Clinical trials: Cortical Plasticity
Stroke, Ischemic
Motor Recovery Through Plasticity-Inducing Cortical Stimulation
Using the CorTec Brain Interchange (BIC) System, we will examine the effect of a plasticity-inducing therapy regime on the rehabilitation of upper limb impairment post-stroke.
- Trial name
- MRPICS (NCT06506279)
- Testing
- CorTec Brain Interchange (BIC) System
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Washington
Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation
Measuring rTMS-induced Neuroplasticity With EEG Steady-state Visual-evoked Potentials
The goals of this study are to 1) use EEG steady-state visual evoked potentials as a noninvasive measure of the neuroplasticity induced by repetitive transcranial magnetic stimulation (rTMS), 2) use visual contrast detection…
- Conditions
- Visual Cortical Plasticity, Repetitive Transcranial Magnetic Stimulation, Visual Attention
- Trial name
- NCT05853939
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stroke
Paired Associative Stimulation in Stroke
Stroke is the third most common cause of death in the United States after heart disease and cancer, and the leading cause of long-term disability.
- Trial name
- NCT02586597
- Testing
- Transcranial magnetic stimulation & median nerve stimulation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Amyotrophic Lateral Sclerosis
Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is characterized clinically by abnormalities of both upper motor neurons (UMN) and lower motor neurons (LMN). The presence of UMN signs is not always easy to establish.
- Trial name
- NCT01959373
- Testing
- electroencephalograms (EEG), electro-myography (EMG)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson's Disease
Motor Skill Learning in People With Parkinson's Disease
This study will compare brain changes in people with Parkinson's disease with those of normal control subjects while they learn motor skills.
- Trial name
- NCT00396942
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Neuroregeneration Enhanced by Transcranial Direct Current Stimulation (TDCS) in Stroke
Testing the hypothesis that non-invasive brain stimulation by transcranial direct current stimulation (tDCS) combined with functional training in the subacute phase of first-ever stroke will enhance functional regeneration…
- Trial name
- NETS (NCT00909714)
- Testing
- DC-Stimulator to apply tDCS
- Where
- 11 sites in Austria, Germany and 1 more
- Volunteers
- 119 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Fecal Incontinence
Study of the Efficacy of 4 Treatments for Fecal Incontinence in Community-dwelling Women
This is a RCT aimed to assessing efficacy of kegel exercises,biofeedback, electrostimulation and transcutaneous neuromodulation on women with fecal incontinence, measuring its impact on anorectal physiology, cortical plasticity…
- Trial name
- NCT03394794
- Testing
- Pelvic floor rehabilitation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Amblyopia, Anisometropic Ambyopia
Visual Cortex Stimulation in Patients With Amblyopia
This study will examine whether direct current (DC) polarization (electrical stimulation) of the visual cortex can cause a temporary improvement of vision in an amblyopic eye of an adult.
- Conditions
- Amblyopia, Anisometropic Ambyopia, Amblyopia, Suppression
- Trial name
- NCT00097162
- Testing
- Anodal stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Eye Institute (NEI)
Blindness
Sensory Substitution and Brain Plasticity Following Vision Loss
The goal of this clinical investigation is to learn how the brain responds when visual information is converted into patterns of sound or touch in blind and sighted participants.
- Trial name
- SenSubMRI (NCT07450677)
- Testing
- Electrotactile display (BrainPort), Vision-to-sound converter (AI Sight)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Stroke
Amplitude Modulation Frequency Comparison in Kilohertz Transcranial Magnetic Perturbation (kTMP) for Chronic Stroke
Stroke is a leading cause of disability with many patients suffering chronic motor function impairments that affect their day-to-day activities.
- Trial name
- NCT07681102
- Testing
- kTMP
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Magnetic Tides
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cerebrovascular Accident
Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke
Recent studies have demonstrated that electrical stimulation delivered over the skin increases the muscle strength as measured by a dynamometer in chronic stroke patients.
- Trial name
- NCT00028379
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Effects of tDCS Over the Cerebellum on Motor Function
This study will evaluate whether applying electrical stimulation on the cerebellum (posterior and lower part of the brain) can influence brain excitability and hand movement performance.
- Trial name
- NCT00413842
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amelia of Upper Limb
Computer-aided and Mental Trainings Induced Plasticity of Sensorimotor Cortex in Patients Born Without Upper Limbs
This project will explore a potentially powerful trainings that may be administered before upper extremity transplantation to induced plasticity of sensorimotor cortex in humans with congenital absence of upper limbs.
- Trial name
- NCT04048083
- Testing
- Mental trainings, Computer-aided trainings, Computer-aided and mental trainings
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Stroke, RSS
Stimulate the Face to Improve Tactile Acuity on the Hand
The study is a comparative study, to show that the administration of RSS stimulation on the face compared to the administration of strategy Sham stimulation, results in an temporary improvement in the tactile acuity of the hand…
- Conditions
- Stroke, RSS, Face
- Trial name
- FACEHAND (NCT04745247)
- Testing
- RSS
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Brain Tumor
Use of Navigated Transcranial Magnetic Stimulation (nTMS) in Generated Motor and Language Mapping to Evaluate Brain Recovery Following Surgery
The goal of this clinical research study is to learn about using Navigated Transcranial Magnetic Stimulation (nTMS) in patients having surgery to remove a brain tumor in areas of the brain that control movement (motor function)…
- Trial name
- NCT02165995
- Testing
- Motor Mapping, Speech Mapping
- Sponsor
- M.D. Anderson Cancer Center
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Concussed Athletes, Healthy Controls
Influence of Transcranial Direct Current Stimulation on Cortical Plasticity in Concussed Athletes
Concussed athlethes have discrete decreased abilities in motor learning. Recent research could further show, that cortical plasticity, as measured by transcranial magnetic stimulation (TMS) is reduced.
- Trial name
- NCT01593956
- Testing
- tDCS
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Chronic Low Back Pain
Changes in Motor Cortex Following Exercises for Chronic Low Back Pain
The motor cortex of the brain changes following chronic pain and injury, and this is linked to pain-associated changes in motor behaviour.
- Trial name
- NCT00864422
- Testing
- Skilled motor training, Walking exercise
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- The University of Queensland
Amputation
Enhanced Tactile (Touch) Spatial Acuity in Upper Limb Amputees
This study will examine whether tactile (touch) abilities at the lip are more acute in people with upper limb amputation compared with healthy normal volunteers.
- Trial name
- NCT00028210
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)