Clinical trials: Cramps
Neoplasms, Head and Neck, Trismus
Manual Therapy and Use of the Dynasplint for Trismus in Patients With Head and Neck Cancer
The objectives of this pilot study are to determine the effectiveness of a manual therapy (MT) protocol plus the use of a dynamic jaw opening device on the maximal interincisor distance; on trismus symptoms; on pain-disability…
- Trial name
- NCT03178110
- Testing
- Physical therapy and dynasplint
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Third Molar Extraction
Fixed-dose Combination of Etoricoxib + Cyclobenzaprine for Pain Relief After Third Molar Extraction in Brazil
Etoricoxib and cyclobenzaprine hydrochloride are active pharmaceutical ingredients (APIs) already registered in the country as mono-drugs.
- Trial name
- BENCOX (NCT05683574)
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Oral Cancer
Effects of Mouth-opening Training on the Maximum Interincisal Opening
PURPOSE:The purpose of the study was to investigate the effect of mouth-opening training with follow-up telephone calls for reducing postoperative trismus in patients with oral cancer.
- Trial name
- NCT03875118
- Testing
- The mouth-opening training with follow-up telephone calls program, The mouth-opening training without follow-up telephone calls program
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Critical Illness, Asthma
Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial
Despite few scientific evidence that could support the use of ketamine in adult patients undergoing acute bronchospasm requiring mechanical ventilation (MV), ketamine is largely employed in this setting.
- Conditions
- Critical Illness, Asthma, Bronchospasm
- Trial name
- MACANUDO (NCT03000413)
- Testing
- Ketamine, Fentanyl
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Postoperative Morbidity
Effects of Hyaluronic Acid Complex and Dexamethasone on Pain, Swelling, and Trismus After Mandibular Third Molar Surgery
This study aimed to comparatively evaluate the effects of a hyaluronic acid complex and dexamethasone on postoperative pain, swelling, and trismus following mandibular third molar surgery, compared with a control group.
- Trial name
- NCT07853196
- Testing
- Hyaluronic Acid Complex, Dexamethasone, Absorbable Hemostatic Gelatin Sponge (SPONGOSTAN™ Dental)
- Where
- Cyprus
- Volunteers
- 45 people
- Sponsor
- Cyprus Health and Social Sciences University
Blepharospasm, Hemifacial Spasm
Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm
A triple-masked placebo-controlled trial assessing the efficacy and safety of pretarsal versus preseptal botulinum toxin for patients with eyelid spasm.
- Conditions
- Blepharospasm, Hemifacial Spasm, Botulinum Toxins, Type A
- Trial name
- NCT03508882
- Testing
- Botulinum Toxin Type A 100Unit/Vial (Product), Saline Solution for Injection
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Cervical Spasm, Radiotherapy Side Effect
Effect of Type-A Botulinum Toxin in the Post-radiosurgical Neck Contractures
The main objective of the study is to estimate the efficiency and to determine the optimal dose of Botulinum toxin A, administered by intramuscular way in cervical spasms after radiotherapy, as well as the optimal sites for these…
- Conditions
- Cervical Spasm, Radiotherapy Side Effect, Botulinum Toxin
- Trial name
- NCT02986880
- Testing
- Botulinum toxin A
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Hopital Foch
Irritable Bowel Syndrome, Digestive System Diseases
Efficacy of a Multi-strain Probiotic in the Treatment of Irritable Bowel Syndrome (IBS)
The Canadian College of Naturopathic Medicine is conducting a research study on Irritable Bowel Syndrome (IBS), a common condition in North America.
- Conditions
- Irritable Bowel Syndrome, Digestive System Diseases, Colonic Diseases, Functional, Colitis, Mucous
- Trial name
- NCT01176227
- Testing
- Kyodophilus multi-strain probiotic capsules
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Coronary Vasospasm
The Effect of Nebivolol in Hypertensive Patients With Coronary Arterial Spasm
The correlation between endothelial dysfunction and the risk of coronary heart disease is well known through previous studies. The degradation of the function of nitric oxide acting on the endothelium of blood vessels is mainly…
- Trial name
- NCT03930433
- Testing
- Nebivolol, Diltiazem, Nebivolol+Diltiazem
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Korea University Anam Hospital
Bladder Spasm, Malignant Neoplasm
Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer
This pilot phase I trial studies the side effects and best dose of curcumin when given together with piperine (piperine extract [standardized]) in reducing inflammation for ureteral stent-induced symptoms in patients with cancer.
- Conditions
- Bladder Spasm, Malignant Neoplasm, Pain, Urinary Urgency
- Trial name
- NCT02598726
- Testing
- Curcumin, Laboratory Biomarker Analysis, Piperine Extract (Standardized)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Trismus
Prevention of Trismus During Radiotherapy and Quality of Life in Head and Neck Cancer Patients
Trismus (limited jaw mobility), can occur in patients undergoing radiotherapy to specific areas of the head or neck. Trismus leads to difficulty in eating, swallowing, speech and general mouth hygiene, which all have negative…
- Trial name
- NCT01354548
- Testing
- TheraBite® Jaw Motion Rehabilitation System™
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- University Hospital, Linkoeping
Infantile Spasm
A Novel Approach to Infantile Spasms
This study proposes to assess the efficacy of Cosyntropin Injectable Suspension, 1 mg/mL compared to vigabatrin. Additionally, this study proposes to determine efficacy of combination therapy of Cosyntropin Injectable Suspension…
- Trial name
- NCT03347526
- Testing
- Cosyntropin Injectable Suspension, 1 mg/mL, Cosyntropin Injectable Suspension 1 MG/ML + vigabatrin, Vigabatrin
- Where
- 14 sites in United States
- Volunteers
- 394 people
- Sponsor
- University of Colorado, Denver
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscular Diseases
The Effect of Statin Medications on Muscle Performance (The STOMP Study)
Statins are a group of medications that are used to lower cholesterol levels. Although serious side effects are rare, some people taking statins experience muscle pain or weakness.
- Trial name
- STOMP (NCT00609063)
- Testing
- Atorvastatin
- Where
- 3 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Postoperative Pain, Trismus
Effect of CGF on Short Term Clinical Outcomes After Partially Impacted Mandibular Third Molar Surgery
The aim of this study was to evaluate the effectiveness of concentrated growth factor (CGF) on soft tissue healing and postoperative side effects following third molar surgery.
- Conditions
- Postoperative Pain, Trismus, Edema
- Trial name
- CGF (NCT03913884)
- Testing
- Concentrated growth factor, Non-Concentrated growth factor Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ege University
Vitamin d Deficiency
Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.
Vitamin D (Vitamin D) deficiency is very common. We recently showed that 97% of 204 patients admitted to Truman Medical Center were Vitamin D deficient (<30 ng/ml).
- Trial name
- NCT02138591
- Testing
- Blood draw pre-operatively, Blood draw post-operative Day 1, Blood draw post-operative Day 2
- Where
- United States
- Sponsor
- University of Missouri, Kansas City
Hyperactive Delirium
MindfulGarden in Treatment of Hyperactive Delirium in a Hospital Setting
This pilot study is designed to address feasibility for a larger randomized control clinical study that will determine the efficacy of exposure to the MindfulGarden - an interactive digital technology - in reducing hyperactive…
- Trial name
- NCT03621228
- Testing
- MindfulGarden
- Volunteers
- 24 people
- Sponsor
- Simon Fraser University
Spasm
Development and Evaluation of a Portable Wedge Device for Calf Stretching to Alleviate Strain and Spasms
This research aimed to contribute valuable insights into the potential benefits of incorporating the portable wedge device into preventive or therapeutic interventions for calf-related musculoskeletal issues.
- Trial name
- NCT06441253
- Testing
- Deep Friction massage, Therapeutic exercises
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Superior University
Postoperative Trismus
Maitland Mobilization Versus Therapeutic Ultrasound on Trismus Following Third Molar Surgery
This study aims to compare the effect of Maitland mobilization and therapeutic ultrasound on trismus (limited mouth opening) following third molar (wisdom tooth) surgery.
- Trial name
- NCT07575100
- Testing
- Maitland Joint Mobilization, Therapeutic Ultrasound group, Control group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Trismus
Effectiveness of Serratiopeptidase After Mandibular Third Molar Surgery
This randomized controlled trial was conducted to compare the effect of serratiopeptidase versus no intervention on postoperative mouth opening, swelling, and trismus following surgical removal of mesioangular mandibular third…
- Trial name
- NCT07543146
- Testing
- Serratiopeptidase, Standard Postoperative Care
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Sharif Medical Research Center
Attention Deficit Disorder, Attention Deficit Disorder (ADD)
The Primary Objective of This Study is to Determine Whether Positively Framed Information (PFI) on Side Effects, Compared to Negatively Framed and Extensive Information (NFI) Can Reduce the Number and Severity of Reported Adverse Events Caused by ADHD Medication in Children Aged 7 to 17 Years.
The goal of this randomized controlled care evaluation is to determine whether positively framed and concise information (PFI), compared to negatively framed and extensive information (NFI) about adverse events can reduce the…
- Conditions
- Attention Deficit Disorder, Attention Deficit Disorder (ADD), Attention Deficit Disorder with Hyperactivity, ADHD
- Trial name
- NOVA (NCT06797570)
- Testing
- Communication Strategy for Side Effect Counseling in ADHD Treatment
- Volunteers
- 130 people
- Sponsor
- St. Antonius Hospital