Clinical trials: Cortisol
Hypercortisolism
Effects of Metyrapone in Patients With Hypercortisolism
The aims of the present study are to evaluate in patients with mild hypercortisolism the effect of metyrapone treatment on glycometabolic control, blood pressure, thrombotic risk parameters, lipid profile, bone turnover markers…
- Trial name
- CEM (NCT05255900)
- Testing
- Metyrapone Capsules
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Asthma
Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver Function
The proposed study is designed to investigate the pharmacokinetics, pharmacodynamics (as measured by serum cortisol) and safety of GW685698X in subjects with moderate hepatic impairment and in healthy subjects following a single…
- Trial name
- NCT00419237
- Testing
- GW685698X
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anxiety
Virtual Reality to Reduce Intraoperative Anxiety in Vasectomies Under Local Anesthesia
Vasectomy is an elective and ambulatory surgery, typically performed under local anaesthesia. The most common problem that we have found among patients is the anxiety and the apprehension to face the procedure.
- Trial name
- NCT06749353
- Testing
- Virtual reality
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Hospital Mutua de Terrassa
Adrenocortical Carcinoma
Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)
This study will investigate the safety and efficacy of Relacorilant in combination with Pembrolizumab for Patients with Adrenocortical Carcinoma which Produces Too Much Stress Hormone (Cortisol).
- Trial name
- NCT04373265
- Testing
- Relacorilant, Pembrolizumab
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Corcept Therapeutics
Familial Partial Lipodystrophy Type 2
Study of Cortisol Metabolism in Familial Partial Lipodystrophy Type 2
Familial partial lipodystrophic syndromes are characterized by an increase in visceral adipose tissue and an atrophy of subcutaneous adipose tissue.
- Trial name
- LIPOCORT (NCT04845165)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Lille
Postpartum Depression (PPD)
Moringa Oleifera and Phoenix Dactylifera L. Effects on Cortisol and Breast Milk in Postpartum Depression
Postpartum depression affects 10-20% of new mothers globally, potentially disrupting breast milk production. This study aimed to provide valuable insights into effective interventions to improve the health and well-being of…
- Trial name
- NCT07337512
- Testing
- Phoenix dactylifera L, Moringa oleifera
- Where
- Indonesia
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- Melania Asi
Adrenal Insufficiency
Neonatal, Infant and Toddler Salivary Study (NITS Study)
Currently, the only way to analyse glucocorticoids for the screening or diagnosis of AI in young children is via plasma obtained by invasive capillary or venous blood sampling.
- Trial name
- NITS (NCT05350982)
- Testing
- SalivaBio +/- SaliPac
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Children's NHS Foundation Trust
Posttraumatic Stress Disorder
Low-dose Cortisol in Chronic Posttraumatic Stress Disorder
The aim of this prospective, double-blind, placebo-controlled, cross-over study is to determine the therapeutic efficacy of low-dose cortisol for symptoms of chronic posttraumatic stress disorder.
- Trial name
- NCT00362661
- Testing
- Cortisol
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Depressive Disorder, Major, Depression
The Effect of Probiotic Supplementation on the Mental Status, Inflammation, and Intestinal Barrier in Major Depressive Disorder Patients Using Gluten-free or Gluten-containing Diet
More and more evidence confirms the relationship between the gut-brain-microbiota axis and the symptoms of mood disorders. A potential pathway connecting the intestines and the brain in depression is inflammation.
- Trial name
- SANGUT (NCT03877393)
- Testing
- Probiotic supplementation + gluten-free diet, Probiotic supplementation + gluten-containing diet
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Lublin
Premenstrual Syndrome
Effect of Aerobic Exercise on Diurnal Cortisol Pattern in Premenstrual Syndrome
The aim of this study will be to investigate the effect of aerobic exercise on diurnal cortisol pattern in premenstrual syndrome.
- Trial name
- NCT05507255
- Testing
- Relaxation training, An aerobic exercise program
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
GI Motility Disorder
Effect of CRH on Duodenal Markers and Gastric Sensorimotor Function
In the present study, during Part 1, after a baseline gastroduodenoscopy, the investigators will perform a gastroduodenoscopy twice, to take duodenal biopsies before and 2 hours after administration of CRH/placebo.
- Trial name
- NCT05071781
- Testing
- Corticotropin-release hormone
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prevention of the Procedural Pain in the Newborn
Prevention of the Procedural Pain in the Newborn
The aim of this study is to compare the impact of two non-medicinal strategies: the breast-feeding and saccharose to measure effects in cerebral cortex during pain using near infrared spectroscopy (NIRS)
- Trial name
- ACTISUCROSE (NCT02109263)
- Testing
- saccharose versus breast-feeding
- Where
- France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Brest
Stress, Psychological
Effect of Low Doses of Vitamin C on Salivary Cortisol , Heart Rate , Blood Pressure During Group Presentation
Vitamin C (ascorbic acid) is a well-known antioxidant that is involved in anxiety, stress, depression, fatigue and mood state in humans .
- Trial name
- NCT04135378
- Testing
- ascorbic acid
- Where
- Iraq
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kufa University
Breastfeeding
Effect of Early Skin to Skin Contact on Breast Feeding Behaviour in Term Newborns: A Randomized Controlled Trial
Aims and Objectives Aim To determine the effect of delivery room Skin To Skin contact on breast feeding behavior of term neonates born by normal vaginal delivery at 36-48 hours.
- Trial name
- NCT00776789
- Testing
- skin to skin contact, Control group
- Where
- India
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Osteopenia of Prematurity
The Effect of Daily Exercise Program on Bone Mineral Density and Cortisol Level in Preterm Infants
ABSTRACT Objective: This randomized controlled double-blinded experimental study was carried out to determine the effects of daily exercise program on bone mineral density and cortisol level in preterm infants with very low birth…
- Trial name
- NCT03773679
- Testing
- Daily Exercise
- Volunteers
- 24 people
- Sponsor
- TC Erciyes University
Cushing Disease
Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms
Automated immunodosage methods (Roche Elecsys cortisol and IDS cortisol dosing kits) offer a simple and inexpensive technology routinely used in a medical biology laboratory.
- Trial name
- COSHING (NCT03974789)
- Testing
- Blood test, 24-hour Urine test, Saliva swab
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cardiac Output, Low
Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Babies having heart surgery often have problems after surgery with their blood pressure and getting enough blood to their bodies.
- Trial name
- Corti (NCT00590018)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Necrotizing Soft Tissue Infection, Sepsis
HAT for the Treatment of Sepsis Associated With NASTI
Evaluate the impact of HAT therapy versus placebo in the treatment of patients with an acute NSTI and sepsis.
- Trial name
- NCT05157360
- Testing
- HAT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ascension Health
Depression, Sleep
The Long-term Effects of Body-mind-spirit Group Therapy
Aims and objectives: This study aims to examine the effects of the body-mind-spirit group therapy on marital close relationships, sleeping quality, depression, quality of life, meaning of life, and salivary cortisol levels in…
- Trial name
- NCT01727635
- Testing
- body-mind-spirit group therapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Pediatric Cancer
Efficacy Of Child Yoga Programme on Quality of Life of Pediatric Oncology Patients.
Pediatric oncology patients experience physical and psycho-social symptoms that negatively affect their quality of life during treatment.
- Trial name
- NCT04932720
- Testing
- chıld yoga programme
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
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