Clinical trials: Cortisol
Adrenal Incidentaloma, Hypercortisolism
Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations
The investigators hypothesize that cardiovascular and metabolic alterations can occur in patients with adrenal adenomas and possible Autonomous Cortisol Secretion (pACS).
- Conditions
- Adrenal Incidentaloma, Hypercortisolism, Adrenal Tumor
- Trial name
- ITACA (NCT04127552)
- Testing
- Adrenalectomy
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Yohimbine, Hydrocortisone
The Role of Stress Neuromodulators in Decision Making Under Risk and Selective Attention to Threat
Incidental affective states, i.e., affective states can influence decision making and selective attention to threatening information.
- Conditions
- Yohimbine, Hydrocortisone, Yohimbine + Hydrocortisone, Placebo
- Trial name
- SID (NCT04359147)
- Testing
- "Yohimbine", "Hydrocortisone", "Yohimbine + Hydrocortisone"
- Where
- Germany
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Preeclampsia, Stress, Psychological
Stress Reduction in Formerly Preeclamptic Women; Sofa or Sports
The goal of this clinical trial is to evaluate stress and cardiovascular risk factors in women with preeclampsia in the medical history.
- Conditions
- Preeclampsia, Stress, Psychological, Stress, Physiological, Sports Physical Therapy
- Trial name
- SOS (NCT06402604)
- Testing
- Aerobic exercise training, Mindfulness Based Stress Reduction training
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Primary Adrenal Insufficiency, Secondary Adrenal Insufficiency
Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)
This is a randomized, controlled, open, three-armed, multi-centre study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on anthropometric parameters…
- Trial name
- DREAM (NCT02277587)
- Testing
- Plenadren, Conventional glucocorticoid therapy
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Sepsis
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
In this prospective clinical study, the investigators compare the outcome and clinical course of consecutive septic participants treated with intravenous vitamin C, hydrocortisone, and thiamine (treatment group) with a control…
- Trial name
- HYVCTTSSS (NCT03258684)
- Testing
- Hydrocortisone, Vitamin C, and Thiamine, Normal saline
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Functional Constipation
Core-Based Movement and Nutritional Counselling for Stress and Metabolic Outcomes in Overweight Women With Functional Constipation
This study will investigate the effect of core-based movement and nutritional counselling on stress, serum cortisol, and lipid profile in overweight women with functional constipation.
- Trial name
- NCT07694830
- Testing
- Guideline-Based Nutritional Counselling, Core-Based Movement Exercise Program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Nursing Caries
Effect of Laughter Yoga on Mental Symptoms Frequency and Level of Saliva Cortisol
The aim of this study is to evaluate the effect of laughter yoga on mental symptom frequency and salivary cortisol level among the 1st Year Nursing Students.
- Trial name
- NCT03814265
- Testing
- Laughter yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ankara University
Symmetric Lipomatoses, Multiple
Hydrocortisone Treatment for Symmetric Lipomatosis Associated With Neuropathy (SLN): an N-of-1 Study Hydrocortisone Treatment for Symmetric Lipomatosis Associated With Neuropathy (SLN): an N-of-1 Study
A young women with Symmetric Lipomatosis associated with Neuropathy (SLN) was seen at the department of Internal Medicine - Endocrinology and at the department of Neurology at the Erasmus MC, Rotterdam, the Netherlands.
- Trial name
- N-of-1 SLN (NCT04821583)
- Testing
- Hydrocortisone
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Erasmus Medical Center
Acute Aluminum Phosphide Poisoned Cases
Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals.
Metal phosphides are commonly utilized for safeguarding stored grains due to their desirable characteristics. They have high potency and the ability to combat different pests and produce non-toxic residues in crops .
- Trial name
- NCT07451561
- Testing
- Gastric lavage with paraffin oil, GIK solution
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Sohag University
Headache
Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache
Fifty patients of both sex, aged 18-50 years and ASA I and II undergoing elective lower abdominal and pelvic surgery under spinal anesthesia were included in this randomized double-blind study.
- Trial name
- NCT02760862
- Testing
- hydrocortisone 100mg., mannitol 20% intravenous fluid
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Adrenal Insufficiency
An Investigational Study of Hydrocortisone
This study will investigate a new drug called Infacort®; a newly-developed immediate release formulation of a well-established drug called hydrocortisone.
- Trial name
- NCT01960530
- Testing
- Hydrocortisone granules, Hydrocortisone Tablet, i.v. Hydrocortisone Injection
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Adrenal Insufficiency, Adrenal Cancer
Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated Patients
In mitotane treated patients, serum cortisol cannot be used to diagnose hypoadrenalism, since mitotane increases cortisol binding globulin levels (CBG), artificially raising total cortisol.
- Trial name
- NCT03083834
- Testing
- Cosyntropin stimulation test
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Heart Arrest
Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) is an important issue for the emergency physicians and co-workers. How to improve the return of spontaneous circulation (ROSC) rate and prognosis of these patients challenges the emergency…
- Trial name
- NCT00172354
- Testing
- Hydrocortisone
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Sepsis, Alcoholism
Relationship Between Alcohol Use Disorders and Cortisol Levels in Patients With Sepsis
Patients with alcohol use disorders are often cared for in the intensive care unit (ICU). We estimate that close to half of the patients we care for in our ICU have alcohol use disorders.
- Trial name
- NCT00615862
- Testing
- Observational study; no interventions
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Post-Traumatic Stress Disorders, Healthy
Effects of Hydrocortisone in Patients With Post-Traumatic Stress Disorder
The purpose of this study is to determine whether people who develop Post-Traumatic Stress Disorder (PTSD) after a trauma have increased sensitivity to the effects of a stress hormone.
- Trial name
- NCT00039715
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Critical Illness
Cortisol Levels as a Measure of Accumulated Physiological Stress in ICU Patients Undergoing Mechanical Ventilation
Critical illness is a situation of severe and prolonged stress for patients with mechanical ventilation (MV). Between 40-80% of these patients present the Post-ICU syndrome, a set of physical, cognitive, psychological alterations…
- Trial name
- Corti-COG (NCT03736135)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Corporacion Parc Tauli
Bronchopulmonary Dysplasia
PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates
There is increasing evidence linking a fetal and early neonatal systemic inflammatory response syndrome to the subsequent development of bronchopulmonary dysplasia (BPD) and white matter injury (WMI) in very preterm infants.
- Trial name
- PREMILOC (NCT00623740)
- Testing
- hydrocortisone
- Where
- France
- Volunteers
- 523 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sedentary Behavior, Acute Exercise
Acute Endocrine Responses to Aerobic and Anaerobic Exercise in Sedentary Women: A Comparative Analysis of Thyroid Hormones and Cortisol
This study aims to compare acute thyroid hormone and cortisol responses to aerobic and anaerobic exercise in sedentary women. Thirty sedentary women aged 18-25 years will voluntarily participate in the study.
- Conditions
- Sedentary Behavior, Acute Exercise, Endocrine Response
- Trial name
- AERAE (NCT07823335)
- Testing
- 20-Meter Shuttle Run Test, Wingate Anaerobic Test
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Assoc. Prof. Dr. Özgür EKEN
Malocclusion
Salivary Stress Markers Associated With Malocclusion Severity
The aim of this observational study is to evaluate the relationship between the severity of orthodontic malocclusion and psychophysiological stress levels in individuals aged 12 to 18 years.
- Trial name
- NCT07116317
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
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