Clinical trials: Couples, open to volunteers
Infertility, Male
Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples
The purpose of this research study is to evaluate if special types of cells called round spermatids can be gathered from men with non-obstructive azoospermia and used (in absence of elongated spermatids and spermatozoa) to…
- Trial name
- ROSI (NCT04298255)
- Testing
- Round Spermatid Injection (ROSI), Half ROSI-half Sperm Donor Fertilization
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Pregnancy, Postpartum
Supporting the Transition to Parenthood Through Online Sex and Relationship Knowledge
Becoming parents exerts powerful and long-lasting effects on couples' well-being and quality of life. The transition to parenthood (TtP; pregnancy to 12-months postpartum) poses significant challenges as couples balance the task…
- Trial name
- STORK (NCT07344454)
- Testing
- STORK Program
- Where
- 2 sites in Canada
- Volunteers
- 268 people
- Sponsor
- Dalhousie University
Alcohol; Use, Problem
Using EMA Data to Inform a Web-intervention for Couples Concerned About Drinking
Alcohol misuse is a prevalent and serious problem with significant harms to society, individuals, and their relationships. Romantic partners have a strong influence on their partner's behavior, uniquely positioning them as a…
- Trial name
- NCT06501677
- Testing
- WBI
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Stanford University
Postoperative Pain, Shoulder Arthroscopic Surgeries
Exparel and Dexamethasone
This prospective randomized clinical trial evaluates the duration of sensory blockade in patients undergoing shoulder surgery receiving interscalene brachial plexus blocks with either liposomal bupivacaine alone or liposomal…
- Trial name
- NCT07614802
- Testing
- Liposomal Bupivacaine with Bupivacaine, Dexamethasone
- Volunteers
- 80 people
- Sponsor
- Duke University
Romantic Relationship Functioning
Mindfulness in Couples
Considering the high prevalence of couple distress in Western countries and rising divorce rates, there is a pressing need for accessible and evidence-supported interventions that can strengthen relationship functioning.
- Trial name
- NCT07433582
- Testing
- SE training, MBCI
- Where
- Netherlands
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Behavioural Science Institute
Obstructive Sleep Apnea, CPAP Treatment
OurSleepKit To Support CPAP Adherence
The goal of this clinical trial is to learn if a couple-focused mobile health intervention will improve the use of continuous positive airway pressure (CPAP), the primary treatment option for obstructive sleep apnea (OSA).
- Conditions
- Obstructive Sleep Apnea, CPAP Treatment, Treatment Adherence
- Trial name
- NCT06621511
- Testing
- OurSleepKit
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Couples Eligible for Prenatal Exome Sequencing
Parallel Sequencing of Fetal Genome and RNA in the Presence of Ultrasound Warning Signs: a Complementary Approach for the Prenatal Diagnosis of Rare Diseases.
Prenatal exome sequencing (ES) is increasingly used for fetuses with ultrasound-detected anomalies but yields 10-15% variants of uncertain significance (VUS), limiting diagnostic performance, particularly in prenatal settings…
- Trial name
- PrenOmics (NCT07790536)
- Testing
- Genome Sequencing (GS) + RNA-Sequencing (RNA-Seq)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Recurrent Pregnancy Loss
On Pregnancy After Losses - OPAL Study
Rationale: Recurrent pregnancy loss (RPL) is defined as the loss of two or more conceptions before the fetus reaches viability. It affects 1-3% of all fertile couples and despite extensive diagnostic work-up, in only around 30%…
- Trial name
- OPAL (NCT05167812)
- Testing
- Observation of pregnancies after intake
- Volunteers
- 1,931 people
- Sponsor
- Leiden University Medical Center
Alcohol Use Disorder, Posttraumatic Stress Disorder
Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship
Intimate partner violence (IPV) is a serious public health problem that results in significant health and economic burdens including mortality, morbidity, and poor treatment outcomes.
- Conditions
- Alcohol Use Disorder, Posttraumatic Stress Disorder, Couples
- Trial name
- NCT05786157
- Testing
- Alcohol Administration
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder
Intensive Multi-Couple Therapy for PTSD Versus Relationship Education in Military Couples
The goal of this clinical trial is to test an abbreviated, intensive, multi-couple group version of cognitive-behavioral conjoint therapy for PTSD (AIM-CBCT for PTSD) in an active military and veteran population.
- Trial name
- NCT06047691
- Testing
- Abbreviated, Intensive, Multi-Couple Group Cognitive-Behavioral Conjoint Therapy for PTSD, Prevention and Relationship Education Program
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Penn State University
Infertility
Outcomes of Couples After Failed PGD Management: A Single-Center Study at the Paris PGD Center (Antoine Béclère - Necker)
Preimplantation genetic testing (PGT) is a reproductive genetic technique aimed at preventing the transmission of severe genetic disorders.
- Trial name
- DECOPI (NCT07371312)
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blood Pressure, Sleep
Multidimensional Sleep Health Intervention for Couples
The goal of this pilot dyadic study is to adapt a multidimensional sleep health (MDSH) intervention, previously disseminated at the individual level, for relationship partners, determine whether it improves sleep health and…
- Conditions
- Blood Pressure, Sleep, Cardiovascular Health
- Trial name
- DREAM-COUPLES (NCT07603245)
- Testing
- Multidimensional Sleep Health Promotion Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Columbia University
Infertility, Male Infertility
The Efficiency of a New Sperm-Wash Device for Intrauterine Insemination in Couples With Infertility
This study evaluates the effectiveness of a novel sperm-wash device designed to improve outcomes in intrauterine insemination (IUI) for couples with infertility.
- Trial name
- IUI (NCT06956287)
- Testing
- LensHooke CA0, Density Gradient Centrifugation (DGC)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chung Shan Medical University
Depression Anxiety Disorder, Anxiety
EFCT vs. BCT for Depression and Anxiety in Married Couples
This study compares the effectiveness of Emotion-Focused Couples Therapy (EFCT) and Behavioral Couples Therapy (BCT) in reducing depression and anxiety symptoms in married couples.
- Trial name
- EFCT-BCT (NCT06892613)
- Testing
- Emotion-Focused Couples Therapy (EFCT), Behavioral Couples Therapy (BCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beykoz University
Suicidal Ideas, Suicidal Ideation
Couple-Based Crisis Safety Planning
Suicide is a leading cause of death in Veterans. Suicide rates among Veterans have increased approximately 36% from 2001 to 2020.
- Conditions
- Suicidal Ideas, Suicidal Ideation, Crisis; Emotional, Suicide Attempts
- Trial name
- CRP-C (NCT07012824)
- Testing
- Crisis Response Planning, Couples-based Crisis Response Planning
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Autism Spectrum Disorder
Establish the Couple Intervention Program for Adults With Autism Spectrum Disorder
The development of adult intimate relationships and the transition into couplehood are part of most people's life cycles, but these transitions become very challenging for individuals diagnosed with autism spectrum disorder (ASD)…
- Trial name
- NCT05875376
- Testing
- Couple group therapy
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Smoking, Cigarette
Dyadic Financial Incentive Treatments for Dual Smoker Couples
Smokers partnered with other smokers (i.e., dual-smoker couples) represent ~2/3 of all smokers. Dual-smoker couples (DSCs) are less likely to try to quit smoking and more likely to relapse during a quit attempt, reducing overall…
- Trial name
- NCT06296849
- Testing
- Financial Incentive Treatment (FIT)
- Where
- 2 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
HIV Infections
Evaluating the Efficacy of Annual CHTC Retesting Among Male Couples at High Risk of HIV Infection
This randomized controlled trial evaluates the efficacy of couples HIV testing and counseling retesting. Eligible couples previously enrolled in NCT05000866 are invited to participate.
- Trial name
- 4Us Part B (NCT05833074)
- Testing
- Couples HIV testing and counseling, Individual HIV testing and counseling
- Where
- 2 sites in United States
- Volunteers
- 384 people
- Sponsor
- Hunter College of City University of New York
Heavy Episodic Drinking
Understanding the Associations Between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse Among Emerging Adults
Emerging Adults (EA) engage in heavy episodic drinking (HED) at a greater quantity and frequency than any other time in their lives, which may lead to significant short- and long-term consequences.
- Trial name
- NCT06976528
- Testing
- Alcohol administration
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- New York University
Diabetes Prevention, GDM
Couple-Coordinated Lifestyle Intervention for Women With a History of Gestational Diabetes Mellitus
The goal of this clinical trial is to evaluate the effects of a couple-based collaborative lifestyle intervention among women with a history of gestational diabetes.
- Conditions
- Diabetes Prevention, GDM, Lifestyle Intervention, Couples
- Trial name
- NCT07762625
- Testing
- Couple-based Collaborative Lifestyle Intervention, Woman-only Lifestyle Intervention
- Where
- 3 sites in China
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University