Clinical trials: Cortisol
Sleep Restriction
Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction and 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with…
- Trial name
- NCT04037605
- Testing
- Ketoconazole Pill (also known as nizoral), Ganirelix, Dexamethasone Pill
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Postoperative Pain, Stress, Psychological
Effect Of Electroacupuncture With Local Anesthesia On Pain And Stress During Impacted Lower Third Molar Surgery
This randomized controlled trial investigates the effect of electroacupuncture as an adjunct to local anesthesia on perioperative pain and stress during ambulatory surgical extraction of impacted lower third molars.
- Conditions
- Postoperative Pain, Stress, Psychological, Impacted Lower Third Molar
- Trial name
- EASE (NCT07509294)
- Testing
- Electroacupuncture
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University of Zagreb
Diabetes Mellitus, Stress
Effect of Breathing and Relaxation Exercises on Serum Cortisol Levels in Type 2 Diabetic Patients
Background: Diabetes is a fast-growing health problem in Egypt with a significant impact on morbidity, mortality, and health care resources.
- Trial name
- NCT05231031
- Testing
- Aerobic exercise, breathing exercise, Relaxation training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Mild Autonomous Cortisol Secretion Adenoma, Non Secreting Adenoma
Ultradian Steroid Rhythms in Adrenal Incidentalomas
Twenty to 40% of adrenal incidentalomas are responsible for MACS (mild autonomous cortisol producing secretion). The biological tools used in current practice to explore MACS do not provide precise information on cortisol…
- Trial name
- CHRONOMACS (NCT07387419)
- Testing
- U-RYTHM system
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Yohimbine, Hydrocortisone
The Role of Stress Neuromodulators in Decision Making Under Risk and Selective Attention to Threat
Incidental affective states, i.e., affective states can influence decision making and selective attention to threatening information.
- Conditions
- Yohimbine, Hydrocortisone, Yohimbine + Hydrocortisone, Placebo
- Trial name
- SID (NCT04359147)
- Testing
- "Yohimbine", "Hydrocortisone", "Yohimbine + Hydrocortisone"
- Where
- Germany
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Primary Hyperaldosteronism
Intraoperative Analysis of Cortisol During Adrenal Vein Sampling
Aldosterone is a hormone produced in the adrenals that helps regulate the salt balance and blood pressure. Primary hyperaldosteronism is one of the main endocrine causes of secondary hypertension.
- Trial name
- NCT01761344
- Testing
- Intraoperative cortisol measurement.
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Haukeland University Hospital
Infant, Newborn, Hypotension
Hypotension in Neonates
This observational study collects information on the current incidence and management of hypotension in babies born at term or late preterm that are admitted to Neonatal Intensive Care Units (NICUs) within the Neonatal Research…
- Conditions
- Infant, Newborn, Hypotension, Blood Pressure
- Trial name
- NCT00882284
- Where
- 17 sites in United States
- Volunteers
- 820 people
- Sponsor
- NICHD Neonatal Research Network
Type 1 Diabetes
Role of Pregnancy Related Hormones in Lowering the Insulin Requirement in Pregnant Women With Type 1 Diabetes
This is a randomized, double-masked, placebo-controlled, single-center study to evaluate stimulated C-peptide secretion after exogenous administration of mild immunosuppression and growth-promoting factors to women with…
- Trial name
- NCT01265017
- Testing
- Estradiol, medroxyprogesterone, hydrocortisone, GH
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Maternal-Fetal Relations
The Efficacy of Maternal Sound for Pediatric Patients Undergoing Cardiac Surgery
A newborn's recognition and preference for their mother's voice occurs early in life, very likely during fetal development. Maternal voice stimuli undergo a unique form of cerebral processing that lends support for the existence…
- Trial name
- NCT02674126
- Testing
- Control group, Maternal sound group
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Assiut University
Soft Tissue, Peri-Implant Health
Evaluation of Multilayered PRF in Comparison With Connective Tissue Graft by Sohn Poncho's Technique on Peri-implant Mucosal Enhancement in the Esthetic Zone
An effective biological seal is crucial for protecting and supporting dental implants, particularly in the anterior region for the desired esthetic outcome.PRF membrane and CTG has been utilized to improve peri-implant soft…
- Conditions
- Soft Tissue, Peri-Implant Health, Soft Tissue Augmentation at Dental Implants, Connective Tissue Graft
- Trial name
- NCT07649239
- Testing
- Platelet rich fibrin multilayered Platelet-rich fibrin (PRF) A t the second stage, Soft tissue augmentation around dental implants with CTG in the second stage
- Where
- United Arab Emirates
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Sleep Restriction
Hormonal Mechanisms of Sleep Restriction - Axis Study
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with…
- Trial name
- NCT03142893
- Testing
- Ketoconazole Pill, Ganirelix, Dexamethasone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peter y. Liu
Patients With at Least Single Missing Anterior Tooth, Thin Gingival Biotype
Clinical Evaluation of Platelet Rich Fibrin Versus Subepithelial Connective Tissue Graft for Soft Tissue Augmentation
Soft tissue biotype is a critical factor for success of implant in the esthetic zone . Different soft tissue augmentation techniques have been employed to increase soft tissue thickness such as: autogenous grafts, allografts…
- Trial name
- NCT03219944
- Testing
- Platelet Rich Fibrin, sub epithelial connective tissue graft
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
Effects of Stress Hormones on Emotion and Cognition
The purpose of this study is to examine how hormonal changes that occur during stressful situations affect thought and emotions.
- Trial name
- NCT00032838
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Sleep Deprivation, Gut Microbiota
Microbiota Profiles in Newly Married Couples: Potential Effects on Vision, Sleep and Psychometric Parameters
Oral, fecal and conjunctival samples will be collected from participants and will be stored (at - 20 and - 80 ◦C) until further processing.
- Conditions
- Sleep Deprivation, Gut Microbiota, Optometry Examinations, Oral Microbiota
- Trial name
- NCT06638606
- Testing
- Sleep improvement techniques
- Where
- Iran
- Volunteers
- 1,740 people, healthy volunteers welcome
- Sponsor
- Reza Rastmanesh
Metabolic Syndrome, Obesity
Cortisol and Nutritional Sympathetic Responsiveness
This project will examine whether short-term (over a 12-hour period) pharmacological lowering of the stress hormone 'cortisol' improves the nervous system response to food intake in overweight or obese individuals who have…
- Conditions
- Metabolic Syndrome, Obesity, Insulin Resistance
- Trial name
- NCT01620684
- Testing
- metyrapone
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Baker Heart Research Institute
Endothelial Dysfunction
The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.
The study aimed to check the influence of timing and composition of diet on markers of gut injury, endotoxemia and stress.
- Trial name
- NCT06403241
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Parkinson's Disease, Apomorphine-induced Skin Reactions
Treatment of Apomorphine-induced Skin Reactions: a Pilot Study
Skin reactions as a result of continuous subcutaneous apomorphine infusion occur frequently and interfere with the absorption of apomorphine. The histopathology of apomorphine-induced skin reactions is poorly understood.
- Trial name
- NCT02230930
- Testing
- Apomorphine 0.25% (2.5mg/ml), Massage with a spiky ball, Hydrocortisone cream 1%
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- University Medical Center Groningen
Cushing's Syndrome I, Cushing Disease Due to Increased ACTH Secretion
SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome
This is a randomized, placebo-controlled, study of SPI-62 in subjects with ACTH-dependent Cushing's syndrome caused by a non-adrenal tumor.
- Conditions
- Cushing's Syndrome I, Cushing Disease Due to Increased ACTH Secretion, Cortisol Excess, Cortisol; Hypersecretion
- Trial name
- RESCUE (NCT05307328)
- Testing
- SPI-62
- Where
- 12 sites in United States, Bulgaria and 1 more
- Volunteers
- 26 people
- Sponsor
- Sparrow Pharmaceuticals
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