Clinical trials: Cortisol, open to volunteers
Adrenal Insufficiency, Polymyalgia Rheumatica
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency
In this double-blinded randomised placebo-controlled clinical trial, the aim is to determine the effect of supplemental hydrocortisone compared with placebo during mild to moderate physical or mental stress on health related…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica, Giant Cell Arteritis
- Trial name
- RESCUE (NCT05435781)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Marianne Christina Klose
Immediate Implant Placement
Evaluation of Doxycycline Nanoparticle With Gelatin Sponge on Immediate Implant in Esthetic Region
The goal of this clinical trial is to Evaluate the effect of Doxycycline nanoparticles along with gelatin sponge in immediate implant cases in esthetic zone.
- Trial name
- NCT06809829
- Testing
- Immediate Implant Placement
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Kafrelsheikh University
Spine, Low Back Pain
Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain
The goal of this randomized cross-over mechanistic trial is to compare pre- and post-level cortisol and oxytocin changes in patients with chronic spine pain who receive either a hand's on (massage) or a hand's off (talk-based)…
- Conditions
- Spine, Low Back Pain, Neck Pain
- Trial name
- COTHA (NCT06987786)
- Testing
- Massage, Talk-based therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Cushing Syndrome
Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
Multicenter, open-label, non-comparative study to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of osilodrostat in children and adolescent patients with Cushing's syndrome.
- Trial name
- NCT03708900
- Testing
- LCI699
- Where
- 15 sites in United States, Belgium and 5 more
- Volunteers
- 12 people
- Sponsor
- RECORDATI GROUP
Peri-Implantitis
Effect of Customized Versus Stock Healing Abutments on Peri-Implant Soft Tissue
The aim of this study is to compare customized and stock healing abutments for peri-implant soft tissue changes after immediate implant placement in the maxillary esthetic zone, and to assess the feasibility of a full-scale trial.
- Trial name
- NCT07906899
- Testing
- implant placement with a customized healing abutment, implant placement with a prefabricated (stock) healing abutment.
- Volunteers
- 28 people
- Sponsor
- Cairo University
Obesity
Longitudinal Study of the Psychological Impact of Bariatric Surgery
This prospective observational study evaluates the effect of bariatric surgery on mental health and hair cortisol in patients with morbid obesity over a 3-year follow-up.
- Trial name
- BARI-SCL (NCT07780058)
- Where
- 2 sites in Spain
- Volunteers
- 70 people
- Sponsor
- University of Alicante
Mild Autonomous Cortisol Secretion (MACS), Adrenalectomy; Status
Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion
Mild Autonomous Cortisol Secretion (MACS) is a condition in which an adrenal gland produces excess cortisol and is associated with high blood pressure, diabetes, and weight gain.
- Trial name
- NCT07573163
- Testing
- Tirzepatide, Standard medical treatment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Alaa Sada
Sepsis, Septic Shock
Cortisol Levels and Mortality in Septic Shock ICU Patients
This prospective observational study aims to evaluate the prognostic value of cortisol levels and their dynamic changes in critically ill patients with sepsis and septic shock admitted to the intensive care unit.
- Trial name
- NCT07582926
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Ankara Etlik City Hospital
Stress, Anxiety
Psychological and Physiological Effects of Three-Minute Breathing Space Meditation in UPM Postgraduate Students
Postgraduate students often experience psychological distress linked to academic demands, deadlines, research uncertainty, and financial or social pressures, and international students may face additional adjustment challenges.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT07911020
- Testing
- Three-Minute Breathing Space Meditation, Neutral Audio Attention-Control Activity
- Where
- Malaysia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- ZIRUI LIU
Adrenal Insufficiency, Polymyalgia Rheumatica (PMR)
Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment
Cortisol, a glucocorticoid (GC) hormone secreted from the adrenal glands, is essential for survival. Cortisol also possesses anti-inflammatory actions and GC formulations (prednisolone) are used to treat many inflammatory…
- Conditions
- Adrenal Insufficiency, Polymyalgia Rheumatica (PMR), Giant Cell Arteritis (GCA)
- Trial name
- REPLACE (NCT05193396)
- Testing
- Hydrocortisone
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Marianne Andersen
Primary Aldosteronism, Autonomous Cortisol Secretion
68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)
To validate the accuracy of 68Ga-Pentixafor PET/CT and adrenal venous sampling (AVS) in subtype diagnosis of PA/ACS patients with adrenal nodules, based on biochemical and clinical remission outcomes, and to determine whether the…
- Trial name
- NCT06833437
- Testing
- 68Ga-Pentixafor PET/CT, AVS
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Qifu Li
Bariatric Surgery, Virtual Reality
The Effect of Virtual Forest Bathing on Bariatric Surgery Patients
This study will be conducted at the General Surgery Clinic of City Hospital in Erzurum between August 2025 and April 2026 using a randomized controlled experimental design.
- Conditions
- Bariatric Surgery, Virtual Reality, Anxiety
- Trial name
- NCT07152054
- Testing
- virtual forest bathing
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Agoraphobia; Panic, Social Anxiety Disorder
Differential Effects of in Vivo and Virtual Exposure Therapy in Agoraphobia
Anxiety disorders, including agoraphobia, are prevalent in the German population, leading affected individuals to avoid specific places like crowds or public transport.
- Trial name
- VRExpo (NCT06514495)
- Testing
- Therapy
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Diabetes Mellitus, Type 2, Obesity
Type 2 Diabetes, Obesity and Cortisol Excess
The present observational cross-sectional study is aimed to assess: the hidden hypercortisolism (HidHyCo) prevalence in a sample of Type 2 diabetes (T2D) patients and the clinical characteristics more frequently associated with…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Cortisol; Hypersecretion
- Trial name
- DOCOR (NCT05759637)
- Testing
- 1mg DST
- Where
- 5 sites in Italy
- Volunteers
- 3,200 people
- Sponsor
- Istituto Auxologico Italiano
Alcohol Use Disorder, Stress Reaction
Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder
The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder.
- Conditions
- Alcohol Use Disorder, Stress Reaction, Social Stress, Craving
- Trial name
- A03 (NCT06105853)
- Testing
- Trier Social Stress Test, Barlab Cue-Exposure, Functional magnetic resonance imaging
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Pancreas Head Cancer, Pancreas Adenocarcinoma
Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)
The PANENCA trial aims to reduce postoperative complications in patients undergoing pancreatoduodenectomy (also known as a Whipple procedure), a complex surgical operation performed to remove tumors located in or near the head of…
- Conditions
- Pancreas Head Cancer, Pancreas Adenocarcinoma, IPMN, Pancreatic, Cholangio Carcinoma
- Trial name
- PANENCA (NCT07262957)
- Testing
- HOP bundle
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Insomnia
Effects of Connective Tissue Massage in Patients With Chronic Insomnia
This randomized controlled trial will investigate the effects of connective tissue massage on insomnia severity, objective and subjective sleep outcomes, and stress- and autonomic-related biomarkers in adults with chronic…
- Trial name
- NCT07770945
- Testing
- Connective Tissue Massage, Sleep Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Saglik Bilimleri Universitesi
Adrenal Insufficiency
Hydrocortisone Versus Methylprednisolone for the Treatment of Glucocorticoid-Induced Adrenal Insufficiency
This study aims to compare the use of methylprednisolone and hydrocortisone as replacement therapies in patients with glucocorticoid-induced adrenal insufficiency.
- Trial name
- NCT07703098
- Testing
- Patients will receive 3 mg of methylprednisolone once daily. The dose is administered in the morning (1 ½ tablets of 2 mg Medrol after breakfast)., Patients will receive 15 mg of hydrocortisone daily. The dose is split into 10 mg in the morning after breakfast and 5 mg after 6-7 hours.
- Where
- Slovenia
- Volunteers
- 66 people
- Sponsor
- University Medical Centre Ljubljana
Dental Fear and Anxiety
Assessing the Efficacy of Lemongrass and Lavender Aromatherapy in Reducing Dental Anxiety and Pain Associated With Local Anesthetic Injections in Pediatric Dental Patients
The goal of this clinical trial is to evaluate whether aromatherapy using lemongrass or lavender essential oils can reduce dental anxiety and pain perception in children aged 7-11 years undergoing local anesthetic administration…
- Trial name
- NCT07113080
- Testing
- lavender essential oil inhaled using face mask, lemongrass essential oil inhaled using face mask
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hiba Ahmed Eltayeb
Sleep Quality, Well-being
Light in Healthcare Environment (Ljus i sjukhusmiljö)
The goal of this clinical trial is to learn if light can enhance the feeling of well-being and sleep quality in Radiographers. It will also find out if there is an optimal recipe for light.
- Conditions
- Sleep Quality, Well-being, Melatonin, Cortisol
- Trial name
- LIS (NCT06687304)
- Testing
- Light enhancement
- Where
- 3 sites in Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University