Clinical trials: Cranial Aneurysm
Intracranial Aneurysm
Safety and Performance of the Neuroform Atlas™ Stent System
The objective of this retrospective study is to describe in real-life settings the clinical practice, utilization and the treated population outcomes at 1-year (12-16 months) follow-up at selected, representative centers in…
- Trial name
- ATLAS-FR (NCT04162483)
- Testing
- Neuroform Atlas Stent System
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Stryker Neurovascular
Intracranial Arterial Aneurysm
Safety and Efficacy of the Surpass Evolve Flow Diverter in Treating Intracranial Aneurysms
Safety and Efficacy of the Surpass Evolve Flow Diverter in Treating Intracranial Aneurysms
- Trial name
- NCT06731946
- Testing
- Flow diverting
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Yibin Fang
Brain Aneurysm
Aneurysm Genetic Risk in Patients With QIB Changes
Intracranial aneurysm rupture is a leading cause of hemorrhagic strokes which carry high mortality and disability rates as well as high healthcare costs.
- Trial name
- AnGen (NCT05317169)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Aneurysm, Cerebral
Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients
Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid haemorrhage and neurologic complications.
- Trial name
- NCT03823482
- Testing
- Lidocaine
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Clinical Hospital Centre Zagreb
Brain Aneurysm
Trial on Endovascular Aneurysm Management
The management of patients with unruptured aneurysms is controversial. Patients with unruptured aneurysms may suffer intracranial hemorrhage, but the incidence of this event is still debated.
- Trial name
- TEAM (NCT00537134)
- Testing
- Embolization, coiling
- Where
- 9 sites in United States, Canada and 2 more
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cerebral Aneurysm Unruptured, Cerebral Aneurysm
Parent Artery Reconstruction for Small Unruptured Cerebral Aneurusms Using Flow DiverTers: a Multicenter Randomized Trial(PARAT-MT)
A prospective, multicenter, randomized controlled clinical trial with open-label treatment and blinded endpoint assessment.
- Trial name
- NCT06600997
- Testing
- Flow Diversion for Endovascular Treatment of Intracranial Aneurysms, Conventional endovascular therapy (stent-assisted coiling, balloon-assisted coiling, or coiling) for endovascular treatment of intracranial aneurysms
- Volunteers
- 1,008 people
- Sponsor
- Changhai Hospital
Intracranial Aneurysm
Flow Diverter Stent for Endovascular Treatment of Unruptured Saccular Wide-necked Intracranial Aneurysms
Unruptured saccular intracranial aneurysms larger than 7 mm can be treated with endovascular occlusion using detachable coils, with or without expendable stent assistance.
- Trial name
- EVIDENCE (NCT01811134)
- Testing
- PIPELINE flow diverter stent, Coils, with or without expendable stent
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Hospices Civils de Lyon
Unruptured Cerebral Aneurysm
Impact of Genetic Polymorphism on Propofol Requirement and Recovery for Total Intravenous Anesthesia for Clipping of Unruptured Cerebral Aneurysm in Korean Population
In neurosurgical anesthesia, propofol based total intravenous anesthesia (TIVA) is frequently used due to brain relaxation and less effect on electrophysiologic monitoring.
- Trial name
- NCT02700126
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Yonsei University
Intracranial Aneurysm
Nomogram for Predicting In-stent Stenosis After Pipeline Embolization Device Treatment in Patients With Intracranial Aneurysm
Intracranial aneurysms (IAs) are the primary cause of non-traumatic subarachnoid hemorrhage with high morbidity and mortality. Flow diverters, such as pipeline embolization devices (PEDs), are among the most effective methods for…
- Trial name
- PED-ISS (NCT06715930)
- Testing
- Interventional treatment
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tiantan Hospital
Brain Aneurysm
Aneurysm Wall Histology Registry
The purpose of this prospective registry is to determine if patients harboring intracranial aneurysms have any predictive markers between aneurysm wall tissue, cerebrospinal fluid and blood plasma.
- Trial name
- NCT01444664
- Testing
- Surgical Clipping of Aneurysm
- Where
- 10 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Intracranial Aneurysm
Contrast-enhanced Magnetic Resonance Angiography Investigation of Intracranial Aneurysms and Prospective Study of Risk Factors
This is a prospective observational registry with intent to detect the prevalence of intracranial aneurysms with contrast-enhanced MR angiography (CE-MRA) at 1.5T, and to determine the risk factors such as high blood pressure and…
- Trial name
- EIIA (NCT00997698)
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Second Military Medical University
Intracranial Aneurysm, Cerebrovascular Disease
Aspirin Treatment for Small Unruptured InTracranial Aneurysms With Ischemic cereBrovascuLar diseasE
The management of small unruptured intracranial aneurysms (UIA) with ischemic cerebrovascular disease (ICVD) has been a very controversial topic in neurosurgery.
- Trial name
- AT-SUITABLE (NCT05907902)
- Testing
- Aspirin Enteric-coated Tablets
- Where
- 2 sites in China
- Volunteers
- 824 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
A Feasibility Study to Evaluate the Safety and Effectiveness of Implantation of Flowise Cerebral Flow Diverter (Flowise)
The purpose of this study is to evaluate the safety and short-term effectiveness of implantation of 'Flowise Cerebral Flow Diverter' for the treatment of unruptured wide-necked cerebral aneurysm in the internal carotid artery.
- Trial name
- NCT02609867
- Testing
- Flowise Cerebral Flow Diverter
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Aneurysm, Aneurysm, Intracranial
Safety and Efficacy of Endovascular Treatment of Intracranial Aneurysms With Surpass Elite With GUARDian Flow Diverter (GUARD)
The objective of the Safety and Efficacy of Endovascular Treatment of Intracranial Aneurysms with Surpass Elite with GUARDian Flow Diverter (GUARD) trial is to evaluate the safety and efficacy of the Surpass Elite with Guardian…
- Trial name
- GUARD (NCT06872684)
- Testing
- Surpass Elite with Guardian Flow Diverter System
- Where
- 20 sites in United States
- Volunteers
- 183 people
- Sponsor
- Stryker Neurovascular
Aneurysm, Intracranial Aneurysm
Appraising the Embolization of Aneurysms Using Balt Optima™ Coil System (APPLY Study)
In recent years, many developments have been made to the tools and techniques used to treat IAs via endovascular intervention. Specifically, to the detachable coils themselves.
- Conditions
- Aneurysm, Intracranial Aneurysm, Ruptured Aneurysm, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- APPLY (NCT04499508)
- Testing
- Optima Coil System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vascular Neurology of Southern California Inc.
Unruptured Intracranial Aneurysm, Headache
Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Postoperative Headache Following Stent-Assisted Coiling of Unruptured Intracranial Aneurysms
The goal of this clinical trial is to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in reducing postoperative headache among adults undergoing stent-assisted coiling for unruptured…
- Conditions
- Unruptured Intracranial Aneurysm, Headache, Vagus Nerve Stimulations
- Trial name
- IMPACT-HT (NCT07479082)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Safety Study of Intracranial Support Catheter and Guide Catheter for Stent-Assisted Embolization in the Treatment of Intracranial Aneurysms
The purpose of this study is to evaluate the safety differences between intracranial support catheter and guide catheter for stent-assisted embolization in the treatment of unruptured intracranial aneurysms in the anterior…
- Trial name
- SAFETI (NCT05524285)
- Testing
- Intracranial Support Catheter, Guide Catheter
- Where
- 9 sites in China
- Volunteers
- 264 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Subarachnoid Hemorrhage, Hypertension
Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage
This study is designed to assess how rapidly and how safely Clevidipine can be used to control high Blood Pressure in patients with subarachnoid hemorrhage which is a type of brain bleed that happens because of a weak balloon…
- Trial name
- CLASH (NCT00978822)
- Testing
- Clevidipine butyrate injectable emulsion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Henry Ford Health System
Intracranial Arterial Aneurysm
Analysis Of Intracranial Artery Lesions Using 2-D/3D Phase Contrast MR
Using phase contrast MR Angiography with NOVA® Software, this study intends to identify,evaluate and map intracranial aneurysm development as well as develope a predicator for future morphological changes of aneurysms and…
- Trial name
- NCT00710281
- Testing
- Additional scan time on standard MR angiography
- Where
- United States
- Sponsor
- Lahey Clinic
Small Intracranial Aneurysms
COAST: Coiling of Aneurysms Smaller Than 5mm With Hypersoft® and Hydrogel Coils
This is a prospective, single-arm, multi-center post-marketing Study. The Study will commence as a single phase, with an optional second phase to follow at the discretion of the sponsor.
- Trial name
- COAST (NCT02259504)
- Testing
- PHASE 1- HyperSoft® 3D and HyperSoft® Helical Coils, PHASE 2 - HydroSoft® 3D and HydroSoft® Helical Coils
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Medical University of South Carolina