Clinical trials: Cortisol
Jet Lag
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag
This study will examine the effects of cortisol (hydrocortisone), melatonin, a combination of cortisol and melatonin, and placebo (an inactive substance) on jet lag symptoms.
- Trial name
- NCT00097474
- Testing
- Hydrocortisone, Melatonin
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Adrenal Insufficiency
Neonatal, Infant and Toddler Salivary Study (NITS Study)
Currently, the only way to analyse glucocorticoids for the screening or diagnosis of AI in young children is via plasma obtained by invasive capillary or venous blood sampling.
- Trial name
- NITS (NCT05350982)
- Testing
- SalivaBio +/- SaliPac
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Children's NHS Foundation Trust
Psoriasis Vulgaris
Effect of Calcipotriol Plus Hydrocortisone Ointment on the Adrenal Hormone Balance and Calcium Metabolism in Patients With Psoriasis Vulgaris on the Face and Skin Folds
There are few therapies suitable for the treatment of psoriasis on the face and skin folds. As these areas are sensitive, irritation and other adverse reactions are more common than elsewhere on the body.
- Trial name
- NCT00704262
- Testing
- Calcipotriol plus hydrocortisone (LEO 80190)
- Where
- 11 sites in United States, Canada and 2 more
- Volunteers
- 33 people
- Sponsor
- LEO Pharma
Shock
Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study
Approximately 20,000 children per year in North America present to the hospital with severe shock. Children who develop this condition have very low blood pressures and as a result may suffer damage to their internal organs and…
- Trial name
- STRIPES (NCT02044159)
- Testing
- Hydrocortisone
- Where
- 7 sites in Canada
- Volunteers
- 57 people
- Sponsor
- Children's Hospital of Eastern Ontario
Renin Angiotensin
Effects of Fludrocortisone and Hydrocortisone in Healthy Volunteers With Aldosterone Induced Suppression
Septic shock (associated with relative adrenal insufficiency) is characterized by decreased arterial responsiveness to catecholamines.
- Trial name
- AFLUCO2 (NCT00673270)
- Testing
- Fludrocortisone, Hydrocortisone
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
Longitudinal Study of Cortisol and Pulmonary Function
To conduct a longitudinal study of the relationship between the rate of decline of pulmonary function and measurements of cortisol concentration and excretion in a sample of middle-aged and older men and their wives.
- Trial name
- NCT00005370
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Immunosuppression, Healthy
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers
Background: Corticosteroids have been used to treat inflammation and immune system diseases for decades. However, despite their widespread use, there is little information on the specifics of how corticosteroids affect the immune…
- Conditions
- Immunosuppression, Healthy, Healthy Subjects
- Trial name
- NCT01281995
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
The Primary Condition Studied for This Trial is Acute Stress
Efficacy Study of Zeller Entspannung Film Coated Tablets on Acute Stress
The objective of the STRESS trial is to investigate in a mode of action setting the effect of Zeller Entspannung film coated tablets on saliva cortisol response versus Placebo after acute stress in healthy male volunteers.
- Trial name
- NCT02189239
- Testing
- Zeller Entspannung film coated tablet, No Treatment
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Max Zeller Soehne AG
Pancreas Head Cancer, Pancreas Adenocarcinoma
Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)
The PANENCA trial aims to reduce postoperative complications in patients undergoing pancreatoduodenectomy (also known as a Whipple procedure), a complex surgical operation performed to remove tumors located in or near the head of…
- Conditions
- Pancreas Head Cancer, Pancreas Adenocarcinoma, IPMN, Pancreatic, Cholangio Carcinoma
- Trial name
- PANENCA (NCT07262957)
- Testing
- HOP bundle
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ISCHEMIC STROKE
Hair Cortisol and the Risk of Stroke
The purpose of this study is to prospectively examine the relation between ischemic stroke and hair cortisol concentration. The investigators hypothesize that patients with ischemic stroke have higher levels of hair cortisol…
- Trial name
- NCT02090270
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Cushing Syndrome, Primary Aldosteronism
Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders
The goal of this project is to provide novel technology that will pave the way from the present single-point (analogue) endocrinology towards continuous cortisol and aldosterone monitoring with full time resolution.
- Conditions
- Cushing Syndrome, Primary Aldosteronism, Adrenal Insufficiency
- Trial name
- NCT06980753
- Testing
- Participants will use the biossensor for 48 h
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Bone Loss, Flap Design
The Effect Of Vertical Releasing Incision On Implant Procedures
This study evaluated the clinical and biochemical aspects of flap design in dental implant applications regarding implantation success and patient comfort.
- Trial name
- Vertikal (NCT06322901)
- Testing
- Flap
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Gynecologic Laparoscopic Surgery
COMPARISON OF OXIDANT-ANTIOXIDANT LEVELS WITH STRESS HORMONES IN SPINAL ANESTHESIA AND GENERAL ANESTHESIA IN LAPAROSCOPIC TUBE LIGATION
The aim of this observational study is to investigate the effect of anesthesia method applied in laparoscopic tubal ligation on stress factors in women aged 15-45.
- Trial name
- LAP TUBE LİG (NCT06710522)
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people
- Sponsor
- KADİR TEOMAN
Adrenal Hyperplasia, Congenital
Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia
The conventional glucocorticoid replacement therapy in congenital adrenal hyperplasia (CAH) renders the cortisol levels unphysiological, which may cause symptoms and long-term complications.
- Trial name
- CAH (NCT01771328)
- Testing
- Hydrocortisone, Cortisone acetate
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Haukeland University Hospital
Endocrine Disease
New Clinical Decision Support Score Based on Steroid Hormone Profiling in the Diagnosis of MACS
The recent development of quantitative steroid metabolome profiling could be of interest for the positive diagnosis of mild autonomous cortisol-secreting adenoma (MACS).
- Trial name
- MACSCORE (NCT07352527)
- Where
- France
- Volunteers
- 291 people
- Sponsor
- University Hospital, Bordeaux
Dental Anxiety, Dental Fear
Comparing Augmented Reality and Virtual Reality Glasses to Help Children Feel Less Pain and Anxiety During Local Anesthesia
The goal of this clinical trial is to learn if audio-visual method of distraction is useful to control the pain and fear associated with dental treatment in children.
- Conditions
- Dental Anxiety, Dental Fear, Dental Fear and Anxiety
- Trial name
- NCT07060170
- Testing
- Augmented Reality Glasses, Virtual Reality Glasses
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riham Abbas
Pregnancy Related
Does Endorphin Massage Reduce the Anxiety of Pregnant Women?
Before cesarean section surgery, researchers will demonstrate endorphin massage to the husbands of pregnant women, and they will be asked to apply the massage before the surgery.
- Trial name
- NCT06342154
- Testing
- Endorphin Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Manisa Celal Bayar University
Psoriasis Vulgaris
Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment in Psoriasis Vulgaris on the Face and Skin Folds
There are few therapies suitable for the treatment of psoriasis on the face and skin folds. As these areas are sensitive, irritation and other adverse reactions are more common than elsewhere on the body.
- Trial name
- NCT00691002
- Testing
- Calcipotriol plus hydrocortisone (LEO 80190), LEO 80190 Vehicle, Hydrocortisone
- Where
- 11 sites in Croatia, Germany and 2 more
- Volunteers
- 1,245 people
- Sponsor
- LEO Pharma
Infant, Newborn, Diseases, Cardiovascular Insufficiency
Hydrocortisone for Term Hypotension
This trial will evaluate the effects of a 7-day course of hydrocortisone therapy on short-term morbidity, cardiovascular function, long-term neurodevelopment, and mortality in critically ill, term and late preterm infants…
- Trial name
- NCT01954056
- Testing
- Hydrocortisone
- Where
- 18 sites in United States
- Volunteers
- 12 people
- Sponsor
- NICHD Neonatal Research Network
Arthropathy of Knee, Magnesium Sulfate
Magnesium Sulfate and Neuroendocrine Hormone
Total knee arthroplasty is a procedure that relieves pain in patients with severe symptomatic osteoarthritis, but it can be associated with postoperative pain, which hinders recovery.
- Conditions
- Arthropathy of Knee, Magnesium Sulfate, Cortisol, Dehydroepiandrosterone
- Trial name
- NCT04514731
- Testing
- Magnesium sulfate, Isotonic Saline
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
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