Clinical trials: Cortisol
Adrenal Insufficiency
Hydrocortisone Vs Prednisolone in AI (HYPER-AID)
This study is designed to collect data on individuals with adrenal insufficiency who are changing treatments from hydrocortisone to prednisolone, or vice versa.
- Trial name
- HYPER-AID (NCT03608943)
- Testing
- There is no specific intervention other than an individual changing their treatment as part of their usual care
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Laparoscopic Gynecological Surgery
Analgesic Effect of Pulmonary Recruitment and Intraperitoneal Hydrocortisone in Laparoscopic Gynecological Surgery
The aim of this study is to compare the postoperative analgesic efficacy of intraperitoneal hydrocortisone to pulmonary recruitment maneuver in Laparoscopic gynaecological surgery.
- Trial name
- NCT03845608
- Testing
- Pulmonary Recruitment Maneuver
- Volunteers
- 45 people
- Sponsor
- Cairo University
Prostate Adenocarcinoma, Recurrent Prostate Carcinoma
Calcitriol in Combination With Ketoconazole and Therapeutic Hydrocortisone in Treating Patients With Prostate Cancer
This phase I/II trial studies the side effects and best dose of calcitriol when given in combination with ketoconazole and therapeutic hydrocortisone and to see how well it works in treating patients with prostate cancer.
- Conditions
- Prostate Adenocarcinoma, Recurrent Prostate Carcinoma, Stage III Prostate Cancer, Stage IV Prostate Cancer
- Trial name
- NCT00536991
- Testing
- Calcitriol, Ketoconazole, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Roswell Park Cancer Institute
Pregnancy
Effect of Maintenance of Intraoperative Normothermia in Cesarean Section on Thermal Comfort, Serum Cortisol and Apgar Score: A Randomized Controlled Trial
Cesarean section is a common method of delivery worldwide today. According to WHO, cesarean section accounts for more than 1 in 5 (21%) of all births, and it is predicted that approximately one-third (29%) of births will be by…
- Trial name
- NCT06962241
- Testing
- Warming group
- Volunteers
- 50 people
- Sponsor
- Kocaeli University
Spinal Anesthesia, Knee Arthroplasty
Effect of Music Listened During Knee Arthroplasty With Spinal Anesthesia on Anxiety, Pain and Cortisol Levels
The aim of this study is to examine the effects of binaural beat music played during spinal anesthesia knee arthroplasty on anxiety, pain and cortisol levels.
- Trial name
- NCT06729294
- Testing
- Binaural beat music recital
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Nuh Naci Yazgan University
Exercise
Effects of HIIT and MICT Training on Cardiorespiratory Fitness, Testosterone/Cortisol Ratio, and Mental Health in Young Adults
This study will use a randomized, double-blind clinical trial to evaluate the effects of eight-week HIIT and MICT exercise programs on cardiorespiratory fitness, the testosterone/cortisol ratio, and mental health in 68 healthy…
- Trial name
- NCT07397702
- Testing
- High-intensity interval training, Moderate-intensity continuous training
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Dry Eye, Meibomian Gland Dysfunction
Efficacy and Safety of Topical Hydrocortisone on Signs and Symptoms of Dry Eye Associated to Meibomian Gland Dysfunction
The purpose of this study is assess the efficacy and safety of topical hydrocortisone (Softacort) for treatment of clinical signs and symptoms of dry eye disease when associated with moderate meibomian gland dysfunction.
- Trial name
- NCT05159284
- Testing
- Hydrocortisone Ophthalmic, MGD Rx EyeBag® eyelid warming device, Lephanet® lid wipes
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Laboratorios Thea, Spain
Alcohol Drinking, Alcohol Abuse
Novel Real-world Methods in Social Drinkers and AUD
This research project proposes a novel approach to elucidate the biological adaptations associated with Alcohol Use Disorder and to assess whether such adaptations are predictive of higher alcohol craving in response to both…
- Conditions
- Alcohol Drinking, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- ALR (NCT05155176)
- Testing
- Intensive Day Monitoring
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Yale University
Postpartum Depression, Insomnia
Poor Sleep During Pregnancy as Risk Factor for Post-partum Stress and Mental Health
Improving maternal mental health is a worldwide health priority. Nevertheless, several scientific sources highlighted lack of empirical data which could drive clinical practice.
- Conditions
- Postpartum Depression, Insomnia, Stress
- Trial name
- MOTHERS (NCT06379074)
- Testing
- Improving sleep health and resilience during pregnancy, Information on pregnancy-related issues
- Where
- 2 sites in Italy
- Volunteers
- 114 people
- Sponsor
- University of Rome G. Marconi
Dermatitis, Atopic, Pruritus
The Efficacy of 3% Kanuka Oil Versus 1% Hydrocortisone Cream in Patients With Atopic Dermatitis
Atopic dermatitis is a common disease affecting millions worldwide. A common associated symptom in this population is pruritus. We seek to investigate the use of an natural, over-the-counter cosmeceutical to help this population
- Trial name
- NCT06488742
- Testing
- 3% kanuka oil
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nexgen Dermatologics, Inc.
Systemic Inflammatory Response Syndrome, Hyperglycemia
The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis
Hyperglycemia is frequent manifestations of the human metabolic response to systemic inflammatory response syndrome (SIRS),sepsis and septic shock, and are implicated in the clinical outcome.
- Trial name
- AM (NCT00459511)
- Testing
- Blood AM, IL-6, ACTH, Cortisol, Glucose and Insulin
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Stress
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient way to evaluate the biological impact of day-to-day stressors that people encounter as they go about their lives, since saliva is so easy…
- Trial name
- NCT01673087
- Testing
- Metyrapone, Dexamethasone, Cortrosyn
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Appearance of Facial Wrinkles, Aesthetic
Evaluation of a Non-cross-linked Hyaluronic Acid Medical Device ("Electri" and "XELA REDERM") for Improving Facial Skin Appearance
The goal of this clinical investigation is to learn whether injectable implants based on non-cross-linked hyaluronic acid (Electri and XELA REDERM) improve the aesthetic appearance of facial skin in adult women.
- Conditions
- Appearance of Facial Wrinkles, Aesthetic, Hydration, Facial Skin Wrinkles
- Trial name
- RegHyal-01 (NCT06984432)
- Testing
- XELA REDERM (non-cross-linked hyaluronic acid 1.1%, 1.8%, or 2.2%), Electri (non-cross-linked hyaluronic acid 0.55%)
- Where
- 4 sites in Poland, Ukraine
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Institute Hyalual GmbH
Disorder of Endocrine Ovary, Hypersecretion; Cortisol
Pathogenesis of Functional Hypothalamic Amenorrhea
This is a randomized pilot study of the use of cognitive behavior therapy versus observation to treat functional hypothalamic amenorrhea, often termed stress-induced anovulation.
- Conditions
- Disorder of Endocrine Ovary, Hypersecretion; Cortisol, Metabolic Disturbance, Stress, Psychological
- Trial name
- NCT01674426
- Testing
- Cognitive behavior therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
Primary Prevention, Stress
Efficacy of Taiji Training as a Program for Stress Prevention
Background: Excessive exposure to psychosocial stress can be a potent trigger for somatic diseases and psychological disorders, a cause for missing work, and eventually lead to high economic loss.
- Conditions
- Primary Prevention, Stress, Tai ji, Adult
- Trial name
- NCT01122706
- Testing
- Taiji training
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Bern
Type 2 Diabetes, Cortisol Excess
Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)
CAPTAIN-T2D will take place in two parts. Part 1 (Screening) will evaluate patients with type 2 diabetes and elevated cortisol risk factors for trial eligibility and the presence of elevated cortisol.
- Trial name
- CAPTAIN-T2D (NCT07296484)
- Testing
- clofutriben
- Where
- 61 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Sparrow Pharmaceuticals
Mother-Infant Interaction
Response of Preterm Infants to Multisensory Stimuli
The aim of this study is to measure the variation of oxytocin and cortisol levels in the saliva of premature neonates and their mother after sensorial stimuli.
- Trial name
- OXYVOICE (NCT04665440)
- Testing
- Voice alone, Voice + tactile stimuli
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University Hospital, Geneva
Sleep, Wearable Technology
Effects of PeptiSleep on Sleep Quality in Healthy Adults
Examining the effects of PeptiSleep, a plant-based sleep aid, on sleep quality in healthy adults
- Conditions
- Sleep, Wearable Technology, Cortisol, Healthy Participants
- Trial name
- NCT07258433
- Testing
- PeptiSleep, Micro-crystalline cellulose
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nuritas Ltd
Major Depressive Disorder, Major Depressive Disorder w/ Psychotic Features
Risks for Insulin Resistance and Metabolic Syndrome Between Major Depressive Disorder (MDD) or MDD With Psychotic Features
Studies have shown that people with certain disorders have an increased risk of developing a condition called Metabolic Syndrome (MS).
- Conditions
- Major Depressive Disorder, Major Depressive Disorder w/ Psychotic Features, Metabolic Syndrome
- Trial name
- NCT01310140
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Molar Incisor Hypomineralization
Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment.
- Trial name
- NCT07389148
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
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