Clinical trials: Cost-Effectiveness
Diagnosis, Asthma
Fractional Exhaled Nitric Oxide (FeNO)- Test as add-on Test in the Diagnostic Work-up of Asthma
The Global Initiative of Asthma Guideline (GINA) recommends a flowchart to diagnose asthma with first-step spirometry with reversibility and a bronchial challenge test (BPT) with histamine or methacholine as a second step.
- Trial name
- INFERNO (NCT06230458)
- Testing
- FeNO-test
- Where
- Netherlands
- Volunteers
- 171 people
- Sponsor
- Franciscus Gasthuis & Vlietland (Hospital)
Neurasthenia, Chronic Pain
Effectiveness of Mind-Body Interventions for Frequent Attendees Suffering From Medically Unexplained Symptoms (MUS)
The purpose of this study is to check the medical efficacy and economic benefits of multidisciplinary care in patients with unexplained medical complaints and consume medical services frequently.
- Conditions
- Neurasthenia, Chronic Pain, Chronic Headache
- Trial name
- NCT02141568
- Testing
- Medical and Psychological treatment
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Soroka University Medical Center
Emotional Disorder
Cost-effectiveness of a Transdiagnostic Psychological Treatment for Emotional Disorders in Primary Care
The aim of this study is to test the cost-effectiveness and cost-utility of adding a transdiagnostic group cognitive-behavioural therapy (TD-CBT) to treatment as usual (TAU) for emotional disorders in primary care .
- Trial name
- PsicAP-Costs2 (NCT05314920)
- Testing
- Transdiagnostic cognitive-behavioral therapy (TD-CBT), Bernstein and Borkovec progressive muscle relaxation (PMR)
- Where
- 4 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
HIV
Optimal Intervention to Full Viral Suppression: Text Me, Alexis!
Text Me, Alexis! is a three-arm randomized controlled trial (RCT) to determine the optimal and most cost-effective intervention for advancing trans women living with HIV to full viral suppression.
- Trial name
- NCT06408350
- Testing
- Text Me, Alexis!
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Friends Research Institute, Inc.
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
PTSD - Post Traumatic Stress Disorder
First-Line Intervention for PTSD - Intensive Treatment
The goal of this clinical trial is to learn if an intensive program can treat post-traumatic stress disorder (PTSD) in adults getting treatment for the first time, and whether it has lower societal costs.
- Trial name
- FLIP-IT (NCT06700590)
- Testing
- Intensive Treatment, Treatment as usual
- Where
- 4 sites in Netherlands
- Volunteers
- 186 people
- Sponsor
- ARQ National Psychotrauma Centre
Peripheral Artery Disease (PAD)
Use of Three-Dimensional Printed Models for Endovascular Planning and Follow-up in Patients Affected by Aorto-Iliac-Femoral-Popliteal Arterial Disease Undergoing Balloon Angioplasty. A Single-center, Single-blind Randomized Controlled Trial
Lower extremity peripheral arterial disease is a major health problem. Currently, balloon angioplasty represents the most commonly performed treatment for patients affected by vascular claudication or critical limb ischemia.
- Trial name
- 3DPAD-1 (NCT07000097)
- Testing
- PTA planning supported by 3D-printed model, PTA (Standard of Care)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Obesity
Evaluation of an Enhanced Delivery Model for Go NAPSACC
This study will compare the effectiveness and cost of Basic and Enhanced delivery models for Go NAPSACC on child care centers' use of evidence-based nutrition and physical activity practices.
- Trial name
- NCT03938103
- Testing
- Enhanced Go NAPSACC, Basic Go NAPSACC
- Where
- 2 sites in United States
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiomyopathies
Contrast Echocardiography Cost Effectiveness for Left Ventricular Thrombus Assessment
To perform a cost-effectiveness analysis for the routine use of contrast in rest echocardiography in patients with dilated or ischemic cardiomyopathy from the United States healthcare system, provider and payer perspectives.
- Trial name
- NCT02555527
- Where
- United States
- Volunteers
- 500,000 people
- Sponsor
- Duke University
Low Back Pain
Comparative Effectiveness Study for Surgery vs. Non-Surgery in Patients With Low Back Pain
Purpose: Comparative effectiveness research (CER) between surgical and non-surgical treatment for patients with low back pain Hypothesis: There will be significant differences in surgical and non-surgical treatment effect in…
- Trial name
- CES_SNS_LBP (NCT02883569)
- Testing
- open or endoscopic discectomy, epidural block, exercise
- Where
- South Korea
- Volunteers
- 1,102 people
- Sponsor
- Seoul National University Hospital
Prolapse; Female
Cost-effectiveness Comparison Between Vaginal Versus Robotic Mesh Surgery for Apical Prolapse: Prospective, Cohort Study
Cost-effectiveness, safety, outcomes and diagnostic development in advanced apical female genital prolapse reconstructive surgery by vaginal and robotic-assisted mesh surgery.
- Trial name
- KIDS (NCT03878056)
- Testing
- Vaginal: UpholdTM Lite Vaginal Support - Boston Scientific
- Where
- Sweden
- Volunteers
- 147 people
- Sponsor
- Karolinska Institutet
Low Back Pain
Cost of Long Term Disability in Patients With Chronic Non-Specific Low Back Pain
The purpose of the study was to determine the cost-effectiveness of a function-centred treatment (FCT) compared with a pain-centred treatment (PCT) in patients with chronic low back pain (LBP) in an in-patient setting.
- Trial name
- NCT00652236
- Testing
- Physiotherapy
- Where
- Switzerland
- Volunteers
- 174 people
- Sponsor
- Klinik Valens
Mental Health, Psychiatric Problems
Relationships in Good Hands - Clinical and Cost-effectiveness of Dyadic Developmental Psychotherapy
The research question is: Can the research recommend better ways for social care and health services to work work together to help adoptive and foster families? Can a therapy called DDP improve the mental health of 5-12 year old…
- Conditions
- Mental Health, Psychiatric Problems, Child Neglect, Maltreatment
- Trial name
- RIGHT (NCT04187911)
- Testing
- Dyadic Developmental Psychotherapy (DDP), Services as Usual (SAU)
- Where
- 16 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- University of Glasgow
Hepatitis C
Safety and Efficacy of Decentralized HCV Treatment vs Standard-of-Care in Rio de Janeiro (Brazil)
Up to 650,000 people in Brazil are living with chronic hepatitis c virus (HCV) infection. Hepatitis C is a silent disease, and up to 20% of cases can progress to liver cirrhosis and its complications.
- Trial name
- HCVPCL05/20 (NCT06306300)
- Testing
- Specialist - Epclusa 400Mg-100Mg Tablet, Non- specialist - Epclusa 400Mg-100Mg Tablet, HCV Self-Testing kit (Ora-Quick HCV ST or Wond-Foo HCV ST)
- Where
- 2 sites in Brazil
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Depressive Disorder, Treatment-Resistant
Lithium Versus Quetiapine in Treatment Resistant Depression
LQD is a multicentre randomised clinical trial comparing the clinical and cost effectiveness of lithium versus quetiapine when used as add-on therapies to antidepressant medication for patients with treatment resistant…
- Trial name
- LQD (NCT03004521)
- Testing
- Quetiapine, Lithium
- Where
- United Kingdom
- Volunteers
- 276 people
- Sponsor
- King's College London
Stroke, Cerebrovascular Disorders
Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation
The purpose of this study is to investigate whether aerobic exercise improves the participant's ability to recover function in the arm and leg affected by the participant's stroke.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT03819764
- Testing
- Aerobic Exercise, Upper Extremity Repetitive Task Practice
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Myocardial Ischemia, Myocardial Injury
Perioperative Myocardial Ischemia: Troponin Monitoring,Cost-effectiveness, Insights Into Pathophysiology
Background: Despite preoperative screening, technical improvements and increased patient monitoring, perioperative myocardial infarction (PMI) remains the first cause of morbidity and mortality within 30 days after surgery.
- Conditions
- Myocardial Ischemia, Myocardial Injury, Morality
- Trial name
- PMI (NCT03438448)
- Testing
- High sensitive Troponin T monitoring
- Where
- Spain
- Volunteers
- 1,510 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Thoracoabdominal Aortic Aneurysm
Safety, Efficacy, Longitudinal Costs and Patient-Centered Outcomes Using a TAAA Debranching Device
The primary purpose of this study is to assess the use of the TAAA Debranching Stent Graft System to repair thoracoabdominal aortic aneurysms in patients having appropriate anatomy, as measured by device safety, effectiveness…
- Trial name
- NCT03637374
- Testing
- Visceral Manifold and Thoracic Bifurcation, Unitary Manifold, TAAA Debranching Stent Graft System
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Chest Pain, Acute Coronary Syndrome
Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
This multi-center, randomized, controlled trial conducted in Emergency Departments (ED) compares computed tomography (CT) coronary angiography with the traditional approach (usual care) for low- to intermediate-risk chest pain…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT00933400
- Testing
- CT Coronary Angiography (CTCA), Traditional Strategy
- Where
- 5 sites in United States
- Volunteers
- 1,392 people
- Sponsor
- American College of Radiology
Ventricular Tachycardia, ICD
Improving Patient Reported Outcome Measures in Catheter Ablation
This study will assess whether more frequent measurement of patient reported outcome measures (PROMs) - specifically health related quality of life (HRQL) - can improve the evaluation of the clinical effectiveness and…
- Conditions
- Ventricular Tachycardia, ICD, Quality of Life
- Trial name
- NCT04499326
- Testing
- Validated quality of life questionnaire (EQ-5D & C-CAP)
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Barts & The London NHS Trust
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