Clinical trials: Covid19 Immunology
COVID-19 Prevention
An Open Study on the Safety, Tolerability, and Immunogenicity of "Sputnik Light" Vaccine
Phase I-II open prospective, two-stage, non-randomized study in healthy volunteers.
- Trial name
- NCT04713488
- Testing
- Sputnik Light
- Where
- Russia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
COVID-19
Phase I Study to Assess the Safety and Immunology of a COVID-19 Vaccine With GRAd-COV2 Vaccine
RT-CoV-2 is a Phase I, open-label, dose escalation multicenter clinical trial to assess safety and immunogenicity of the candidate Coronavirus disease (COVID-19) vaccine GRAd-COV2 in Italian healthy volunteers aged 18-55 years…
- Trial name
- NCT04528641
- Testing
- GRAd-COV2
- Where
- 2 sites in Italy
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- ReiThera Srl
Influenza, Human, SARS-CoV-2 Infection
Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection
The objectives of this study are to understand the long-term consequences of repeated annual influenza vaccination among healthcare workers (HCWs) and to use statistical and mathematical modelling to elucidate the immunological…
- Trial name
- NCT05110911
- Testing
- Influenza vaccination: Fluarix Tetra, Vaxigrip Tetra, Fluquadri, Fluad Quad, Afluia Quad, Flucelvax Quad, SARS-CoV-2 vaccination: Comirnaty or Vaxzevria
- Where
- 6 sites in Australia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Covid19, Kidney Transplantation
Monitoring of COVID-19 Vaccine Response in Organ Transplant Patients
Vaccination against SARS CoV-2 appears to be the best strategy today to control the COVID-19 pandemic. The first published studies with Pfizer, Moderna and Astra-Zeneca vaccines show very good vaccine protection in the general…
- Trial name
- COVATRANS (NCT04828460)
- Where
- France
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Strasbourg, France
Virus-HIV, Covid19
Impact of the Epidemic of COVID-19 Infection Among People Living With HIV (SARS-CoV-2)
The non-essential and non-urgent follow-up consultations of patients living with HIV were postponed or transformed into "teleconsultation" or exchanges of e-mails between practitioners and patients during COVID-19 epidemic.
- Trial name
- coVIHd-19 (NCT04581746)
- Testing
- questionnaire
- Where
- 3 sites in France
- Volunteers
- 1,800 people
- Sponsor
- Tourcoing Hospital
Covid19, SARS-CoV Infection
Characterization Immunology, Biochemical and Lung Microbiome, Correlated With the Ventilation Associated Pneumonia (VAP)
SARS-CoV-2, the virus that causes COVID-19, is currently a global public health problem, declared a pandemic by the World Health Organization, which today has more than one million deaths in the world, of which , 30,000…
- Trial name
- MicroNAV-II (NCT04944823)
- Testing
- Clinical follow-up for 24 months
- Where
- Colombia
- Volunteers
- 50 people
- Sponsor
- Universidad de la Sabana
Allogenic Hematopoietic Cell Transplant, CAR-T Therapy
COVID-19 Vaccine in Patients After Allogeneic HCT, CAR-T Therapy and With Primary Immune Deficiency
The corona pandemic is a continuing global challenge due to Corona Virus 2019 (COVID-19). The purpose of the study is to confirm the accepted hypothesis from the recommendations of The European Society for Blood and Marrow…
- Conditions
- Allogenic Hematopoietic Cell Transplant, CAR-T Therapy, Primary Immunodeficiency
- Trial name
- NCT04724642
- Where
- Israel
- Volunteers
- 110 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Covid-19, Health Personnel
Seroconversion Among Staff at a Large Acute Care Hospital in Denmark During the COVID-19 Pandemic
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in samples collected from HCWs in an acute hospital.
- Conditions
- Covid-19, Health Personnel, Personnel, Hospital
- Trial name
- NCT04431310
- Testing
- Serial seroconversion measurements in hospital employees during the COVID-19 pandemic
- Where
- 2 sites in Denmark
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Immunodeficiency, Immunosuppression
ImmunoCARE: Rapid, Accurate COVID Testing to Reduce Hospitalization of Immunocompromised Individuals
The investigators will examine whether a combination of at-home nucleic acid amplification tests, on-demand telemedicine, and delivery of prescriptions such as Paxlovid quickly after testing positive for COVID-19, can reduce…
- Conditions
- Immunodeficiency, Immunosuppression, HIV Infections, Graft Versus Host Disease
- Trial name
- NCT05655546
- Testing
- Access to Cue Health COVID-19 Remote testing and treatment for COVID-19
- Where
- United States
- Volunteers
- 2,117 people
- Sponsor
- Scripps Translational Science Institute
Allergy and Immunology, Infection Viral
Evaluation of Immune Response in COVID-19 Patients
The aim of the project is to evaluate the immunological features of COVID-19 patients. Patients are recruited without any pharmacological treatments restriction.
- Trial name
- IMMUNOVID (NCT04438629)
- Testing
- COVID-19 treatment
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Nephrotic Syndrome, Focal Segmental Glomerulosclerosis
Predictive Determinants of Nephrotic Syndrome Remission in Patients With At-risk Polymorphism of APOL1
This is a multicentric retrospective observational cohort study. As primary objective, the study aims to evaluate the factors associated with nephrotic syndrome remission in patient with nephrotic syndrome, biopsy-prove minimal…
- Conditions
- Nephrotic Syndrome, Focal Segmental Glomerulosclerosis, APOL1 Associated Kidney Disease
- Trial name
- NEPHROL1 (NCT06443034)
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections, Covid19
Safety and Immune Response of COVID-19 Vaccination in Patients With HIV Infection
On 11 February 2020, the International Committee for the Classification of Viruses named the disease caused by SAＲS-CoV-2 infection in humans as the new coronavirus pneumonia (coronavirus disease 2019, COVID-19).
- Trial name
- NCT05043129
- Testing
- Biological/Vaccine: SARS-COV-2 VACCINE
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Immune Deficiency
Covid-19 Vaccine Cohort in Specific Populations
Multicentre national cohort study with prospective data collection and biological specimen collection. Ancillary study in this cohort : pediatric cohort with participants from 5 to 17 years old.
- Trial name
- COV-POPART (NCT04824651)
- Testing
- COVID-19 vaccine
- Where
- 3 sites in France
- Volunteers
- 6,922 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Covid19 Immunology
The COVID-19 PUI Reality Check (CPRC) Study
This study compares SARS-CoV-2 immune responses in high pretest probability swab negative hospitalized PUI patients vs. low pretest probability swab negative hospitalized APS (Asymptomatic Persons being Screened) patients to try…
- Trial name
- CPRC (NCT04474288)
- Testing
- SARS-CoV-2 antibody testing
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Bassett Healthcare
SARS-CoV2 Infection, Multisystem Inflammatory Syndrome in Children
MISC COVID-19 Study in Pediatric Population
Rationale: Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV2) and its related Coronavirus Disease - 19 (COVID-19) has become a health emergency worldwide.
- Trial name
- COVID-19 (NCT04844242)
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Tuberculosis Research Centre, India
COVID-19, HIV Seropositivity
Collision of Three Global Pandemics: the Effect of Tuberculosis and HIV on the Epidemiological, Clinical, Virological and Immunological Trajectory of COVID-19 in Botswana and Namibia
COVID-19 has emerged as global pandemic during the past few months, with an unprecedented impact on public health, and society more generally.
- Conditions
- COVID-19, HIV Seropositivity, Tuberculosis, Pulmonary, Tuberculosis Infection
- Trial name
- Core-NB (NCT05268380)
- Testing
- Covid-19, TB and HIV diagnosis
- Where
- Namibia
- Volunteers
- 1,750 people
- Sponsor
- University of Namibia
Covid19, Lymphopenia
Nicotinamide-based Supportive Therapy in Lymphopenia for Patients With COVID-19
The mechanism of peripheral blood lymphocyte decline in COVID-19 patients is not yet clear. However, one theory demonstrated that in the whole progression of COVID-19, the extensive activation of poly-ADP-ribose polymerase (PARP)…
- Trial name
- NCT04910230
- Testing
- nicotinamide
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Qiang Hu
Hiv, Depression in Old Age
Creating a Virtual Village for People Aging With HIV During COVID-19
In a PCORI-funded project on HIV and aging engagement that was co-led by the study team, the topics of isolation and depressions were identified as priority areas of deep concern among older PLWH.
- Conditions
- Hiv, Depression in Old Age, Isolation, Social, Aging
- Trial name
- NCT04747756
- Testing
- Virtual Village
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Covid19, Geriatric Medicine
COVID-19 Serology and Immunosenescence
This study aims to determine how long COVID-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors.
- Conditions
- Covid19, Geriatric Medicine, Seroconversion, Immunosenescence
- Trial name
- SERO-CoV-OLD (NCT04563650)
- Testing
- blood sample
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HIV Infections, SARS-CoV-2 Infection
COVID-19 Serology in People Living with HIV in Hong Kong
Immunodeficiency associated with human immunodeficiency virus (HIV) infection could predispose people living with HIV/AIDS (PLHA) to defective serological responses following infection or vaccination.
- Conditions
- HIV Infections, SARS-CoV-2 Infection, Vaccination; Infection
- Trial name
- NCT05028881
- Testing
- blood sampling
- Where
- China
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong