Clinical trials: Cow Milk Intolerance
Lactose Intolerance
Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters
Cow's milk contains two types of β-casein: A1 and A2. It is evident from human clinical trials that milk with A1 protein produces more hydrogen and symptoms of lactose intolerance.
- Trial name
- NCT05669274
- Testing
- Milk containing A1 and A2 beta-casein, Milk containing only A2 beta-casein
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Milk Intolerance
Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance
There is increasing evidence that a number of people experience moderate milk intolerance characterised by increased gas production, bloating and abdominal cramp, which can neither be attributed to lactose intolerance, nor to…
- Trial name
- NCT03060395
- Testing
- A2 milk 100, A2 milk 150, A2 milk 200
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Reading
Breast Milk Protein Intolerance
Recruiting All Strictly Breast-fed Babies With Blood In Stool
Breast feeding is the most nutritious form of nourishment in infants and is recommended for at least the first four months of life. Breast fed infants may develop milk protein intolerance.
- Trial name
- NCT02745977
- Testing
- Dairy Free Diet
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Winthrop University Hospital
Non-celiac Wheat Sensitivity
Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients
In the last few years a new clinical entity has emerged which includes patients who consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease (CD) or…
- Trial name
- NCT03008252
- Testing
- Lactose breath test, DBPC cow's milk protein challenge
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Palermo
Dairy Intolerance
Comparing the Digestion of Milk With Different Beta-casein Protein Content by Dairy Intolerant Persons
Persons with dairy intolerance may experience cramps/abdominal pain, bloating, flatulence, acute diarrhea, or fecal urgency when they ingest excessive amounts of lactose.
- Trial name
- NCT03713346
- Testing
- Lactose free milk, Jersey milk, High A1 β-casein milk
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Purdue University
Premature; Infant, Light-for-dates
Re-feeding Gastric Residuals in Preterm Infants
The purpose of this study is to determine whether re-feeding of gastric residuals reduces the time needed to establish full enteral feedings in premature infants.
- Trial name
- NCT01420263
- Testing
- Re-feeding residuals, Fresh Feeding Breastmilk or Formula only
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Alabama at Birmingham
Cow's Milk Protein Allergy Protein Intolerance Failure to Thrive
Nutritional Evaluation of Infants Receiving Amino Acid-Based Formula
This study aims to evaluate the growth parameters and nutritional status of infants who are receiving amino acid-based formula due to cow's milk protein allergy or other medical indications.
- Trial name
- NCT07174999
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Assiut University
Lactose Intolerance
Effects Comparison of A1 and A2 Milk on Gastrointestinal Physiology, Symptoms and Cognitive Behavior
This is a single-site, double-blinded, randomized, controlled, 2X2 cross-over study aiming to compare effects of milk containing only A2 type beta casein versus milk containing both A1 and A2 beta casein proteins on the…
- Trial name
- NCT02406469
- Testing
- Oral consumption milk Tetra Pak
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Lactose Intolerance
Effects of Raw Versus Other Milk Sources on Lactose Digestion
The purpose of this small, short pilot study is to determine the feasibility (e.g., recruitment, dose acceptance, retention) of a future longer trial comparing the effects of different types of milk (raw milk, cow's milk…
- Trial name
- NCT01129791
- Testing
- Raw Milk, Pasteurized Milk, Non-dairy milk
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stanford University
Low Milk Supply, Pre-diabetes
Metformin to Augment Low Milk Supply (MALMS) Study
Most new mothers in the United States will start off breastfeeding. For some mothers, despite following best practices, they are not able to meet their breastfeeding goals due to unexplained low milk supply.
- Conditions
- Low Milk Supply, Pre-diabetes, Insulin Resistance, Suppressed Lactation
- Trial name
- MALMS (NCT02179788)
- Testing
- Standard care, Metformin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Lactose Intolerance
Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance
RP-G28 is being investigated for treatment of moderate to severe lactose intolerance and its potential to improve the tolerance of lactose (dairy products).
- Trial name
- NCT02673749
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Cow's Milk Allergy, Intolerance to Extensively Hydrolyzed Formulas
Evaluation of Fatty Acid Levels and Growth in Infants Fed Amino Acid Based (AA) Formulas
This clinical trial will compare the amount of fatty acids in whole blood of babies fed one of two study formulas for 4 months.
- Conditions
- Cow's Milk Allergy, Intolerance to Extensively Hydrolyzed Formulas, Intolerance to Breast Milk
- Trial name
- NCT01470768
- Testing
- Amino Acid-based Formula with high DHA and ARA, Amino Acid-based Formula with lower DHA and ARA
- Where
- United Kingdom
- Sponsor
- Mead Johnson Nutrition
Feeding; Difficult, Newborn
Source of Human Milk Fortifier and Intestinal Oxygenation in Preterm Infants <30 Weeks Gestation
Preterm infants require higher nutritional intakes during the neonatal phase than they do at any other stage of their development. Standard volumes of human milk alone do not offer sufficient nourishment to these infants.
- Trial name
- NCT06336668
- Testing
- Human milk-based HMF
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Growth, Necrotizing Enterocolitis
Bovine Colostrum as a Fortifier Added to Human Milk for Preterm Infants
Very preterm infants (<32 weeks gestation) with very low birth weight (VLBW, <1500 g) show immaturity of organs and have high nutrient requirements forgrowth and development.
- Conditions
- Growth, Necrotizing Enterocolitis, Late-Onset Sepsis, Feeding Intolerance
- Trial name
- FortiColos (NCT03537365)
- Testing
- Bovine Colostrum (BC) / intervention group, FM85 / control group
- Where
- 7 sites in Denmark
- Volunteers
- 252 people
- Sponsor
- Per Torp Sangild
Pre-diabetes
Effects of Milk Powder Intervention on Blood Glucose Control and Fluctuation in Middle-aged and Elderly People With Pre-diabetes
This study aims to conduct a 8-week intervention involving one formula milk powder for middle-aged and elderly individuals with pre-diabetes, assessing its impact on blood glucose control and fluctuations in comparison to…
- Trial name
- NCT06863766
- Testing
- fortified formula milk powder group, regular milk powder group
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Huilian Zhu
Lactose Malabsorption, Cardiovascular Disease
Whole Milk Intake and Cardio-metabolic Risk Factors
Milk is the source of high-quality protein, calcium, and other vitamins and minerals. Epidemiologic studies have linked high consumption of milk with risk of metabolic syndrome, T2DM, hypertension and obesity, which are…
- Trial name
- NCT02798718
- Testing
- full-fat milk
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Feeding Intolerance, Necrotizing Enterocolitis
Bovine Colostrum as a Human Milk Fortifier for Preterm Infants
Very preterm infants (<32 weeks gestation) show the immaturity of organs and have high nutrient requirements for growth and development.
- Conditions
- Feeding Intolerance, Necrotizing Enterocolitis, Postnatal Growth, Late-Onset Neonatal Sepsis
- Trial name
- FortiColos-Ⅱ (NCT03822104)
- Testing
- Bovine Colostrum, FM85
- Where
- 2 sites in China
- Volunteers
- 139 people
- Sponsor
- Per Torp Sangild
Gastrointestinal Diseases, Cow's Milk Intolerance
Goat Milk Infant Formula Comfort Study
In this study, the investigators aim to assess that infants with mild symptoms have significantly less (severe) symptoms after 14 days goat milk-based formula use compared to infants using cow's milk-based formula supplemented…
- Trial name
- NCT06301139
- Testing
- Goat milk-based infant formula, Cow's milk-based infant formula with probiotic drops
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ausnutria Hyproca B.V.
Human Milk Fortification, Very Low Birth Weight Baby
Enrichment of Human Milk With Human and Bovine Milk-based Fortifiers for Very Preterm Infants: a Meta-analysis
Research has shown that provision of mother's milk is the optimal way to feed very low birthweight (VLBW) infants. Many infants will require a supplement to mother's milk, pasteurized donor human milk (PDHM) compared to preterm…
- Conditions
- Human Milk Fortification, Very Low Birth Weight Baby, Human Milk Nutrition, Human Milk Feeding
- Trial name
- NCT06870318
- Testing
- No intervention; Observational study
- Where
- 2 sites in Canada, Sweden
- Volunteers
- 355 people
- Sponsor
- The Hospital for Sick Children
Milk Intolerance
Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyzed A1 Milk
The aim of this study is to reveal how different forms of milk casein, lactose and moderate breakdown of proteins affect the symptoms that may arise from milk and markers of inflammation in volunteers receiving symptoms from…
- Trial name
- NCT05305391
- Testing
- Dietary intervention
- Where
- Finland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Turku