Clinical trials: Couples
Obstructive Sleep Apnea, CPAP Treatment
OurSleepKit To Support CPAP Adherence
The goal of this clinical trial is to learn if a couple-focused mobile health intervention will improve the use of continuous positive airway pressure (CPAP), the primary treatment option for obstructive sleep apnea (OSA).
- Conditions
- Obstructive Sleep Apnea, CPAP Treatment, Treatment Adherence
- Trial name
- NCT06621511
- Testing
- OurSleepKit
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Infertility
ICSI Versus Conventional IVF in Non-male Factor Couples
Conventionally, ICSI was initially developed and has been shown to be an effective treatment for male factor infertility. It is increasingly being used for patients without a male factor diagnosis, despite the lack of clinical…
- Trial name
- NCT03428919
- Testing
- ICSI, IVF
- Where
- Vietnam
- Volunteers
- 1,064 people
- Sponsor
- Mỹ Đức Hospital
Polycystic Ovary Syndrome
History of Polycystic Ovary Syndrome in First-degree Relatives
The aim of this study was to investigate the semen analysis results of male patients with first-degree relatives meeting the diagnostic criteria for PCOS.
- Trial name
- PCOS (NCT06442228)
- Testing
- spermiogram test
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Couples Eligible for Prenatal Exome Sequencing
Parallel Sequencing of Fetal Genome and RNA in the Presence of Ultrasound Warning Signs: a Complementary Approach for the Prenatal Diagnosis of Rare Diseases.
Prenatal exome sequencing (ES) is increasingly used for fetuses with ultrasound-detected anomalies but yields 10-15% variants of uncertain significance (VUS), limiting diagnostic performance, particularly in prenatal settings…
- Trial name
- PrenOmics (NCT07790536)
- Testing
- Genome Sequencing (GS) + RNA-Sequencing (RNA-Seq)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain
Study to Understand Pain Experiences in Relationships
Chronic pain is a highly prevalent and costly health care problem. Yet, little is known about the optimal ways for health care providers and family members to respond to the distress expressed by people with chronic pain.
- Trial name
- SUPER (NCT02859545)
- Testing
- Emotional Validation Training for Romantic Partners, Chronic Pain Education Training for Romantic Partners
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wayne State University
Recurrent Pregnancy Loss
On Pregnancy After Losses - OPAL Study
Rationale: Recurrent pregnancy loss (RPL) is defined as the loss of two or more conceptions before the fetus reaches viability. It affects 1-3% of all fertile couples and despite extensive diagnostic work-up, in only around 30%…
- Trial name
- OPAL (NCT05167812)
- Testing
- Observation of pregnancies after intake
- Volunteers
- 1,931 people
- Sponsor
- Leiden University Medical Center
Breast Cancer
Couple-Focused Intervention for Breast Cancer Patients
The goal of the proposed study is to evaluate the efficacy of 2 couple-focused interventions developed to reduce the psychological distress on women and their partners during and after the breast cancer experience.
- Trial name
- NCT00940277
- Testing
- Group Counseling
- Where
- 5 sites in United States
- Volunteers
- 611 people
- Sponsor
- Fox Chase Cancer Center
Huntington Disease
Couple and Spouse Caregiver in Huntington's Disease
The objectives are to better document the psychosocial status and needs of caregiver of HD patients and understand the dyad functioning, facing the disease at various stages.
- Trial name
- COCOON (NCT04394767)
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Obstructive Sleep Apnea
We-PAP: A Couples-based Intervention for Sleep Apnea
The purpose of this study is to develop, refine and evaluate the feasibility of a novel couples-based intervention to improve adherence for patients with obstructive sleep apnea (OSA).
- Trial name
- We-PAP (NCT04759157)
- Testing
- Couples-based treatment, Standardized education
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Utah
HIV, Sexually Transmitted Diseases
Zambia One Love Aim 3 Trial
The aim of this study is to determine whether a Strengthening our Vows (SOV) intervention will reduce HIV exposures from concurrent partnership (CP) when compared to the control Good Health Package Plus (GHPP), in addition to…
- Conditions
- HIV, Sexually Transmitted Diseases, Neglected Diseases, Non-communicable Diseases
- Trial name
- NCT02744586
- Testing
- Strengthening Our Vows (SOV), Good Health Package Plus (GHPP)
- Where
- 2 sites in Zambia
- Volunteers
- 3,450 people, healthy volunteers welcome
- Sponsor
- Emory University
Human Immunodeficiency Virus
Jamii Bora: A Home-Based Couples Intervention
The purpose of the study is to develop and pilot-test a home-based intervention to facilitate sate HIV testing and disclosure within pregnant couples in order to increase use of prevention-of-mother-to-child-transmission (PMTCT)…
- Trial name
- NCT02403583
- Testing
- Intervention- Home Visits
- Where
- 5 sites in Kenya
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Maternal Death, Maternal Behavior
Effectiveness of Health Education Provided to Couples on Utilization of Maternity Waiting Homes in Rural Ethiopia
Maternity waiting homes (MWHs) were identified as a solution to improve pregnancy outcomes by bringing women living in geographically isolated areas closer to a healthcare facility.
- Trial name
- NCT05015023
- Testing
- Behavioral intervention
- Where
- Ethiopia
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Jimma University
Family Relations
Testing Relationship Skills Education Services With a Robust Economic Security Component
The Parenting Center (TPC) offers the Empowering Families program, which integrates a relationship education curriculum (Family Wellness) into a comprehensive set of services that includes case management, employment services…
- Trial name
- TPC (NCT02902003)
- Testing
- Empowering Families
- Where
- United States
- Volunteers
- 1,758 people, healthy volunteers welcome
- Sponsor
- Mathematica Policy Research, Inc.
Infertility
Swanson-Based Supportive Care for Infertility Stress and Coping in Couples Undergoing ART
The goal of this clinical trial is to learn if supportive care based on Swanson's Caring Theory can reduce stress and improve coping in couples undergoing infertility treatment with assisted reproductive treatment (ART)…
- Trial name
- NCT07557069
- Testing
- Swanson Caring Theory-based supportive care
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ondokuz Mayıs University
Pregnancy, Sexually Transmitted Disease
Performance and Safety Trial of an Innovative Female Condom (Wondaleaf®)
General objective: To assess the performance and safety profile of a novel innovative design of female condom (Wondaleaf®) among healthy married women.
- Trial name
- NCT02593214
- Testing
- Wondaleaf®
- Where
- Malaysia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Clinical Research Centre, Malaysia
HIV Infections, Hiv
Acceptability, Feasibility, and Preliminary Impact of a Web-based, HIV Prevention Toolkit With Cisgender Male Couples in Lima, Peru
This digital couples-based HIV/STI prevention intervention project will determine preliminary efficacy to improve uptake of evidence-based strategies and a tailored prevention plan among cisgender male couples who are in a…
- Conditions
- HIV Infections, Hiv, Sexually Transmitted Infections (Not HIV or Hepatitis), Sexually Transmitted Diseases
- Trial name
- NCT05873855
- Testing
- Para ti, para mi, para nosotros (P3), Waitlist Control Para ti, para mi, para nosotros (P3)
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Florida International University
HIV
HIV Prevention Toolkit for HIV-negative Male Couples
Though technology is integrated into the lives of our target population, use of any particular technology will depend on the content delivered, aesthetic appeal, and overall design.
- Trial name
- MCAP (NCT02494817)
- Testing
- Male Couples Agreement Project
- Where
- United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Miami
HIV Infections, Pregnancy Related
Happy Homes, Healthy Families: A Relationship Strengthening Intervention for Pregnant Couples Affected by HIV in Zambia
The objective of this study is to test the preliminary efficacy of a novel couples' counseling intervention to promote the health of pregnant women living with HIV in Lusaka, Zambia.
- Trial name
- NCT04729413
- Testing
- Couples Counseling, Enhanced Standard of Care
- Where
- Zambia
- Volunteers
- 478 people
- Sponsor
- University of Colorado, Denver
Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm
Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners
This pilot clinical trial studies how well acceptance and commitment therapy works in improving well-being in patients with stage III-IV cancer and their partners.
- Conditions
- Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm, Partner, Stage III Breast Cancer
- Trial name
- NCT03112668
- Testing
- Cognitive Behavior Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Use Disorder, Posttraumatic Stress Disorder
Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship
Intimate partner violence (IPV) is a serious public health problem that results in significant health and economic burdens including mortality, morbidity, and poor treatment outcomes.
- Conditions
- Alcohol Use Disorder, Posttraumatic Stress Disorder, Couples
- Trial name
- NCT05786157
- Testing
- Alcohol Administration
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina