Clinical trials: Cost-Effectiveness
Cervical Cancer Screening
Single Visit Clinical Validation of ScreenFire, a Low-Cost HPV Test: Efficacy and Cost Effectiveness (Phase 2)
In high-income countries, prevention strategies have led to declines in cervical cancer rates by more than 75% in high-income countries.
- Trial name
- SCALE AIM 2 (NCT07538050)
- Testing
- Same day screen and treat
- Where
- El Salvador
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Delivery Uterine
Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2
For about 10% of pregnancies, it is necessary to induce delivery for medical reasons. Prostaglandins alone can be used to perform cervical ripening in cases of immature cervix.
- Trial name
- CYTOPRO (NCT01765881)
- Testing
- Misoprostol, Dinoprostone
- Where
- 4 sites in France
- Volunteers
- 1,700 people
- Sponsor
- University Hospital, Toulouse
Cardio-vascular Disease, Depression Disorders
Supporting Patients Starting New Medicines: Evaluating the myCare Start Service in Switzerland
In Phase B, the aim is to evaluate the myCare Start service in routine care within the ambulatory primary care medicine and community pharmacy setting in Switzerland.
- Conditions
- Cardio-vascular Disease, Depression Disorders, Diabetes, COPD
- Trial name
- myCare Start-I (NCT07036471)
- Testing
- myCare Start
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- University of Geneva, Switzerland
Depressive Symptoms, Quality of Life
Non-pharmacological Care for Depression in Cancer Patients Using VR and TMS
Despite its significant impact on individuals and healthcare systems, substantial gaps remain in the clinical and rehabilitative management of depression in oncology patients.
- Conditions
- Depressive Symptoms, Quality of Life, Cognitive Impairment
- Trial name
- INCEPT (NCT06589544)
- Testing
- Virtual Reality-based Cognitive Remediation (VR-COG) + Treatment as Usual (TAU), Repetitive transcranial magnetic stimulation (rTMS) + Treatment as usual (TAU), Treatment as Usual (TAU)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University Hospital of Ferrara
Obesity, Bariatric Surgery
Effectiveness of a Modified Cost-Effective Dietary Plan in Promoting Weight Loss and Preservation of Lean Body Mass in Patients After Bariatric Surgery
This study will see if a low-cost dietary plan, based on the standard dietary guidelines of the American Society for Metabolic and Bariatric Surgery (ASMBS) and using locally available foods, can help patients lose weight and…
- Conditions
- Obesity, Bariatric Surgery, Nutritional Status, Body Composition
- Trial name
- NCT07111767
- Testing
- Low-Cost Post-Bariatric Diet, Standard High-cost Post-Bariatric Diet
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- Khyber Teaching Hospital
Metastatic Renal Cell Carcinoma
Cost Effectiveness Of Sunitinib In Central America And Caribbean
Primary Hypothesis: The therapy with Sunitinib represents better cost-effectiveness than IFN-α in first-line treatment for metastatic Renal Cell Carcinoma (mRCC) in Central America and Caribbean countries
- Trial name
- NCT01033981
- Testing
- Sunitinib
- Where
- Panama
- Volunteers
- 4 people
- Sponsor
- Pfizer
Oncology
Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging
The aims of this study are to evaluate the image quality and robustness of a whole-body MRI protocol by using an innovative partially automatic algorithm (DOT engine), that automatically optimizes protocol parameters depending on…
- Trial name
- NCT03648619
- Testing
- Semi whole-body MRI
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Kantonsspital Baden
Diabetes Mellitus, Surgery
Developing and Testing an Implementation Strategy to Improve Perioperative Diabetes Care
Optimising glycaemic control during hospital stay reduces the rate of infections, length of stay and mortality, in particular in surgical patients.
- Trial name
- NCT01610674
- Testing
- Tailored improvement strategy
- Where
- Netherlands
- Volunteers
- 811 people
- Sponsor
- Radboud University Medical Center
Osteoarthritis
Knee Injection RCT
Hypothesis: Ketorolac injection is a cost-effective adjunct in the nonoperative treatment of knee osteoarthritis (OA) compared to steroids and viscosupplementation.
- Trial name
- NCT03694821
- Testing
- Ketorolac Tromethamine Injection, Methylprednisolone Acetate Injection, Hylan G-F 20
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- UConn Health
Anemia, Neoplasms
Cost-effectiveness Study of Epoetin Alfa and Darbepoetin Alfa in Adult Patients With Cancer Who Have Anemia
The purpose of this study is to evaluate the cost-effectiveness of epoetin alfa compared with darbepoetin alfa in the treatment of anemia in adults receiving chemotherapy for cancer.
- Trial name
- NCT00264108
- Testing
- Darbepoetin alfa, Epoetin alfa
- Where
- 20 sites in Netherlands
- Volunteers
- 492 people
- Sponsor
- Janssen-Cilag B.V.
Heart Failure, Diabetes
Dapagliflozin at Discharge on Hospital Heart Failure Readmission
This study will evaluate the safety and efficacy of dapagliflozin treatment in preventing hospital re-admissions, emergency room (ER) visits, urgent clinic visits, and death in patients with and without type 2 diabetes (T2D)…
- Trial name
- NCT04249778
- Testing
- Dapagliflozin
- Where
- 3 sites in United States
- Volunteers
- 105 people
- Sponsor
- Emory University
Heart Failure, Stroke
BeyondSilos - More Personalised and Coordinated Care and Improved Outcomes for Elderly Patients
The study evaluates the impact of the new organisational models developed in the framework of the BeyondSilos pilot service in order to provide ICT supported integrated health and social care to elderly patients
- Conditions
- Heart Failure, Stroke, COPD, Diabetes
- Trial name
- BeyondSilos (NCT03111004)
- Testing
- New Care
- Volunteers
- 1,840 people
- Sponsor
- Him SA
Chronic Neck Pain
Comparative Effectiveness and Cost-effectiveness of Chuna Manual Therapy for Chronic Neck Pain
A multi-center randomized controlled trial assessing the comparative effectiveness and cost-effectiveness of Chuna manual therapy for chronic neck pain
- Trial name
- NCT03294785
- Testing
- Chuna manual therapy, Conventional medication, Physical therapy
- Where
- 5 sites in South Korea
- Volunteers
- 108 people
- Sponsor
- Jaseng Medical Foundation
Asthma
Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care
ANCHOR is a prospective, phase IV, interventional, single-arm, open-label study of 1,500 adult participants with symptomatic asthma requiring the use of rescue therapy aimed to compare the asthma exacerbation rates before and…
- Trial name
- ANCHOR (NCT06422689)
- Testing
- Albuterol and budesonide inhalation aerosol
- Where
- 11 sites in United States
- Volunteers
- 1,511 people
- Sponsor
- AstraZeneca
Tick Borne Encephalitis (TBE)
Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic
This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic.
- Trial name
- ENCZECH (NCT07274046)
- Testing
- No intervention
- Where
- 4 sites in Czechia
- Volunteers
- 209 people
- Sponsor
- Charles University, Czech Republic
End Stage Renal Disease
Cost Utility Analysis of HD and CAPD in Ministry of Health Dialysis Centres, Malaysia
End-stage renal disease represents a major problem for public health, and is a severe disease affecting hundreds of millions of people in the world and increasing rapidly.
- Trial name
- NCT02862717
- Where
- 5 sites in Malaysia
- Volunteers
- 173 people
- Sponsor
- National University of Malaysia
Sexually Transmitted Infection, HIV
Repeat Sexually Transmitted Infection (STI) Patients: Tailored Socio-Contextual Intervention to Reduce HIV Risk
People who present repeatedly at Sexually Transmitted Infection (STI) clinics represent a key population for HIV prevention intervention research.
- Trial name
- NCT01510262
- Testing
- Tailored Socio-Contextual Intervention, Standard of Care
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Wisconsin, Milwaukee
Challenging Behaviour
Clinical and Cost Effectiveness of Positive Behaviour Support: a Trial
Many people with intellectual disability have challenging behaviour which often has serious consequences such as the prescription of long term medication, in-patient admissions and disruption of normal daily activities.
- Trial name
- PBS (NCT01680276)
- Testing
- PBS based staff training, Treatment as Usual
- Where
- 3 sites in United Kingdom
- Volunteers
- 246 people
- Sponsor
- University College, London
Parkinson Disease
Multicenter Implementation of E-monitoring in Parkinson's Disease
Introduction and rationale: Parkinson´s disease (PD) is a slowly progressive and chronic disease, characterized by a range of motor and non-motor symptoms such as bradykinesia, tremor and falls, but also sleep disturbance…
- Trial name
- EPD (NCT05164783)
- Testing
- Sanacoach Parkinson (SCP)
- Where
- 6 sites in Netherlands
- Volunteers
- 258 people
- Sponsor
- Zuyderland Medisch Centrum
Suicide, Attempted
Study About Treatment After a Suicide Attempt
Effective, brief, low-cost interventions for individuals who attempt suicide are needed to save lives and achieve the goals of the National Strategy for Suicide Prevention.
- Trial name
- NCT03894462
- Testing
- Attempted Suicide Short Intervention Program, Zero Suicide Usual Care
- Where
- 3 sites in United States
- Volunteers
- 443 people
- Sponsor
- University of Rochester
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