Clinical trials: Cow's Milk Allergy
Atopy, Atopic Dermatitis Eczema
Breast Milk: Influence of the Micro-transcriptome Profile on Atopy in Children Over Time
This is an observational cohort study of 221 breast-feeding mother-infant dyads delivered at term. The goal of the study is to investigate whether levels of immune-related microRNAs (miRNAs) in maternal breast milk (MBM)…
- Conditions
- Atopy, Atopic Dermatitis Eczema, Wheezing, Food Allergy in Infants
- Trial name
- IMPACT (NCT04017520)
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Cow Milk Protein Sensitivity, Tolerance
Tolerance of Infants With Cow's Milk Protein Allergy to Extensively Hydrolyzed Rice Protein or Casein Infant Formulas
The objective of this double blinded randomized study is to assess the tolerance of two extensively protein hydrolyzed infant formulas, one based on rice protein and the other one on casein, at introduction, and after 3 months of…
- Conditions
- Cow Milk Protein Sensitivity, Tolerance, Growth Failure
- Trial name
- JUNGLO (NCT01909661)
- Testing
- Damira/Celia peptide hydrolyzed casein, Picot riz/Celia rice/Sanutri arroz
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Lactalis
Cow Milk Allergy
Cow Milk Allergy: Evaluation of the Efficacy of a New Thickened Extensively Hydrolyzed Formula in Infants With Confirmed Cow Milk Allergy
The aim of the study is to assess the hypoallergenicity of a new thickened extensively hydrolyzed formula.
- Trial name
- COMETE (NCT02351531)
- Testing
- Extensively Hydrolyzed formula
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 32 people
- Sponsor
- United Pharmaceuticals
Cow's Milk Allergy
Diagnosis of Cow's Milk Protein Allergy
The study will assess the diagnosis of cow's milk protein allergy (CMPA) among infant and children in assiut university children hospital using skin prick test and specific serum IgE as well as their management.
- Trial name
- NCT04330092
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Allergy
Acceptability and Palatability Study of Paediatric Amino Acid Feed
Product acceptability and palatability data from a minimum of 15 participants are required to submit an application to the Advisory Committee on Borderline Substances (ACBS) and the Health Service Executive (HSE) for Ireland for…
- Trial name
- NCT06547346
- Testing
- Alfamino Junior
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Société des Produits Nestlé (SPN)
Cow's Milk Allergy
Epigenetic Features of FoxP3 in Children With Cow's Milk Allergy
Epigenetic mechanisms have been implicated in the pathogenesis of food allergy. The investigators previously demonstrated that tolerance acquisition in children with Immunoglobulin E- (IgE) mediated cow's milk allergy (CMA) is…
- Trial name
- NCT02779881
- Testing
- Extensively hydrolyzed casein formula plus LGG
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
Protein Allergy, Cow's Milk Protein Hypersensitivity
Efficacy of a New Thickened Extensively Hydrolyzed Formula
Cow Milk Allergy (CMA) occurs in 2 to 5 % of all infants. Reflux, regurgitation and vomiting are well recognised symptoms of CMA. The recommended treatment of CMA is an extensive hydrolysate.
- Trial name
- ALLAR (NCT01985607)
- Testing
- new extensively hydrolysed formula, Extensively hydrolysed formula
- Where
- 5 sites in Belgium, Greece and 3 more
- Volunteers
- 72 people
- Sponsor
- United Pharmaceuticals
Allergies Food Milk
Dupilumab and Milk OIT for the Treatment of Cow's Milk Allergy
This is a phase 2, multicenter, randomized, double-blind, parallel group, 2 arm study in approximately 40 subjects aged 4 to 50 years, inclusive, who are allergic to cow's milk.
- Trial name
- NCT04148352
- Testing
- Dupilumab
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Andrew J Long, PharmD
Cow's Milk Allergy
Hypoallergenicity To Substitutive Formulas In Children With Cow's Milk Allergy
The management of children with confirmed cow's milk allergy is based on complete avoidance of cow's milk proteins and leaves the physician with several dietary options, none of which, given the prevalence, spectrum and potential…
- Trial name
- NCT02144428
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Food Allergy
Trophallergen Prick Tests (PT) : Influence of Food Sample Shelf Life on the Reproducibility of PT Results
Prick tests (PT) are the standard skin tests used in the investigation of immediate IgE-mediated food allergies. Their use as a first-line tool in allergological investigations is strongly recommended by the European Academy of…
- Trial name
- TROPHAPRICK (NCT06872996)
- Testing
- Prick-test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Food Allergy
ADP101 for Oral Immunotherapy in Food-Allergic Children and Adults
The purpose of this study is to assess the efficacy and safety of ADP101 in food allergic children and adults.
- Trial name
- NCT04856865
- Testing
- Low dose ADP101, High dose ADP101
- Where
- 15 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alladapt Immunotherapeutics, Inc.
Hypersensitivity, Milk
Early Oral Immunotherapy in Infants With Cow's Milk Protein Allergy
Cow's milk (CM) allergy is the most frequent food allergy in the first years of life, with prevalence rates estimated in the range of 2-3%.
- Trial name
- NCT03586388
- Testing
- Oral immunotherapy protocol
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- IRCCS Burlo Garofolo
Food Allergy
The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults
In Finland, the estimated prevalence of physician-diagnosed food allergy in 1-4 year old children is 9%, and the most common allergen is milk. The overall food allergy has been reported to be 3.7%.
- Trial name
- NCT01822353
- Testing
- Dietary supplement
- Where
- Finland
- Volunteers
- 23 people
- Sponsor
- Helsinki University Central Hospital
Cow's Milk Allergy
Oral Immunotherapy in Cow's Milk Allergy (CMA) in Children : "Petit Lait" Study
Prospective study Main objective: to evaluate the efficiency and the security of two protocols of immunotherapy (raw milk versus heated milk) in a cohort of children with persistent Immunoglobulin E (IgE) mediated CMA (IgE-CMA).
- Trial name
- Petit Lait (NCT02465905)
- Testing
- raw milk, Heated milk
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Dr Flore AMAT
Growth
Evaluation of Safety, Growth, Tolerance and Effects on the Intestinal Fora of a New Milk for Healthy Infants
The purpose of the study is to assess growth and tolerance in new born and infant fed an experimental infant formula with reduced total protein concentration, enriched in alpha-lactalbumin and containing a symbiotic.
- Trial name
- Pétunia (NCT00920166)
- Testing
- Pétunia 1, Regular formula
- Where
- 4 sites in France
- Volunteers
- 97 people
- Sponsor
- Sodilac
Nutrient Deficiency, Eating Behavior
The Effect of Early Childhood Cow's Milk Allergy Elimination Diet on Eating Behaviors, Nutrition, and Growth Status
Cow's milk allergy (CMA) is the most common Food Allergy (FA) in children, and the essential strategy in prevention is avoiding the allergens that may cause potentially life-threatening reactions.
- Conditions
- Nutrient Deficiency, Eating Behavior, Cow Milk Allergy, Growth Disorders
- Trial name
- NCT04576845
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Saglik Bilimleri Universitesi
Colic, Infantile, Milk Allergy, Cow's
Validation Of A Parent Administered Symptom Score For Unsettled Infants (Every Baby is UnIQue)
It's common for infants to be unsettled, especially in the first few months of life. While this is often normal, persistent symptoms can be stressful for families.
- Conditions
- Colic, Infantile, Milk Allergy, Cow's, Gastro Oesophageal Reflux Disease, Atopic Dermatitis (Eczema)
- Trial name
- NCT07121062
- Testing
- Online parent administered questionnaire
- Where
- United Kingdom
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Ig-E Mediated Food Allergy
Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food Allergy
Phase 2b Study of RPT904 as Monotherapy in Participants With IgE-Mediated Food Allergy: This is a Phase 2b randomized, double-blind, placebo-controlled clinical trial evaluating RPT904, a next-generation anti-IgE monoclonal…
- Trial name
- NCT07220811
- Testing
- RPT904
- Where
- 37 sites in United States, Australia and 1 more
- Volunteers
- 100 people
- Sponsor
- RAPT Therapeutics, Inc., a member of the GSK plc group of companies
Food Allergy in Infants, Proctocolitis
Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive...
- Conditions
- Food Allergy in Infants, Proctocolitis, Atopic Dermatitis, Reflux, Gastroesophageal
- Trial name
- NCT04651829
- Testing
- oral food challenge 1, oral food challenge 2
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Armand Trousseau
COW'S MILK ALLERGY
Polymerized Beta-lactoglobulin Comparative Immunoreactivity
Bovine β-lactoglobulin (Bos d 5) is an allergen from cow's milk with relevance to human health. We employed β-lactoglobulin polymerized using microbial transglutaminase as a model of study to identify whether protein…
- Trial name
- ImmuneBLG (NCT01589731)
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil