Clinical trials: Cortisol Resistance
Systemic Inflammatory Response Syndrome, Hyperglycemia
The Importance of Adrenomedullin (AM) on ACTH-Cortisol-Glucose Axis
Hyperglycemia is frequent manifestations of the human metabolic response to systemic inflammatory response syndrome (SIRS),sepsis and septic shock, and are implicated in the clinical outcome.
- Trial name
- AM (NCT00459511)
- Testing
- Blood AM, IL-6, ACTH, Cortisol, Glucose and Insulin
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Addison Syndrome
Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure
Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.
- Trial name
- NCT00442390
- Testing
- hydrocortisone substitution therapy versus withdrawal
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Obesity
Evaluation of Cortisol and Bile Acids Metabolism in Obese Patients
Bariatric surgery is currently the most efficient treatment for obesity. The sustained weight loss and metabolic improvement seen following Roux-en-Y gastric bypass (RYGB), is explained partly by modifications in hormones…
- Trial name
- CORTABO (NCT04844684)
- Testing
- Blood and urine collection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Obesity, Addison's Disease
The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation
Replacing glucocorticoid in a dose dependent manner (including doses within the physiological range) to subjects with adrenal insufficiency will increase visceral fat accumulation independently of total fat mass.
- Trial name
- NCT00688987
- Testing
- Hydrocortisone, Isocaloric Diet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Insulin Resistance
Hormonal Mechanisms of Sleep Restriction
The purpose of this study is to study the effects of sleep restriction on the production of two hormones, cortisol and testosterone.
- Trial name
- NCT02256865
- Testing
- Ketoconazole, Hydrocortisone, Testosterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Metabolic Syndrome, Premature Aging
The Safety and Efficacy Study of RiaGev in Healthy Adults
This current randomized, double-blind, comparator-controlled, cross over study investigates the efficacy and safety of RiaGev™ via evaluation of NAD+, ATP, glucose, insulin, glutathione, and cortisol levels in healthy adults of…
- Trial name
- NCT04483011
- Testing
- RiaGev
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bioenergy Life Science, Inc.
Polycystic Ovary Syndrome
Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if insulin resistance (how well the body uses insulin and clears sugar) can affect cortisol levels in normal healthy women and women with polycystic ovary syndrome of all body weights.
- Trial name
- NCT00694759
- Testing
- pioglitazone, metformin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Polycystic Ovary Syndrome
Low Dose Growth Hormone in Obese PCOS Women
Study hypothesis: Growth hormone (GH), through its generation of free 'bioavailable' insulin-like growth factor (IGF)-I, can improve insulin sensitivity and the metabolic profile of women with polycystic ovary syndrome.
- Trial name
- NCT00518635
- Testing
- Nutropin
- Where
- United States
- Sponsor
- Oregon Health and Science University
Resistance Training, Sports Nutrition
Effects of Three Carbohydrate Beverages on Resistance Training Performance
This randomized, triple-blinded, counterbalanced crossover trial compared three carbohydrate beverages that provided the same amount of carbohydrate (30 g) but differed in carbohydrate source: dextrose, maltodextrin, and highly…
- Conditions
- Resistance Training, Sports Nutrition, Dietary Carbohydrates
- Trial name
- NCT07874776
- Testing
- Dextrose, Maltodextrin, Highly Branched Cyclic Dextrin
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Adults Growth Hormone Deficiency.
Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency
Hypothesis: Pegvisomant combined with the glucagon stimulation test (GST) can improve the accuracy of this test when used to diagnose adult GH and cortisol (steroid hormone)insufficiency.
- Trial name
- NCT01804413
- Testing
- Pegvisomant, Regular insulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Adrenal Incidentalomas
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas
The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an…
- Trial name
- CHIRACIC (NCT02364089)
- Testing
- Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Glucocorticoid Effect
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
- Trial name
- Gluco-Feed (NCT05167084)
- Testing
- Metyrapone 250 mg Oral Tablets, Hydrocortisone 19,9mg s.c., pulsatile with a flow rate of 10μl/s
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig