Clinical trials: Coronavirus Disease 2019
Covid19
Evaluation of Ivermectin Mucoadhesive Nanosuspension as Nasal Spray in Management of Early Covid-19
Ivermectin showed a strong viricidal effect upon covid19 virus in vitro as proved by many authors according to many studies , covid virus stay in postnasal space for 4 days before starting general manifestation, so ivermectin…
- Trial name
- NCT04716569
- Testing
- intranasal ivermectin spray
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- South Valley University
COVID-19, Asymptomatic Pregnant
COVID-19 PCR Test Results in Asymptomatic Pregnants
In order to prevent contamination from the pregnant women hospitalized in this clinic, the RT-PCR test is performed from the oropharyngeal and nasal swab sample taken before hospitalization.
- Trial name
- NCT04410939
- Testing
- Reverse transcription polymerase chain reaction
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
COVID-19
Mechanisms Underlying Cardiovascular Consequences Associated With COVID-19 and Long COVID
AIM 1. Characterize cardiovascular phenotypes of long COVID by cardiopulmonary, meta-bolic, and cardiac mechanical/physiological responses to exercise and microvascular vasomotor function. AIM 2.
- Trial name
- NCT06427512
- Where
- United States
- Sponsor
- Columbia University
Burnout, Professional, Depression
Burnout and Medical Errors in the Anaesthesiology Fraternity During Covid-19 Pandemic
We plan to perform an observational study to evaluate the prevalence of burnout, depression and medical errors in a designated exclusive Covid-19 patients hospital in Malaysia, during the Covid-19 pandemic.
- Conditions
- Burnout, Professional, Depression, Medical Errors, Covid-19
- Trial name
- NCT04362319
- Testing
- Questionnaire forms
- Where
- Malaysia
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Malaya
COVID-19 Infection
Immunosupressive Treatment in COVID-19 Patients
SAM-COVID is a retrospective cohort study that aims to determine the impact of immunosuppressive drugs and immunoglubulins in the outcome of patients with COVID-19.
- Trial name
- SAM-COVID (NCT04382781)
- Testing
- NO-Immunosuppressive, Immunosuppressive, Immunoglubulins
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
COVID-19
POC Study to Evaluate the Performance of the AcuVid COVID-19 Rapid Antigen Saliva Test
The AcuVid COVID-19 Rapid Antigen Saliva Test is a lateral flow immunoassay to detect SARS-CoV-2 nucleocapsid antigens in human saliva specimens from individuals suspected of COVID-19 by their healthcare provider within the first…
- Trial name
- NCT05119530
- Testing
- AcuVid COVID-19 Rapid Antigen Saliva Test
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Therma Bright Inc
Covid19, COVID-19 Pneumonia
Efficacy and Safety of Antimicrobial Stewardship Intervention in Hospitalized COVID-19 Patients (COVASP)
COVID-19 is respiratory disease caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), a novel coronavirus which has spread rapidly across the world with over 149.9 million laboratory confirmed cases and over 3.1…
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Lower Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- COVASP (NCT04896866)
- Testing
- Antimicrobial stewardship prospective audit and feedback
- Where
- 3 sites in Canada
- Volunteers
- 833 people
- Sponsor
- University of Alberta
Covid19
Aggrenox To Treat Acute Covid-19
The purpose of this study is to explore the efficacy of Aggrenox in patients with SARS-CoV-2 infection with symptoms consistent with COVID-19.
- Trial name
- ATTAC-19 (NCT04410328)
- Testing
- Dipyridamole ER 200mg/ Aspirin 25mg orally/enterally AND Standard of care, Standard of care
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Rutgers, The State University of New Jersey
Post-COVID-19 Syndrome
The Effect of Amantadine on Post-COVD-19 Fatigue
This study aimed to investigate amantadine's safety and its effect on reducing post-COVID-19 fatigue.
- Trial name
- NCT05667077
- Testing
- Amantadine
- Where
- Iran
- Volunteers
- 83 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
COVID-19 Pandemics, Obstetrics and Gynecology
National Survey of the Impact of COVID-19 Pandemics
COVID-19 pandemics have changed extensively the lives around the world. Although most physicians of obstetrics and gynecology have no critical role in the frontline against COVID-19 pandemics, their work, research and education…
- Conditions
- COVID-19 Pandemics, Obstetrics and Gynecology, Workload, Questionnaire
- Trial name
- CMDA-SURVEY2 (NCT04491201)
- Testing
- Customized questionnaire
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Lei Li
COVID19, Hematologic Malignancy
Study Evaluating the Efficacy of Hydroxychloroquine and Azithromycine in Patients With COVID-19 and Hematological Malignancies (HYACINTHE)
The primary objective of this phase 2, multicentric, placebo-controlled double-blind, randomized study is to evaluate the efficacy of the combination of hydroxychloroquine and azithromycine on the viral load drop at day 5 among…
- Trial name
- HYACINTHE (NCT04392128)
- Testing
- Hydroxychloroquine Sulfate 200 MG [Plaquenil], Azithromycin 250 MG Oral Capsule
- Where
- France
- Sponsor
- Institut de cancérologie Strasbourg Europe
Acute Respiratory Distress Syndrome
Ventilation-Perfusion Matching in Early-stage Prone Position Ventilation
Prone positioning has been widely used in critical care medicine to improve oxygenation in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NCT05816928
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Peking Union Medical College Hospital
COVID-19, Hematopoietic Stem Cell Transplantation
A Study to Evaluate the Safety and Efficacy of COVID-19 Convalescent Plasma (CCP) Transfusion to Prevent COVID-19 in Adult Recipients Following Hematopoietic Stem Cell Transplantation
The study is to evaluate the safety and efficacy of COVID-19 convalescent plasma (CCP) transfusion to prevent COVID-19 in adult recipients following hematopoietic stem cell transplantation.
- Trial name
- NCT05904067
- Testing
- COVID Convalescent Plasma
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Critical Illness
Reducing Post-traumatic Stress Disorder After ICU Discharge With the IPREA3 Program
Reducing discomfort in the intensive care unit (ICU) should be beneficial to longterm outcomes. This study assesses whether a tailored multicomponent program for discomfort reduction may be effective in reducing post-traumatic…
- Trial name
- PTSD-REA (NCT03991611)
- Testing
- Administration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts
- Where
- 33 sites in France
- Volunteers
- 3,312 people
- Sponsor
- Centre Hospitalier of Chartres
Occupational Stress
Psychological Impact of COVID19 Among Doctors in Assiut University Hospitals
study aimed to investigate the psychological impact of corona virus among doctor in Assiut University Hospitals, mainly stress and burn out will be assessed
- Trial name
- NCT04363229
- Testing
- maslach burnout inventory questionnair
- Volunteers
- 250 people
- Sponsor
- Assiut University
COVID19, Corona Virus Infection
Study of Biomarkers in the Long-term Impact of Coronavirus Infection in the Cardiorespiratory System
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a significant threat to global health.
- Conditions
- COVID19, Corona Virus Infection, Myocardial Injury, Pneumonia
- Trial name
- PostCOVID19 (NCT04353245)
- Testing
- BIOMARKERS IN THE LONG TERM IMPACT OF CORONAVIRUS INFECTION IN THE CARDIORRESPIRATORY SYSTEM
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- University of Sao Paulo General Hospital
Infectious Disease, COVID-19
Safety and Immunogenicity of RVM-V001 in Healthy Individuals Previously Vaccinated With BNT162b2 and mRNA-1273
Phase 1, open-label, dose-escalation study to evaluate the safety, tolerability, and immunogenicity of RVM-V001 administered as a single intramuscular injection in healthy adults.
- Trial name
- NCT05420077
- Testing
- RVM-V001 10 µg, RVM-V001 30 µg, RVM-V001 60 µg
- Where
- 2 sites in Australia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- RVAC Medicines (US), Inc.
Infections, Respiratory, Fever
Impact of Swab Site and Sample Collector on Testing Sensitivity for COVID-19 Virus in Symptomatic Individuals
Operational project to compare clinician collected nasopharyngeal (NP) samples to patient-obtained tongue, nasal and mid-turbinate (MT) samples in the detection of SARS-CoV-2 in an outpatient clinic setting
- Conditions
- Infections, Respiratory, Fever, Cough
- Trial name
- NCT04321369
- Testing
- Testing Sensitivity for SARS-CoV-2 Virus in Symptomatic Individuals
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- UnitedHealth Group
COVID-19
Immunogenicity and Safety of COVID-19 Vaccine in Population Aged 18 Years and Above
This is a randomized, blinded, positive-controlled study to evaluate the immunogenicity and safety of Recombinant SARS-CoV-2 Vaccine (CHO Cell) LYB001, in population aged 18 years old and above（negative antibody against…
- Trial name
- NCT05663086
- Testing
- One dose group, Two doses group, Aged 18-59 years
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Guangzhou Patronus Biotech Co., Ltd.
Covid19, Cognitive Impairment
The COGCOV Study in ICU Patients
Acute Respiratory Distress syndrome (ARDS) is a pulmonary systematic inflammatory response, leading to acute respiratory failure with hypoxia and/or hypercarbia.
- Trial name
- COGCOV (NCT04593069)
- Testing
- Neurocognitive assessment
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Ziekenhuis Oost-Limburg
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