Clinical trials: Coughing
Thoracic Surgery
ACBT With Incentive Spirometry Versus High-Frequency Chest Wall Oscillation After Thoracic Surgery
This randomized clinical trial aims to compare the effectiveness of Active Cycle of Breathing Techniques combined with Incentive Spirometry (ACBT + IS) versus High-Frequency Chest Wall Oscillation (HFCWO) in patients undergoing…
- Trial name
- NCT07619716
- Testing
- Active Cycle of Breathing Techniques with Incentive Spirometry, High-Frequency Chest Wall Oscillation
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Cough Variant Asthma
Observation of Cough Variant Asthma Treated in Combination of Chanqin Granules.
This single-center, randomized, double-blind, placebo-controlled trial was undertaken at an outpatient clinic in Shuguang Hospital. Newly diagnosed cough variant asthma adult patients with the T.C.M.
- Trial name
- NCT03319043
- Testing
- Chanqin granules
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Non-cystic Fibrosis Bronchiectasis
Phase 2a, 28-day Investigational Use Study of ARINA-1 in Non-Cystic Fibrosis Bronchiectasis (NCFBE) With Excess Mucus and Cough
This is a randomized, Phase 2a, double-blind, placebo-controlled study to evaluate the safety and efficacy of ARINA-1 compared to placebo (isotonic saline, 0.9%) in participants with NCFBE.
- Trial name
- NCT05495243
- Testing
- ARINA-1
- Where
- 10 sites in United States
- Volunteers
- 40 people
- Sponsor
- Renovion, Inc.
Sore Throat, Cough
Effect of Betamethasone Gel and Lidocaine Jelly on Sore Throat, Cough and Hoarseness of
ABSTRACT: The aim of this study was to investigate the effect of betamethasone gel and lidocaine jelly (over tracheal tube cuff) compared with distilled water on the post intubation syndrome incidence.
- Trial name
- NCT02114021
- Testing
- betamethasone gel, lidocaine jelly, distilled water
- Where
- Iran
- Volunteers
- 99 people
- Sponsor
- Tehran University of Medical Sciences
Cough
A Prospective Trial of Behavioral Therapy for Chronic Cough
This study seeks to explore whether heart rate variability (HRV) biofeedback can be effective in the treatment of chronic cough.
- Trial name
- NCT03235466
- Testing
- Voice Therapy, Voice Therapy and Heart Rate Variability Biofeedback, Heart Rate Variability Biofeedback
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Premature Ventricular Complexes
Physical Impairments in Premature Ventricular Complex
Premature ventricular complexes may be observed in individuals without underlying disease due to factors such as physical inactivity, advanced age, smoking, male sex, and psychosocial disturbances, and in some cases may result in…
- Trial name
- NCT07396597
- Testing
- Physical Evaluations of Patients with Premature Ventricular Complex, Physical Evaluations of Healthy Individuals
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Asthma
The Evaluation of FeNO for Predicting Response to ICS in Subjects With Non-specific Respiratory Symptoms
Nitric Oxide is recognized as a biological marker for many chronic airway diseases. It has been standardised for clinical use indicating airway inflammation.
- Trial name
- NSRS (NCT02294279)
- Testing
- Qvar (100 mcg)
- Where
- United Kingdom
- Volunteers
- 360 people
- Sponsor
- Research in Real-Life Ltd
Refractory or Unexplained Chronic Cough
Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough
This is a phase 2b, randomized, double-blind, placebo-controlled study investigating the efficacy, safety, and tolerability of Taplucainium Inhalation Powder (NOC-110) once daily in adults with refractory or unexplained chronic…
- Trial name
- ASPIRE (NCT06504446)
- Testing
- NOC-110
- Where
- 106 sites in United States, Belgium and 4 more
- Volunteers
- 455 people
- Sponsor
- Nocion Therapeutics
Infections, Respiratory, Fever
Impact of Swab Site and Sample Collector on Testing Sensitivity for COVID-19 Virus in Symptomatic Individuals
Operational project to compare clinician collected nasopharyngeal (NP) samples to patient-obtained tongue, nasal and mid-turbinate (MT) samples in the detection of SARS-CoV-2 in an outpatient clinic setting
- Conditions
- Infections, Respiratory, Fever, Cough
- Trial name
- NCT04321369
- Testing
- Testing Sensitivity for SARS-CoV-2 Virus in Symptomatic Individuals
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- UnitedHealth Group
Varicella, Measles
Immunogenicity and Safety Study of Proquad® and Infanrix® Hexa When Administered Concomitantly (V221-035)
Primary Objective: To demonstrate that ProQuad® can be administered concomitantly with a booster dose of Infanrix® hexa to healthy children 12 to 23 months of age without impairing either the antibody response rates to measles…
- Conditions
- Varicella, Measles, Mumps, Rubella
- Trial name
- NCT00432042
- Testing
- ProQuad®, Infanrix® hexa
- Where
- 50 sites in Germany, Italy
- Volunteers
- 955 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diphtheria, Tetanus
Study of an Investigational Vaccine in Healthy Infants in Taiwan (V441-001)(COMPLETED)
The purpose of this study is to evaluate the safety, tolerability, and immune response of an investigational vaccine being evaluated to reduce the incidence of diphtheria, pertussis, tetanus, hepatitis B, poliomyelitis, and…
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT00092469
- Testing
- V441, diptheria, tetanus, acellular pertussis, inactivated poliomyelitis, hepatitis B (recombinant), & Haemophilus influenza type b conjugate vaccine
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Spinal Cord Injuries
Spinal Stimulation + FES-Assisted Cough Training in SCI
The overall objective of this proposal is to determine if transcutaneous spinal cord stimulation (tSCS) delivered concurrently with functional electrical stimulation (FES)-assisted cough training (FES-Cough) is an effective…
- Trial name
- NCT07683780
- Testing
- tSCS combined with FES-Cough
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Milap Sandhu
Chronic Obstructive Airway Disease, Asthma
Cough Responses to Tussive Agents in Health and Disease
The sensitivity of a persons cough reflex can be measured by getting them to breath in (inhale) irritant chemicals. The purpose of this clinical research study is to test the sensitivity of the cough reflex to a variety of…
- Conditions
- Chronic Obstructive Airway Disease, Asthma, Chronic Cough
- Trial name
- NCT01297790
- Testing
- Cough Challenge Tests, ambulatory cough recording, Cough questionnaires
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Refractory Chronic Cough
Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 2b adaptive dose-finding study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
- Trial name
- SOOTHE (NCT04678206)
- Testing
- BLU-5937
- Where
- 116 sites in United States, Canada and 5 more
- Volunteers
- 310 people
- Sponsor
- Bellus Health Inc. - a GSK company
Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis
Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
The purpose of this study is to determine whether lozenges containing interferon-alpha can reduce the frequency and severity of coughing in patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Cough
- Trial name
- NCT00690885
- Testing
- interferon-alpha lozenges
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
Coughing Response, Thyroid Surgery
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway…
- Conditions
- Coughing Response, Thyroid Surgery, General Anesthesia
- Trial name
- NCT02613806
- Testing
- Dexmeditomidine, normal saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Asthma, Smoking Cessation
Pediatric Emergency Department Decision Support System to Reduce Secondhand Smoke
This two phase study will develop and evaluate a Pediatric Emergency Department (PED) Decision Support System (DSS)-Electronic Medical Records (EMR) System to facilitate the identification of smokers and the delivery of a Second…
- Trial name
- NCT02489708
- Testing
- Cessation Counseling
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Idiopathic Pulmonary Fibrosis, Cough
Does CBT Improve the Perception/Impact of Cough and Breathlessness in IPF Patients
Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease of unknown cause for which there is no effective medical treatment.
- Conditions
- Idiopathic Pulmonary Fibrosis, Cough, Breathlessness
- Trial name
- NCT01738711
- Testing
- Cognitive behavioural therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Victoria Infirmary
Chronic Cough, Video-assisted Thoracoscopic Surgery (VATS)
A Prospective, Randomized, Double-blind Study on the Effects of Different Anesthesia Strategies on Postoperative Cough in Patients Undergoing Video-assisted Thoracoscopic Surgery.
This study aims to systematically evaluate the effects of different anesthesia methods on postoperative chronic cough in lung cancer patients undergoing video-assisted thoracoscopic lung resection (VATS), and to clarify the…
- Trial name
- Chronic cough (NCT07190664)
- Testing
- Patients were randomly grouped
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Poliomyelitis
Study to Evaluate the Safety of Co-administration of GSK Biologicals' Poliorix and Infanrix in Healthy Children in Russia
The purpose of this study is to assess reactogenicity and safety of simultaneous administration of GSK Biologicals' inactivated poliomyelitis vaccine Poliorix and GSK Biologicals' DTPa-vaccine Infanrix vaccines in healthy…
- Trial name
- NCT01094171
- Testing
- Poliorix TM, Infanrix TM
- Where
- 2 sites in Russia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline