Clinical trials: Covid19 Vaccination
Covid19, Vaccines
Efficacy, Safety, and Immunogenicity of Two Vaccination Schedules of an Inactivated Vaccine Against COVID-19 in Adults
The study will evaluate the efficacy, safety, and immunogenicity of two vaccination schedules of an inactivated vaccine against SARS-CoV-2 infection in adults.
- Trial name
- CoronaVac3CL (NCT04651790)
- Testing
- SARS-CoV-2 inactivated vaccine
- Where
- Chile
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Wellness, Burnout, Caregiver
Evaluating the Impact of Resource Navigators to Support LTC and RH Staff During and Beyond COVID-19
The goal of this clinical trial is to test how well resource navigators help long-term care and retirement home staff access the various health and wellness resources available to them and the effects that this has on their…
- Conditions
- Wellness, Burnout, Caregiver, Burnout, Professional, COVID-19
- Trial name
- NCT05677997
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
COVID-19
CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)
There is currently no treatment available for COVID-19, the acute respiratory illness caused by the novel SAR-CoV-2. Convalescent plasma from patients who have recovered from COVID-19 that contains antibodies to the virus is a…
- Trial name
- CONCOR-1 (NCT04348656)
- Testing
- Convalescent plasma
- Where
- 73 sites in United States, Brazil and 1 more
- Volunteers
- 940 people
- Sponsor
- Hamilton Health Sciences Corporation
Vaccination, COVID-19
COVID-19 Vaccine Messaging, Part 1
This study tests different messages about vaccinating against COVID-19 once the vaccine becomes available. Participants are randomized to 1 of 12 arms, with one control arm and one baseline arm.
- Trial name
- NCT04460703
- Testing
- Control message, Baseline message, Personal freedom message
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Yale University
Liver Disease Chronic
COVID-19 Vaccines in Patients With Chronic Liver Disease
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused pandemic since outbreak in 2020.Patients with chronic liver disease (CLD) are at higher risk of mortality and morbidity due to COVID-19.
- Trial name
- NCT05017805
- Testing
- COVID-19 Vaccines
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing 302 Hospital
COVID-19, Cancer
SARS-CoV-2 Specific Immune Response After COVID-19 Vaccination in Cancer Patients
Our study highlights a low degree of neutralization-afforded protection mounted by CoronaVac in cancer patients when compared with healthy volunteers, especially patients who received chemotherapy.
- Trial name
- NCT05313074
- Testing
- CoronaVac vaccine
- Where
- Thailand
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Thailand
Vaccination Refusal, Covid19
Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks
Social technologies for health have already become essential means for providing underserved populations greater social connectedness and increased access to novel health information.
- Conditions
- Vaccination Refusal, Covid19, Heart Diseases
- Trial name
- NCT04779827
- Testing
- Online Social Network and Collective Intelligence Intervention, Independent Control
- Where
- United States
- Volunteers
- 4,476 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
SARS-CoV-2 Vaccination, Liver Transplantation
Effect of SARS-CoV-2 Vaccination in Liver Transplant Recipients
To investigate the variations in the humoral response to vaccines for the prevention of COVID-19 in liver transplant patients based on the type of immunosuppressive therapy adopted (tacrolimus based vs no-tacrolimus based) and…
- Trial name
- NCT05490342
- Testing
- Immunoassay, by ECLIA, for the quantitative in vitro determination of antibodies (including IgG) to the SARS - CoV - 2 spike protein (S) anti-RBD (receptor-binding domain) in serum and plasma samples.
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- University of Rome Tor Vergata
Covid19, SARS-CoV-2 Infection
A Study to Determine Safety and Immunogenicity of the Candidate COVID-19 Vaccine AZD1222 Delivered by Aerosol in Healthy Adult Volunteers
This study will test the COVID-19 vaccine candidate AZD1222 to investigate its safety, tolerability and capability of boosting immune responses both in the blood and the lung when administered to the respiratory tract, in…
- Trial name
- COVAXAER01 (NCT05007275)
- Testing
- 1x10^9 vp AZD1222, 5x10^9 vp AZD1222, 1x10^10 vp AZD1222
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Influenza, Human, SARS-CoV-2 Infection
Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection
The objectives of this study are to understand the long-term consequences of repeated annual influenza vaccination among healthcare workers (HCWs) and to use statistical and mathematical modelling to elucidate the immunological…
- Trial name
- NCT05110911
- Testing
- Influenza vaccination: Fluarix Tetra, Vaxigrip Tetra, Fluquadri, Fluad Quad, Afluia Quad, Flucelvax Quad, SARS-CoV-2 vaccination: Comirnaty or Vaxzevria
- Where
- 6 sites in Australia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
COVID-19 Vaccination, Inflammation
Reactogenicity, Immunogenicity and Inflammatory Response by New COVID-19 Vaccine Platforms
Analysis of humoral antibody and cytokine kinetics after vaccination with either BNT162b2 or ChAdOx1 nCoV-19 vaccine and factors influencing the vaccine immunogenicity
- Conditions
- COVID-19 Vaccination, Inflammation, Vaccine Immune Response, Vaccine Adverse Reaction
- Trial name
- NCT05315856
- Testing
- either BNT162b2 or ChAdOx1 vaccine
- Where
- 3 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- Korea University Guro Hospital
COVID-19 Vaccination
Randomized Trial of COVID-19 Booster Vaccinations (Cobovax Study)
Randomized comparison of 3rd dose with inactivated vaccine (CoronaVac) or mRNA vaccine (Comirnaty) in adults who previously received two doses of CoronaVac (Sinovac) or two doses of BNT162b2 (Comirnaty, BioNTech/Fosun Pharma) at…
- Trial name
- NCT05057169
- Testing
- BNT162b2, CoronaVac
- Where
- Hong Kong
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Influenza, COVID-19
Comparative Immunogenicity of Concomitant vs Sequential mRNA COVID-19 and Influenza Vaccinations
This is a prospective, randomized randomized immunologic study of response to influenza and SARS-CoV-2 vaccination across four of the US Influenza Vaccine Effectiveness (Flu VE) Network study sites.
- Trial name
- NCT06020118
- Testing
- Simultaneous Vaccination (Influenza Vaccine and mRNA COVID booster), Sequential Vaccination (Influenza vaccine then mRNA COVID booster), Sequential Vaccination (mRNA COVID booster then Influenza vaccine)
- Where
- 8 sites in United States
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19
Message Offering Free Round Trip Ride-Share Ride to Pharmacy
This experiment is part of a megastudy with a total of ten experimental conditions and a holdout control condition to which patients will be randomly assigned.
- Trial name
- NCT05612373
- Testing
- COVID Booster text messages
- Where
- United States
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Covid19
Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps
This study will evaluate the effectiveness of utilizing Osteopathic Manipulative Treatment (OMT) procedures as an addition to current mRNA COVID-19 vaccines in terms of enhancing the immune response of participants as assessed by…
- Trial name
- NCT04928456
- Testing
- Osteopathic Manipulative Treatment (OMT)
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Western University of Health Sciences
COVID-19 Pneumonia, Coronavirus Infections
Clinical Trial on Sequential Immunization of Recombinant COVID-19 Vaccine (CHO Cells,NVSI-06-08) and Inactivated COVID-19 Vaccine (Vero Cells) in Population Aged 18 Years and Above
This is randomized, blinded and controlled design. Among the randomly selected subjects who have been vaccinated with two doses of Inactivated COVID-19 vaccine (Vero cell), based on a step-wise approach, the subjects will receive…
- Trial name
- NCT05069129
- Testing
- Recombinant COVID-19 Vaccine (CHO cell，NVSI-06-08), Inactivated COVID-19 vaccine (Vero cells), 3 doses Recombinant COVID-19 Vaccine (CHO cell，NVSI-06-08)
- Where
- United Arab Emirates
- Volunteers
- 1,848 people, healthy volunteers welcome
- Sponsor
- National Vaccine and Serum Institute, China
Hospital Staff, Vaccined Againt COVID-19
Monitoring of the Post-vaccination Immune Response to COVID-19 Among Hospital Staff
Vaccination against COVID-19 is a major public health issue to control the epidemic and reduce the number of severe infections and deaths.
- Trial name
- COVIDIM (NCT04896788)
- Testing
- Monitoring of the immune response
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Covid19, Kidney Transplantation
Monitoring of COVID-19 Vaccine Response in Organ Transplant Patients
Vaccination against SARS CoV-2 appears to be the best strategy today to control the COVID-19 pandemic. The first published studies with Pfizer, Moderna and Astra-Zeneca vaccines show very good vaccine protection in the general…
- Trial name
- COVATRANS (NCT04828460)
- Where
- France
- Volunteers
- 3,500 people
- Sponsor
- University Hospital, Strasbourg, France
Covid19
COVID-19: Safety and Immunogenicity of a Reduced Dose of the BioNTech/Pfizer BNT162b2 Vaccine
This is a randomized phase IV dose-optimization study evaluating the safety and immunogenicity of two doses of COVID-19 mRNA vaccines being authorized in the European Union since December 2020: Vaccine BNT162b2 (Comirnaty®…
- Trial name
- REDU-VAC (NCT04852861)
- Testing
- immunogenicity after first and second dose
- Where
- Belgium
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Sciensano
Vaccine Uptake
Boosting COVID-19 Vaccination Uptake Using Wastewater Surveillance
Vaccinations are among the most successful and critical public health interventions. Despite the enormous protection that vaccines provide to public health, both delays and refusals of vaccines (vaccine hesitancy) are on the…
- Trial name
- NCT06698497
- Testing
- Communication Campaign
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Syracuse University