Clinical trials: Cost-Effectiveness
Coronary Artery Disease, Diagnosis
Evaluating AI-Gatekeeper Software in Coronary Artery Stenosis Screening: A Multicenter RCT
The purpose of this study is to determine the efficacy, safety, and cost-effectiveness of AI-Gatekeeper software to assist clinicians in the diagnosis of coronary artery disease by predicting coronary artery stenosis (≥50%) from…
- Trial name
- AIGatekeeper (NCT06178900)
- Testing
- Assisted by the AI-Gatekeeper software group
- Where
- 5 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- INFINITT Healthcare
Adhesive Capsulitis
Comparison of Digital and Conventional Physical Therapy on Cost Effectiveness, Pain, and Disability in Adhesive Capsulitis
Adhesive capsulitis is a common musculoskeletal condition characterized by shoulder pain, progressive stiffness, and functional limitation, significantly affecting activities of daily living and quality of life.
- Trial name
- NCT07482111
- Testing
- Digital Physical Therapy (Tele-rehabilitation Program), Conventional Physiotherapy Rehabilitation Program
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Lahore
Cardio-vascular Disease, Depression Disorders
Supporting Patients Starting New Medicines: Evaluating the myCare Start Service in Switzerland
In Phase B, the aim is to evaluate the myCare Start service in routine care within the ambulatory primary care medicine and community pharmacy setting in Switzerland.
- Conditions
- Cardio-vascular Disease, Depression Disorders, Diabetes, COPD
- Trial name
- myCare Start-I (NCT07036471)
- Testing
- myCare Start
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- University of Geneva, Switzerland
Low Back Pain
The Costs and Effectiveness of Cognitive Functional Therapy for People with Persistent Low Back Pain in Coventry.
Previous studies have shown Cognitive Functional Therapy (CFT) results in sustained clinically important improvements compared to a variety of interventions for persistent low back pain (LBP).
- Trial name
- NCT06161753
- Testing
- Cognitive Functional Therapy
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Esthetic Zone, Single Tooth Lost
Cost Effectiveness of Various Implant Placement Protocols in the Esthetic Zone
Loss of teeth in the anterior upper jaw significantly affects both well-being and chewing function. Nowadays, dental implants are the treatment of choice for replacing missing teeth with fixed dental prostheses and are often…
- Conditions
- Esthetic Zone, Single Tooth Lost, Accuracy of Dental Implants, Dimensional Changes
- Trial name
- NCT05940662
- Testing
- Immediate Implant Placement, Early Implant Placement, Late Implant Placement
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University of Bern
Tuberculosis Diagnosis, HIV
Optimizing Clinical Outcomes in HIV-Infected Adults & Children
This is a study to evaluate Xpert MTB/RIF as the first-line TB diagnostic test in HIV-infected adults and pediatric patients as a means to obtain faster, more accurate TB diagnosis.
- Trial name
- NCT02043080
- Testing
- Xpert MTB/RIF Tuberculosis diagnostic tool
- Where
- Zambia
- Volunteers
- 1,436 people
- Sponsor
- University of North Carolina, Chapel Hill
Intermittent Claudication
(Cost) Effectiveness Study of Exercise Therapy in Patients With Peripheral Arterial Disease
The purpose of this study is to determine if supervised exercise therapy in a physiotherapeutic setting, with or without therapy feedback, is more (cost-)effective than exercise therapy based on a 'go home and walk' advice…
- Trial name
- EXITPAD (NCT00279994)
- Testing
- Exercise therapy, Accelerometer (PAM; Personal Activity Monitor), Oral Exercise Therapy advise
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Atrium Medical Center
Major Depressive Disorder
e-Compared-S: Comparative Effectiveness Research on Internet-based Depression Treatment - Spanish Trial
To compare the clinical and cost-effectiveness of blended Cognitive Behavioural Therapy (CBT) for adults with major depressive disorder (MDD) with treatment as usual (TAU) in Spanish population.
- Trial name
- E-COMPARED_S (NCT02361684)
- Testing
- Blended CBT treatment, Treatment as usual
- Where
- 2 sites in Spain
- Volunteers
- 160 people
- Sponsor
- Universitat Jaume I
Asthma
REALL: A Retrospective Observational Study to Compare the Effectiveness and Cost-Effectiveness Between Different Step-3 Asthma Treatment Strategies
This is a retrospective observational study utilising anonymised individual patient clinical and prescribing information routinely collected by UK General Practitioners (GPs).
- Trial name
- REALL (NCT00628563)
- Where
- United Kingdom
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Emotional Disorder, Anxiety Disorders
UP in Blended Format for Transdiagnostic Treatment of Emotional Disorders in the Spanish National Health System
The present randomized, controlled trial will compare the efficacy, cost-effectiveness, and implementation characteristics of a blended intervention based on the Unified Protocol (UP) for transdiagnostic treatment of emotional…
- Conditions
- Emotional Disorder, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT04304911
- Testing
- Blended intervention (UP-APP), Cognitive Behavioral Therapy (TAU)
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Cleft Lip and Palate
Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate
The purpose of this trial is to evaluate if the use of Bone Morphogenic Protein(BMP)/Demineralized Bone Matrix (DBM) versus the use of autologous Iliac Crest Bone Graft (ICBG) will result in an increase in total cost…
- Trial name
- NCT04234971
- Testing
- Intervention group (DBM/BMP), Control group(autologous ICBG)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center, Houston
Dementia
Effectiveness and Cost-effectiveness of vCST and Online Dementia Carer Support
A multicentre single-blind cluster randomised trial to evaluate the effectiveness and cost-effectiveness of virtually delivered versus in-person cognitive stimulation therapy (CST) and carer support in people living with dementia…
- Trial name
- NCT05783414
- Testing
- f2f CST, f2f carer support, vCST
- Where
- Hong Kong
- Volunteers
- 156 people
- Sponsor
- The University of Hong Kong
HIV Infections
Implementation a Data-to-Care Strategy to Improve HIV Continuum Outcomes for Out of Care People Living With HIV (PLWH) in Ukraine
The goal of this clinical trial is to study the preliminary effectiveness of a data to care intervention versus standard of care for people living with HIV in Ukraine.
- Trial name
- NCT05821413
- Testing
- Data to care, Standard of Care
- Where
- Ukraine
- Volunteers
- 160 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Insomnia
Stepped Care Model for the Wider Dissemination of Cognitive-Behavioural Therapy for Insomnia Among Cancer Patients
Insomnia is very common in cancer patients. When left untreated, insomnia can lead to numerous serious consequences (e.g., psychological disorders) for the individual and significant costs for society (e.g., increased medical…
- Trial name
- Stepped Care (NCT01864720)
- Testing
- Professionally-administered cognitive-behavioral therapy for insomnia (CBT-I), Web-based cognitive-behavioral therapy for insomnia (CBT-I)
- Where
- Canada
- Volunteers
- 177 people
- Sponsor
- CHU de Quebec-Universite Laval
UTERINE CERVICAL NEOPLASMS, ENDOMETRIAL NEOPLASMS
Cost-Effectiveness and Patients Satisfaction of Conventional vs Robotic-Assisted Laparoscopy in Gynecologic Oncologic Indications
Laparoscopic surgery is gaining currency in the field of oncologic care, particularly for colorectal and gynecologic cancers. This innovation could be used either for staging purpose and therefore could steer global therapeutic…
- Trial name
- NCT02865889
- Testing
- Laparoscopy in Gynecologic Oncologic Indications, Conventional surgery (abdominal radical surgery)
- Where
- France
- Volunteers
- 343 people
- Sponsor
- Institut Paoli-Calmettes
Head and Neck Cancer, Pain
Pain: Screen and Treat
This study is looking at treating cancer pain in head and neck cancer. Patients are asked in outpatients to score their worst pain on a scale of 0 to 10 in the last 24 hours.
- Trial name
- NCT01716780
- Testing
- Intervention
- Where
- United Kingdom
- Volunteers
- 156 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Chronic Low-back Pain
Virtual Reality Integrated Within Physiotherapy for Patients With Complex Chronic Low Back Pain
This study examines the effect of a 12-week intervention of physiotherapy with integrated Virtual Reality (VR) on 120 patients with complex chronic low back pain.
- Trial name
- VARIETY (NCT05701891)
- Testing
- Physiotherapy with integrated Virtual Reality, Physiotherapy (usual care)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- HAN University of Applied Sciences
Inflammatory Bowel Diseases, Crohn Disease
Cost-effectiveness of TPMT Pharmacogenetics
The purpose of this study is to determine whether thiopurine S-methyltransferase (TPMT) genotyping prior to thiopurine use is cost-effective in patients with inflammatory bowel disease (IBD) in need of immune suppression.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- TOPIC (NCT00521950)
- Testing
- TPMT genotyping; Drug: azathioprine or 6-mercaptopurine, azathioprine (AZA) or 6-mercaptopurine (6-MP)
- Where
- 3 sites in Netherlands
- Volunteers
- 853 people
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Barrett's Esophagus, Esophageal Adenocarcinoma
A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer
This study serves, in part, to prepare for a future large cohort study. The goal of the study is: 1. The collection of various tissue samples (blood, biopsies and "esophageal brushes") and their analysis. 2.
- Trial name
- Endeavor-1 (NCT06523374)
- Testing
- Endoscopic brush cytology
- Where
- 9 sites in Belgium, Denmark and 4 more
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Parkinson Disease
Cost-effectiveness of Nursing Interventions for Patients With PD
Background: Current guidelines recommend that every person with Parkinson's disease (PD) should have access to Parkinson's Disease Nurse Specialist (PDNS) care.
- Trial name
- NICE-PD (NCT03830190)
- Testing
- Parkinson's disease nurse specialist care
- Where
- Netherlands
- Volunteers
- 242 people
- Sponsor
- Radboud University Medical Center
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