Clinical trials: Coronavirus Disease-2019
COVID-19 Pneumonia
Leronlimab in Moderately Ill Patients With COVID-19 Pneumonia
Leronlimab (PRO 140) is a humanized IgG4,k monoclonal antibody (mAb) that recognizes the C-C chemokine receptor type 5 (CCR5). Disruption of the C-C chemokine ligand 5 (CCL5)-CCR5 axis via leronlimab-mediated CCR5 blockade might…
- Trial name
- NCT04901676
- Testing
- Leronlimab
- Where
- 27 sites in Brazil
- Volunteers
- 612 people
- Sponsor
- Hospital Israelita Albert Einstein
Coronavirus, Iatrogenic Disease
Adverse Events Related to Treatments Used Against Coronavirus Disease 2019
The outbreak of Covid-19 started several clinical trials and treatment experiments all over the world in the first months of 2020.
- Conditions
- Coronavirus, Iatrogenic Disease, Acute Kidney Injury, ARDS, Human
- Trial name
- CovidTox (NCT04314817)
- Testing
- Any drug used to treat Covid-19
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Characteristics Diseases, Outcome, Fatal
Characteristics and Outcome of Coronavirus Disease 2019 (COVID-19) in Egypt
The World Health Organization (WHO) has recently declared coronavirus disease 2019 (Covid-19) a public health emergency of international concern. Egypt is one of the countries that has been infected by Covid-19.
- Trial name
- COVID-19 (NCT04339322)
- Testing
- Follow up
- Volunteers
- 200 people
- Sponsor
- Assiut University
COVID-19 Disease, Thromboembolism, Venous
Increased Risk of VTE and Higher Hypercoagulability in Patients Recovered in ICU and in Medical Ward for COVID-19
The aim of this study is to verify if patients admitted to hospital in a medical division and in the intensive care unit for a COVID-19 infection are at higher risk of developing a VTE complication and if they actually present an…
- Trial name
- VTE-COVID (NCT04359212)
- Testing
- thromboprophylaxis with low-molecular-weight heparin or fondaparinux
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Quovadis Associazione
Coronavirus Disease 2019 (Covid19), Hematopoietic Neoplasms
Impact of the Immune System on Response to Anti-Coronavirus Disease 19 (COVID-19) Vaccine in Allogeneic Stem Cell Recipients (Covid Vaccin Allo)
The present study is a prospective phase IV study. All participants will receive the anti-Coronavirus Disease 2019 (COVID-19) Vaccine (messenger Ribonucleic acid-based vaccine, BNT162b2 or Comirnaty®, commercialized by…
- Trial name
- NCT04951323
- Testing
- anti-COVID19 mRNA-based vaccine (BNT162b2, Comirnaty®, commercialized by Pfizer)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Liege
COVID-19
Coronavirus Disease 2019 (COVID-19) During Pregnancy: Prevalence of Seroconversion, Effect on Maternal and Perinatal Outcomes and Risk of Vertical Transmission (COVID-MAP)
The objectives of this proposal are to: 1) determine the rate of SARS-CoV-2 seroconversion in unselected pregnant women in Hong Kong; 2) determine the rate of SARS-CoV-2 infection in women presenting with miscarriage and…
- Trial name
- NCT04465474
- Testing
- Non Intervention
- Where
- 10 sites in China, Hong Kong and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Coronavirus Disease 2019 Vaccines, Renal Dialysis
Safety and Efficacy of the Coronavirus Disease 2019 Vaccine in Hemodialysis Patients
It is unknown whether Coronavirus disease 2019 vaccines confer the same high level of protection in patients with kidney disease as reported for participants in recent trials, who were generally healthy.
- Trial name
- NCT04944433
- Where
- Argentina
- Volunteers
- 950 people
- Sponsor
- Hospital Italiano de Buenos Aires
Covid19
ANTIBODY BASED TESTS FOR SARSCoV-2 COVID-19) - Evaluation of Patients and Healthcare Providers in the Confines of Healthcare Settings
This study will be conducted as a registry to identify asymptomatic or symptomatic persons to determine whether they carry SARS-CoV-2 antibodies.
- Trial name
- NCT04352764
- Testing
- CoronaCideTM COVID-19 IgM/IgG Rapid Test and Premier Biotech COVID-19 IgM/IgG Rapid Test
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Hypothyroidism, Thyroid Diseases
Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism
Hypothyroidism is a common clinical entity which is often complicated by dyslipidemia. It is also reported increased risk for incidence of atherosclerosis and resulting coronary heart disease(CHD), heart failure(HF) and…
- Conditions
- Hypothyroidism, Thyroid Diseases, Endocrine System Diseases
- Trial name
- NCT01848171
- Testing
- L-thyroxine
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Shandong Provincial Hospital
Coronavirus Disease (COVID-19)
Study of MK-4482 for Prevention of Coronavirus Disease 2019 (COVID-19) in Adults (MK-4482-013)
The purpose of the study is to assess if the study medication (molnupiravir, MK-4482) will prevent symptomatic coronavirus disease 2019 (COVID-19) in adults who live with someone with confirmed COVID-19 infection.
- Trial name
- MOVe-AHEAD (NCT04939428)
- Testing
- Molnupiravir
- Where
- 226 sites in United States, Argentina and 21 more
- Volunteers
- 2,441 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Covid19
COVID-19 Soliris Expanded Access Protocol
This protocol provides participants with COVID-19 access to Soliris.
- Trial name
- NCT04802083
- Testing
- Eculizumab
- Sponsor
- Alexion Pharmaceuticals, Inc.
Covid-19
Treatment of Severe Coronavirus Disease 2019 (COVID-19) With Convalescent Plasma
The investigators hypothesize that use of convalescent plasma donated from individuals recovered from Coronavirus Disease 2019 (COVID-19) will help expedite recovery of individuals with active, severe COVID-19 infection.
- Trial name
- Inova-CCP (NCT04502472)
- Testing
- Convalescent plasma transfusion
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Inova Health Care Services
Covid19, Liver Transplant
Liver Transplantation and Coronavirus Disease 2019 (COVID-19)
The COVID-19 pandemic together with the strategies that are applied to control it are generating high morbidity and mortality worldwide.
- Trial name
- NCT04695756
- Testing
- COVID-19 pandemic
- Where
- Argentina
- Volunteers
- 1,000 people
- Sponsor
- Hospital Italiano de Buenos Aires
COVID-19 Pandemic
Diagnostic Accuracy of Self-sampling Versus Healthcare Sampling for Coronavirus-Disease-2019 Detection.
The current Coronavirus Disease 2019 (COVID-19) pandemic continues to be a worldwide health emergency. To contain the spread of disease, high demands on testing availability and capacity are observed.
- Trial name
- COVID-19 (NCT05209178)
- Testing
- Collection of nasal and oropharyngeal specimen for COVID19 antigen test
- Where
- Denmark
- Volunteers
- 3,070 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy Participants
Drug-Drug Interaction Study to Estimate the Effect of PF-07321332/Ritonavir and Ritonavir on Midazolam in Healthy Participants
The purpose of this study is to estimate the effect PF-07321332/Ritonavir and Ritonavir on Midazolam (a cytochrome P450 [CYP]3A4 substrate) in Healthy Adult Participants.
- Trial name
- NCT05032950
- Testing
- Midazolam, PF-07321332/ritonavir + Midazolam, Ritonavir + Midazolam
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
COVID-19
Favipiravir Combined With Tocilizumab in the Treatment of Corona Virus Disease 2019
The purpose of this study is to evaluate the efficacy and safety of favipiravir combined with tocilizumab in the treatment of corona virus disease 2019.
- Trial name
- NCT04310228
- Testing
- Favipiravir Combined With Tocilizumab, Favipiravir, Tocilizumab
- Where
- 6 sites in China
- Volunteers
- 150 people
- Sponsor
- Peking University First Hospital
Prone Position, Coronavirus Disease 2019
Awake Prone Positioning for Non-intubated COVID-19 Patients
The burden of coronavirus disease 2019 (COVID-19) pandemic is still on a rising course making a great stress on medical resources throughout the world.
- Conditions
- Prone Position, Coronavirus Disease 2019, Oxygenation
- Trial name
- NCT04760561
- Testing
- prone position group
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Damanhour University
Coronavirus Disease 2019
Clinical Trials of the Consistency and Non-inferiority Bridging Between Batches of Recombinant New Coronavirus Vaccine (CHO Cells)
Popular topic:Clinical trials of the consistency and non-inferiority bridging between batches of recombinant new coronavirus vaccine (CHO cells) Research purpose:Main purpose:1)To evaluate the interbatch consistency of…
- Trial name
- NCT05091411
- Testing
- Recombinant new coronavirus vaccine (CHO cell) group
- Where
- China
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
COVID-19, COVID-19 (SARS-CoV-2 Infection)
Evaluation of Safety, Tolerance, and Efficacy of Allogeneic LB-DTK-COV19 in Severe Coronavirus Disease 2019 Patients
The goal of this clinical trial is to evaluate the safety, tolerability, and efficacy of allogeneic SARS-CoV-2-Specific T cells (LB-DTK-COV19) in patients with persistent clinical symptoms following a positive SARS-CoV-2 PCR test…
- Trial name
- NCT07709637
- Testing
- LB-DTK-COV19
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- LucasBio
Covid19, Corona Virus Infection
Effect of Pentoxifylline on Prognosis of Coronavirus Disease 2019 (COVID- 19) Infection
Coronavirus disease 2019 (COVID-19) remains a threatening pandemic, due to its rapid transmission, uncertain risk factors for progression that lead to its lethality and yet unsatisfactory antiviral therapy or prophylaxis.
- Conditions
- Covid19, Corona Virus Infection, Cytokine Storm
- Trial name
- NCT04739345
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Ain Shams University