Clinical trials: Correction of Nasolabial Folds
Correction of Nasolabial Folds
A Clinical Investigation of the Decoria® Aesthetic Group (DAG) for Correction of Nasolabial Folds (NLF)
Decoria intense is a class III medical device and is CE-marked and has been on the market since 2014. Decoria intense is a hyaluronic acid filler that will be used according to intended use for correction of nasolabial folds.
- Trial name
- Decorate01 (NCT05235126)
- Testing
- Decoria intense
- Where
- 2 sites in Sweden
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Bohus Biotech AB
Correction of Nasolabial Folds
Post Market Study Evaluating Princess Filler Lidocaine for the Correction of Nasolabial Folds
In this study, eligible subjects with moderate to severe nasolabial folds will be treated with Princess® FILLER Lidocaine and will return for follow-up assessments 2, 4, 24 and 36 weeks after the treatment.
- Trial name
- FINO (NCT03611491)
- Testing
- Princess FILLER Lidocaine
- Where
- 2 sites in Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Croma-Pharma GmbH
Lips Enhancement Nasolabial Fold Correction Midface Volume Deficit
THE EVALUATION OF THE SAFETY AND PERFORMANCE OF AN INJECTABLE HYALURONIC ACID FILLER
Evaluation of the safety and performance of the investigational device in its three concentrations for cheek and lips augmentation and correction of the nasolabial folds, assuming that the performance of the product will be…
- Trial name
- NCT07763990
- Testing
- HLR-1, HLR-2, HLR-3
- Where
- 2 sites in Israel
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Hallura Ltd.
Correction of Nasolabial Folds
Clinical Study to Evaluate the Efficacy and Safety of Dermalax Implant Plus
This study is to verify that Dermalax Implant Plus is not inferior to the reference device, Restylane® Sub-Q, in terms of efficacy and safety in the correction of nasolabial folds
- Trial name
- NCT02179606
- Testing
- Dermalax Implant Plus, Restylane Sub-Q
- Where
- 2 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Across Co., Ltd.
Moderate to Severe Nasolabial Folds
Saypha® Volume LIdocaine in Nasolabial Folds
Comparison of saypha Volume Lidocaine from 2 different manufacturing locations in correcting moderate to sever nasolabial folds
- Trial name
- SAVINO (NCT04883632)
- Testing
- Saypha Volume Lidocaine
- Where
- 3 sites in Austria
- Volunteers
- 110 people
- Sponsor
- Croma-Pharma GmbH
Nasolabial Fold
Clinical Trial to Evaluate the Efficacy and Safety in Nasolabial Fold After Rhytidectomy Using Non-absorbable Mesh
The aim of this study is to evaluate the efficacy and safety of the investigational device, RPM,non-absorbable polypropylene mesh made by D Med, in correction of Nasolabial fold.
- Trial name
- NCT01775293
- Testing
- Non-absorbable polypropylene mesh
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Facial Wrinkles
Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft
This study is to determine the safety and effectiveness of Belotero® Soft compared to active comparator in the correction of mild facial wrinkles, such as nasolabial folds.
- Trial name
- NCT00877279
- Testing
- CosmoDerm1, Belotero Soft
- Where
- 5 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Nasolabial Folds, Wrinkles
Non-comparative Evaluation of Facial Expressions Following Lower Face Correction Using Emervel Classic and Emervel Deep
Study is designed to characterize subject and treating investigator reported outcomes in the early post-treatment period, following bilateral correction of nasolabial folds using Emervel Classic and Emervel Deep. 1.
- Trial name
- NCT02672644
- Testing
- Emervel Classic, Emervel Deep
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Nasolabial Folds, Wrinkles
TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines, and Juvéderm® Ultra XC for the Correction of Nasolabial Folds
The purpose of this study is 1) to compare the effectiveness and safety of TEOSYAL® RHA Global Action versus Juvéderm® Ultra XC, and 2) to compare the effectiveness and safety of TEOSYAL® RHA Deep Lines versus Juvéderm® Ultra XC…
- Trial name
- NCT02195427
- Testing
- TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines
- Where
- 5 sites in United States
- Volunteers
- 148 people
- Sponsor
- Teoxane SA
Nasolabial Fold Correction
Multicenter Study to Evaluate the Safety and Efficacy of Revanesse® Ultra Retreatment
To compare improvement with retreatment for all subjects undergoing correction of nasolabial folds (NLFs) in the initial SYM2014-02 study, who were retreated with Revanesse Ultra at Visit 6/Week 24 and to determine the safety of…
- Trial name
- Retreatment (NCT02984878)
- Testing
- Revanesse Ultra
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Prollenium Medical Technologies Inc.
Correction of Nasolabial Folds
Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers
The purpose of this study is to characterize the safety and performance in normal therapeutic use of the Artiste System in comparison to standard manual administration of dermal fillers.
- Trial name
- NCT01492140
- Testing
- Subdermal Injection, Artiste Assisted Injection System
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TKL Research, Inc.
Facial Wrinkles at the Nasolabial Folds
A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)
The purpose of this research study is to evaluate the safety and effectiveness of injection with DGE Injectable Gel (hyaluronic acid with lidocaine manufactured by Genzyme Biosurgery) as compared to injection with Restylane (a…
- Trial name
- NCT00444626
- Testing
- Dermal Gel Extra (DGE), Restylane, EMLA Cream
- Where
- 6 sites in United States
- Volunteers
- 140 people
- Sponsor
- Genzyme, a Sanofi Company
Wrinkle Reduction
Filler Post Market Survey (FIPS)
This Post-Market Clinical Follow-Up (PMCF) survey aims to descriptively evaluate the clinical performance and safety of saypha® filler when used under routine clinical practice for the correction of moderate to severe nasolabial…
- Trial name
- FIPS (NCT07475455)
- Testing
- Hyaluronic acid dermal filler (routine clinical use)
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Croma-Pharma GmbH
Moderate to Severe Nasolabial Folds
Post-Market Study of JUVÉDERM VOLIFT™ With Lidocaine for the Correction of Nasolabial Folds
A prospective, open-label, multi-center, observational, post-market study evaluating JUVÉDERM VOLIFT™ for the correction of moderate to severe nasolabial folds
- Trial name
- NCT01680497
- Testing
- Crosslinked hyaluronic acid dermal filler
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Allergan
Nasolabial Folds
Safety and Effectiveness of Sculptra Aesthetic for Correction of Nasolabial Folds.
This study has been designed to evaluate the safety of Sculptra Aesthetic as a single regimen for correction of Nasolabial Fold (NLF) contour deficiencies after changes in reconstitution and injection procedures compared to the…
- Trial name
- NCT03780244
- Testing
- Sculptra Aesthetic 8ml, Sculptra Aesthetic 5ml
- Where
- 5 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Skin Aging, Facial Wrinkles
Study of the Subdermal Implant "Ultracol"
Study of the effectiveness of the medical device "Intradermal implant, sterile ULTRACOL based on polydioxanone (ULTRA V Co., Ltd., Korea) in the correction of skin contour defects.
- Conditions
- Skin Aging, Facial Wrinkles, Senile Skin Atrophy, Lipodystrophy
- Trial name
- NCT07617350
- Testing
- Administration of the prepared solution - 1 time Post injection observation - 30, 60, 160 days from the date of the first injection.
- Where
- Russia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Estelab Clinic
Nasolabial Folds, Wrinkles
Real-Life Evaluation of the HA Dermal Filler ESTYME® LIFT
The objective of this post-market interventional study is to confirm, under real-life conditions, the safety and performance of a hyaluronic acid-based dermal filler intended for the aesthetic correction of nasolabial folds.
- Trial name
- NCT07385053
- Testing
- Injection of the Hyaluronic Acid-Based Dermal Filler ESTYME® LIFT (Now Marketed as ESTYME® FORM).
- Where
- 3 sites in France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Symatese
Nasolabial Folds Correction
Evaluation of the Filler Performance on the Nasolabial Folds of Aliaxin® EV With and Without Lidocaine 0.3%
Evaluation of the filler performance on the nasolabial folds of Aliaxin® EV with and without lidocaine 0.3%: comparison within subjects (half face method)
- Trial name
- NCT03273556
- Testing
- Aliaxin® EV Essential Volume (IBSA Farmaceutici Italia S.r.l.) with Lidocaine 0.3%, Aliaxin® EV Essential Volume (IBSA Farmaceutici Italia S.r.l.)
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Nasolabial FOLD
To Evaluate the Efficacy and Safety of Injection With HARA as Compared to Restylane® Lidocaine in Temporary Correction of Nasolabial Folds
Investigational Device : HARA (Hyaluronic Acid Filler) Title : A Single center, Randomized, Subject \& Evaluator-blind, Matched pairs, Active-controlled design Pivotal study to Evaluate the Efficacy and Safety of Injection with…
- Trial name
- NCT04224649
- Testing
- HARA Filler(Hyaluronic acid Filler), Restylane® Lidocaine
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Nasolabial Folds in Chinese Population
Restylane Defyne Compared to Restylane for Correction of Moderate to Severe Nasolabial Folds
This is a randomized, split face, multicenter study to evaluate the efficacy and safety of Restylane Defyne compared to Restylane in correction of NLFs.
- Trial name
- NCT03003130
- Testing
- Restylane Defyne, Restylane
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Galderma R&D