Clinical trials: Cough
COPD, Cough
A Clinical Validation Study to Evaluate the Diagnostic Accuracy of a Cough-based Auxiliary Diagnosis Algorithm for COPD
Cough is one of the most common symptoms in COPD patients, and its different characteristics in amplitude, frequency and waveform can be analyzed by intelligent algorithms for the auxiliary diagnosis of COPD.
- Conditions
- COPD, Cough, Algorithm
- Trial name
- NCT06082791
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Respiratory Tract Diseases
Effect of Effect of a Medicated Topical Therapy , Petrolatum, and No Treatment on Nocturnal Cough
This study seeks to subjectively evaluate whether a single application of Vicks® VapoRub® (VVR) ointment or a control ointment (petrolatum) will be superior to no treatment for control of nocturnal cough and congestion due to…
- Trial name
- NCT00743990
- Testing
- Ointment containing camphor, eucalyptus oil, and menthol, Petroleum jelly
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Penn State University
Pulsed Field Ablation, Lidocaine
Workflow Optimization During Pulse Field Ablation for Atrial Fibrillation
To evaluate the efficacy and safety of intravenous lidocaine in reducing diaphragmatic contraction and suppressing the cough reflex during pulsed field ablation procedures.
- Trial name
- PFA_workflow (NCT07354217)
- Testing
- lidocaine, Saline
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Chronic Obstructive Pulmonary Disease
Postural Drainage With and Without Percussion in Chronic Obstructive Pulmonary Disease
Effects Of postural drainage with and without percussion on mucus clearance, dyspnea and quality of life in Chronic Obstructive Pulmonary disease. 34 Patients will be explained in detail about the procedure under study.
- Trial name
- NCT05649423
- Testing
- POSTURAL DRAINAGE WITH PERCUSSION, Postural drainage
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Pneumonia, Bronchiolitis
Diagnosing Respiratory Disease in Children Using Cough Sounds
The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in diagnosis of pneumonia and other respiratory conditions (bronchiolitis, asthma/reactive airway disease, croup, upper or…
- Conditions
- Pneumonia, Bronchiolitis, Asthma, Croup
- Trial name
- SMARTCOUGH-C (NCT02973282)
- Testing
- Recording of Infants and Children's Cough Sounds
- Where
- 3 sites in United States
- Volunteers
- 1,245 people
- Sponsor
- ResApp Health Limited
COPD Exacerbation, Pertussis
A Multi-center Study to Determine the Prevalence and Influence of Pertussis on COPD Exacerbation in Shenzhen
A prospective, multi-center, observational clinical trail. Aim to evaluate the real incidence of chronic obstructive pulmonary disease (COPD) pertussis and the impact of pertussis on COPD exacerbation.
- Trial name
- NCT04694430
- Testing
- Blood sample, Data collection, Throat swab
- Where
- 27 sites in China
- Volunteers
- 500 people
- Sponsor
- Shenzhen People's Hospital
COVID-19 Pneumonia, Respiratory Disease
The Effect of Deep Breathing and Cough Exercise on Respiratory Parameters in Patients With Covid-19 Associated Pneumonia
Studies reveal that the Covid-19 virus can be transmitted in three ways: respiratory tract, direct contact and feces. The incubation period is estimated to be 5.2 [4.1-7.0] days for the 95% confidence interval and the virus…
- Trial name
- NCT05218200
- Testing
- deep breathing and coughing exercises with triflo
- Where
- Turkey (Türkiye)
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Özge Uçar
Upper-Airway Cough Syndrome
Laryngeal Cryotherapy for Refractory Neurogenic Cough
This study aims to evaluate the safety and efficacy of upper aerodigestive tract cryotherapy treatment in patients with refractory neurogenic cough in a prospective pilot study with a validated patient reported outcome measure
- Trial name
- NCT05665244
- Testing
- Laryngeal cryotherapy, Cryoprobe
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Texas Southwestern Medical Center
COPD
Randomized Trial of the FreeAspire Versus PEP-bottle After Acute Exacerbation in COPD Patients
BACKGROUND: Studies have shown that COPD patients with bronchial hypersecretion have increased risk of acute exacerbations. FREE ASPIRE is an electro-medical device which removes bronchopulmonary secretions noninvasively, without…
- Trial name
- NCT02640430
- Testing
- standard treatment, Free Aspire
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 40 people
- Sponsor
- Maugeri Foundation
Mucociliary Clearance
Evaluating the Effect of Mucinex® 1200 mg on Mucociliary and Cough Clearance From the Human Lung
The purpose of this research study is to test the ability of Mucinex, an oral, over-the-counter, FDA approved expectorant) to stimulate the clearance of inhaled particles from the subject's lungs (called "mucociliary clearance").
- Trial name
- NCT00902707
- Testing
- Mucinex 1200mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Evaluate the Efficacy and Safety of Levotuss CR Tab. in Comparison With Levotuss Syrup in Patients With Cough Due to Acute or Chronic Bronchitis
Phase III Study to Evaluate the Efficacy and Safety of HOB-048 CR Tab. in Comparison With HOB-048 Syrup in Patients With Cough Due to Acute or Chronic Bronchitis
A randomized, double-blind, multicenter, active-controlled phase III study to evaluate the efficacy and safety of Levotuss CR tab. in comparison with Levotuss syrup in patients with cough due to acute or chronic bronchitis
- Trial name
- NCT03489837
- Testing
- Levotuss
- Where
- South Korea
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hyundai Pharm
Chronic Cough (CC), Gastroesophageal Reflux (GER)
Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough
Using an active cohort of children in whom Airway and gastrointestinal endoscopy will be performed, investigators will conduct a chart review to obtain relevant clinical data and the investigators will use an aliquot of airway…
- Trial name
- NCT02797756
- Testing
- Esophago-gastro-duodenoscopy (EGD) with biopsy, Esophageal Impedance Monitoring (EIM)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- NYU Langone Health
Pulmonary Disease, Chronic Obstructive
Study In Subjects With COPD (Chronic Obstructive Pulmonary Disease)
This study was designed to determine if the investigational drug is effective and safe in individuals with COPD (chronic pulmonary disease)
- Trial name
- NCT00103922
- Testing
- cilomilast
- Where
- 115 sites in United States
- Volunteers
- 600 people
- Sponsor
- GlaxoSmithKline
Cough
Prevalence and Main Features of Chronic Refractory Cough.
Cough is among the most common causes of medical consultation in primary care.[1] Chronic cough, arbitrarily defined as symptom persisting more than 8 weeks, has been variably reported in different settings and geographical area…
- Trial name
- ASSESS-CRC (NCT04078542)
- Where
- 4 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Campus Bio-Medico University
Post-extubation Failure, Persistent Weaning Failure
Effects of Mechanical Insufflation-Exsufflation in Preventing Respiratory Failure After Extubation
Weaning protocols that include the use of noninvasive ventilation (NIV), decreases the incidence of re-intubation and ICU length of stay. However, the role of NIV in post-extubation failure is still not clear.
- Conditions
- Post-extubation Failure, Persistent Weaning Failure, Secretion Encumbrance, Weak Cough
- Trial name
- MIEICU (NCT01424202)
- Testing
- Mechanical Insufflation Exsufflation
- Where
- Portugal
- Volunteers
- 92 people
- Sponsor
- Hospital Sao Joao
Asthma, Cough Variant Asthma
Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly.
- Trial name
- NCT01064245
- Testing
- high-dose methacholine challenge test, mannitol challenge test
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Dr. Diane Lougheed
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Stimulation to Restore Cough
The purpose of this trial is to determine the efficacy of spinal cord stimulation to produce an effective cough in patients with spinal cord injuries.
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT00116337
- Testing
- Spinal Cord Stimulation to restore cough, Expiratory Muscle Stimulator
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MetroHealth Medical Center
Hepatitis B
Immune Response Post Pry Vaccination of 2 Formulations of DTPw-HBV Vaccine Given With Rotavirus Vaccine to Infants
To compare the two formulations of GSK Biologicals' DTPw-HBV vaccine to concomitant administration of CSL's DTPw vaccine and GSK Biologicals' HBV with respect to the antibody response to the diphtheria antigen after a three-dose…
- Trial name
- NCT00158756
- Testing
- Tritanrix™-HepB, Rotarix™, Zilbrix™
- Where
- 9 sites in Russia
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pertussis/Whooping Cough
The Optimal Timing of Vaccination in Pregnancy
The central aim of this study is to investigate the optimal timing of vaccination in pregnant women. Therefore, pregnant women will be vaccinated against pertussis at different timepoints and blood and breast milk samples will be…
- Trial name
- MATIMMUNE (NCT06466629)
- Testing
- Triaxis, Sanofi Pasteur
- Where
- Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Elke Leuridan, MD, PhD
Common Cold Associated With Cough
Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and Cough
This study is designed to improve knowledge regarding the initial effectiveness of N-acetylcysteine (NAC) on cold and cough symptoms.
- Trial name
- NAC cold cough (NCT02379637)
- Testing
- N-acetylcysteine
- Where
- 5 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Novartis