04579588
- Testing
- Flu shot
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Stanford University
SARS-CoV-2 Infection
Halodine Nasal Antiseptic in Patients With COVID-19
Povidone iodine (PVP-I) is a well-known broad spectrum, resistance free antimicrobial agent that has a long history of safe and effective use.
- Trial name
- NCT04517188
- Testing
- Povidone-Iodine Solution 1.25% w/w [0.125% available iodine] USP
- Volunteers
- 40 people
- Sponsor
- Halodine LLC
Covid19
Impact of Steroids on Inflammatory Response in Covid-19
we designed this study to observe the efficacy and safety of dexamethasone versus methylprednisolone in covid-19 diseased patients upon monitoring the inflammatory response and to compare the outcome when these steroids will be…
- Trial name
- NCT04909918
- Testing
- Dexamethasone, Methylprednisolone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Long COVID, Multiple Chronic Conditions
The Impact of Long COVID on People Living With Pre-existing LTC
The goal of this observational study is to learn about the impact of long COVID on people who have multiple (two or more) pre-existing long-term conditions (such as diabetes and asthma).
- Trial name
- NCT06223997
- Volunteers
- 20 people
- Sponsor
- University of Leicester
Covid19
FEnofibRate as a Metabolic INtervention for COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoC-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with a high incidence of acute respiratory distress syndrome (ARDS) and death.
- Trial name
- FERMIN (NCT04517396)
- Testing
- Fenofibrate/fenofibric acid, Usual care
- Where
- United States
- Volunteers
- 701 people
- Sponsor
- University of Pennsylvania
Long COVID
PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID
Some people who had COVID-19 continue to have symptoms for weeks, months, or even years after their infection. This is often called "Long COVID" or Post-Acute Sequelae of SARS-CoV-2 (PASC).
- Trial name
- NCT07661862
- Testing
- PERCEIVE-Outreach Disease Management Program
- Where
- 2 sites in Australia
- Volunteers
- 577 people
- Sponsor
- University of Tasmania
2019 Novel Coronavirus Disease, 2019 Novel Coronavirus Infection
Evaluation of the AudibleHealth Dx AI/ML-Based Dx SaMD Using FCV-SDS in the Diagnosis of COVID-19 Illness: Clinical Validation
The AudibleHealth Dx is a diagnostic software as a medical device (Dx SaMD) consisting of an ensemble of software subroutines that interacts with a proprietary database of Signal Data Signatures (SDS), using Artificial…
- Conditions
- 2019 Novel Coronavirus Disease, 2019 Novel Coronavirus Infection, 2019-nCoV Disease, COVID-19 Pandemic
- Trial name
- NCT05364268
- Testing
- Diagnostic Test: Diagnostic Software as Medical Device
- Where
- United States
- Volunteers
- 514 people, healthy volunteers welcome
- Sponsor
- AudibleHealth AI, Inc.
Covid-19
Famotidine vs Placebo for the Treatment of Non-Hospitalized Adults With COVID-19
The overall objective of this study is to evaluate the clinical efficacy of oral famotidine in symptomatic non-hospitalized patients with confirmed COVID-19.
- Trial name
- NCT04724720
- Testing
- Famotidine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Northwell Health
Viral Pneumonia
Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection
The goal of this Phase 2 study is to assess the safety, antiviral biomarker responses and efficacy of SNG001 when given to patients requiring invasive mechanical ventilation due to a respiratory virus infection.
- Trial name
- INVENT (NCT06999603)
- Testing
- SNG001
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Synairgen Research Ltd.
Covid19
Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients
As no curative treatment for SARS-CoV-2 is currently available, most public health measures to contain the pandemic are based on preventing the spread of the pathogen.
- Trial name
- BUCOSARS (NCT04707742)
- Testing
- Betadine© bucal 100 mg/ml, Oximen® 3%, Clorhexidine Dental PHB©
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana