Clinical trials: Cost-Effectiveness
Older Adults
Self-administered Dual-task Training for Reducing Falls Among the Older Adults
Evidence supports that dual-task training reduces fall risk among older adults. However, the current framework for preventive care for fall prevention in Hong Kong does not include formal cognitive training, while little to no…
- Trial name
- sDTT (NCT05533333)
- Testing
- Falls prevention exercises
- Where
- Hong Kong
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Neurodegenerative Diseases, Memory Disturbances
Health Technology Assessment of Diagnostic Approaches in Alzheimer's Disease
Background: New research criteria for the diagnosis of Alzheimer's disease (AD) have recently been developed to enable an early diagnosis of AD pathophysiology by relying on emerging biomarkers.
- Trial name
- NCT01450891
- Where
- 4 sites in Netherlands
- Volunteers
- 304 people
- Sponsor
- Maastricht University Medical Center
Dental Caries
Effectiveness of ART and Conventional Treatment - Practice-based Clinical Trial
Background: Dental caries is still a public health problem among Brazilian children and doubts still exist regarding the most effective restorative technique.
- Trial name
- NCT02568917
- Testing
- Atraumatic Restorative Treatment - Ketac Molar Easy Mix, Conventional Restoration - Composite Resin (Bulk Fill)
- Where
- Brazil
- Volunteers
- 800 people
- Sponsor
- University of Sao Paulo
Emotional Disorders, Depression Anxiety Disorder
Cost-effectiveness and Implementation of a Transdiagnostic Internet-based Intervention for Emotional Disorders in Community Care.
Emotional disorders (ED) are one of the leading causes of disability. They are highly prevalent and have an impact on quality of life.
- Conditions
- Emotional Disorders, Depression Anxiety Disorder, Depression Disorders, Anxiety Disorders
- Trial name
- TREAT-ED (NCT07345117)
- Testing
- Internet-based psychological intervention, Treatment as usual (TAU)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Universitat Jaume I
Malaria, Falciparum
Preventing Malaria During Pregnancy in Epidemic-prone Areas.
The purpose of this study is to compare the efficacy and cost-effectiveness of three alternative strategies for the prevention of malaria during pregnancy in an epidemic-prone area of low transmission in the East African…
- Trial name
- NCT00142207
- Testing
- Intermittent preventive treatment:sulphadoxine-pyrimethamine, Insecticide-treated mosquito bed net
- Where
- Uganda
- Volunteers
- 4,775 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Low Back Pain
FAcet-joint Injection Clinical and Cost-effective Trial
Lumbar facet-joints are small, paired joints in the low back that provide stability, integrity and flexibility of movement to the spine.
- Trial name
- FACET (NCT03339362)
- Testing
- Active Procedure
- Where
- 3 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- Barts & The London NHS Trust
First CarpoMetacarpal Osteoartrithis, Basal Thumb Osteoartrithis
Clinical Trial to Estimate the Efficacy of the Trapezium-Metacarpal (TMC) Prosthesis Compared to Suspensionplasty.
The main objective of the study is to evaluate the efficacy, safety and cost-utility of the Trapezium-Metacarpal (TMC) prosthesis against Suspensionplasty with Abductor Pollicis Longus (APL) for the treatment of patients with…
- Trial name
- NCT04562753
- Testing
- Maïa® TMC Prosthesis (Lépine Groupe), APL Suspensionplasty
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Drug Use, Hepatitis
Low Dead-space Injecting Equipment Distribution Program for People Who Inject Drugs in Low- and Middle-income Countries
Implementation and evaluation of a distribution program for low dead-space syringes/needles (LDSS/N) in Armenia, Georgia, and Tanzania, Egypt, Nigeria, Vietnam, India, Ukraine, and South Africa.
- Conditions
- Drug Use, Hepatitis, Hiv
- Trial name
- NCT06395129
- Testing
- Low dead-space syringes/needles, Hepatitis C Antibody Rapid Diagnostic Test, HIV rapid Diagnostic Test
- Where
- 9 sites in Armenia, Georgia and 1 more
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Médecins du Monde
Self Harm
Multicenter Study to Evaluate the Clinical and Cost Effectiveness of a Youth Culturally Adapted Therapy (YCMAP)
To evaluate the clinical and cost-effectiveness of a youth culturally adapted manual assisted therapy (YCMAP) in Pakistani Adolescents with a history of self-harm
- Trial name
- NCT04131179
- Testing
- Youth Culturally Adapted Manual Assisted Psychological Therapy (Y-CMAP)
- Where
- 3 sites in Pakistan
- Volunteers
- 684 people
- Sponsor
- Pakistan Institute of Living and Learning
Trisomy 21
Down Syndrome Screening Based on Dried Blood Spots and Cell-free Fetal DNA
There are 26,600 Down Syndrome newborns every year in China. The economic burden of this disease is 65,000 USD for lifetime of every patient.
- Trial name
- DBS&CFF (NCT01837979)
- Testing
- cell-free fetal DNA
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hepatitis C, RDT
Simplifying Hepatitis C Pathways for People Who Inject Drugs in Armenia, Georgia, and Tanzania
The goal of this non-randomised, quasi-experimental, prospective comparative trial is to trial simplified care pathways for hepatitis C testing and treatment for people who inject drugs in Armenia, Georgia, and Tanzania.
- Trial name
- CUTTS HepC (NCT06159504)
- Testing
- sofosbuvir/velpatasvir (SOF/VEL), Shortened read time of rapid diagnostic test for hepatitis C virus.
- Where
- Armenia
- Volunteers
- 3,040 people
- Sponsor
- Médecins du Monde
Lumbar Disc Prolapse With Radiculopathy
Safety Study of ARO Spinal System as an Adjunct to Lumbar Decompression
To evaluate the clinical safety and effectiveness of the ARO Spinal System and to assess preliminary cost/benefit analysis in patients undergoing decompression surgery for symptomatic lumbar disc herniations.
- Trial name
- NCT01970514
- Testing
- ARO Spinal System
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- ARO Medical
Hand Injuries and Disorders, Neurological Conditions
3D Hand Orthosis Trial
In people with chronic hand conditions, hand orthoses are frequently prescribed to improve performance in activities of daily living (ADL).
- Conditions
- Hand Injuries and Disorders, Neurological Conditions, Neuromuscular Diseases (NMD), Musculoskeletal Conditions (e.g., Tendinitis, Capsulitis)
- Trial name
- NCT07633821
- Testing
- 3D-printed hand orthosis (intervention), Conventional hand orthosis (control)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Emotional Disorders, Depressive Disorder
The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders
The goal of this clinical trial is to evaluate the effectiveness and cost-effectiveness of a digital mindfulness-based intervention in adults (aged 18-65) diagnosed with emotional disorders like depression or anxiety.
- Conditions
- Emotional Disorders, Depressive Disorder, Anxiety Disorders, Obsessive-Compulsive Disorder
- Trial name
- NCT07458100
- Testing
- Mindfulness Intervention for Emotional Distress
- Where
- China
- Volunteers
- 464 people
- Sponsor
- Peking University
Endoscopic Submucosal Dissection, Early Gastric Cancer
Efficacy and Safety Study of Endoscopic Submucosal Dissection for Early Gastric Cancer
The purpose of this study is to evaluate the safety and clinical effectiveness of ESD(Endoscopic Submucosal Dissection) for early gastric cancer analyzing short-term and long-term results of endoscopic treatment.
- Conditions
- Endoscopic Submucosal Dissection, Early Gastric Cancer, Multi-center, Single-arm Clinical Trial, Historical Control Group
- Trial name
- ESD (NCT01132469)
- Testing
- Endoscopic Submucosal Dissection
- Where
- South Korea
- Volunteers
- 1,158 people
- Sponsor
- National Evidence-Based Healthcare Collaborating Agency
Major Depressive Disorder
Efficacy and Cost-effectiveness of Internet-delivered CBT for Adolescents With Depression
Adolescent depression is a prevalent and impairing condition that can be effectively treated with Cognitive Behavior Therapy (CBT). However, a majority of adolescents do not have access to CBT.
- Trial name
- IDA (NCT04977856)
- Testing
- Behavioral activation (BA), Regular care within primary or secondary mental health care for children
- Where
- Sweden
- Volunteers
- 219 people
- Sponsor
- Region Stockholm
Musculoskeletal Disorders, Emergency Care
Effect and Cost of a Physiotherapy-led Care Model in Emergency Departments for Patients With Minor Musculoskeletal Injuries
Both in Denmark and internationally, emergency departments have been overwhelmed for several years by a growing number of patients, combined with a shortage of doctors and nurses.
- Conditions
- Musculoskeletal Disorders, Emergency Care, Physiotherapy
- Trial name
- NCT07137754
- Testing
- Advanced practice physiotherapy, Usual Care
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- Aarhus University Hospital
Clinical Indication for First Metatarsal Joint Arthrodesis
TMT Fusion Plate vs. Two Crossed Screws
This study will compare TMT Fusion Plate versus two crossed screws for the fixation of first tarsometatarsal joint arthrodesis. Patients who meet eligibility criteria will be randomly assigned to one of these two treatment…
- Trial name
- TMT (NCT02096146)
- Testing
- TMT Fusion plate, Two crossed screws
- Where
- 5 sites in United States, Colombia and 1 more
- Volunteers
- 12 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Hemorrhoids
Local Anaesthetic Day-care Haemorrhoidectomy Challenges Traditional Concepts - a Randomised Controlled Trial
Background: Local anaesthetic day-care open haemorrhoidectomy (LH) is feasible, cheap and may be the cost-effective surgical approach to third degree haemorrhoids.
- Trial name
- NCT00503269
- Testing
- Hemorrhoidectomy
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Stroke
Effectiveness of Self-monitoring and Treatment of Blood Pressure Following Stroke or Transient Ischaemic Attack
This blinded end point RCT will recruit high risk TIA and mild stroke patients (through the emergency TIA clinics and the acute stroke services at the Norfolk \& Norwich University Hospital) who require anti-hypertensive therapy…
- Trial name
- TEST-BP (NCT02947490)
- Testing
- Self BP measurement, Standard Care, Standard BP management
- Where
- United Kingdom
- Volunteers
- 165 people
- Sponsor
- University of East Anglia
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