Clinical trials: Cranial Nerve Palsy
Palsy Supranuclear, Supranuclear Palsy, Progressive
Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP).
- Trial name
- NCT04468932
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Bell Palsy
Mime Therapy With and Without Neural Mobilization in Bell's Palsy.
To determine the Effects of Mime Therapy with and without Neural Mobilization on Facial symmetry, Synkinesis and Functional abilities in Patients with Bell's Palsy.
- Trial name
- NCT06459830
- Testing
- Mime Therapy with Neural Mobilization
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Vocal Cord Paralysis
Dynamic Laryngeal Opening for Bilateral Vocal Fold Paralysis by an Implanted Stimulator
People who had paralysis of the vocal cords are often prevented from breathing by this problem because the cords will not open, and the patients have to wear a tracheostomy (neck breathing tube) to bypass this airway obstruction.
- Trial name
- NCT00845442
- Testing
- pacemaker
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University Hospitals Cleveland Medical Center
Goiter
Outcomes of Different Thyroid Resections for Multinodular Non-toxic Goiter
The aim of this three-arm randomized study was to evaluate results of different thyroid resection modes among patients with bilateral multinodular non-toxic goiter, with special emphasis put on recurrence rate and morbidity rate…
- Trial name
- NCT00946894
- Testing
- Total thyroidectomy, Dunhill operation, Bilateral subtotal thyroidectomy
- Where
- Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Bell Palsy
Effects of Massage Therapy and Facial PNF in Early Bell's Palsy
Effects of Massage therapy and Facial PNF in early Bell's palsy
- Trial name
- NCT05679752
- Testing
- Facial PNF technique, Massage therapy
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Neuro Counsel Hospital, Pakistan
Oculomotor Nerve Palsy
Effects of Ocular Electroacupuncture on Oculomotor Nerve Palsy
The purpose of the study is to testify the efficacy of treating oculomotor nerve palsy with ocular electroacupuncture or ocular acupuncture, and to compare the efficacy between these two interventions.
- Trial name
- NCT03099447
- Testing
- ocular electroacupuncture, ocular acupuncture
- Where
- China
- Volunteers
- 177 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Parkinson Disease, Progressive Supranuclear Palsy
Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes
Parkinson's disease (PD) is the most common degenerative Parkinson's syndrome and is linked, among other things, to the excessive accumulation of an abnormally aggregating protein, alpha-synuclein.
- Trial name
- SODIPARK (NCT06155942)
- Testing
- 7 Tesla MRI
- Where
- 6 sites in France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Parkinson Disease, Multiple System Atrophy
Research of Biomarkers in Parkinson Disease
The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to determine gene expression profiles specific for genetic and idiopathic Parkinson's disease (PD) patients.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Huntington Disease
- Trial name
- Genepark (NCT00465790)
- Where
- 5 sites in Croatia, France and 2 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease, Progressive Supranuclear Palsy
Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL)
To perform a prospective cohort study with [(18)F]fluoroethoxybenzovesamicol (FEOBV) brain PET at baseline and 2-year follow-up in PD subjects at risk of conversion to non-episodic and episodic (falls and FoG) PIGD motor features…
- Trial name
- NCT05459753
- Testing
- (18)F]fluoroethoxybenzovesamicol ([(18)F (FEOBV) PET, Dihydrotetrabenazine (DTBZ) PET
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Mitochondrial Diseases
A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease
A long-term extension study to assess the safety, tolerability and efficacy of cysteamine bitartrate delayed-release capsules (RP103) in children with inherited mitochondrial diseases who previously enrolled into study…
- Trial name
- NCT02473445
- Testing
- Cysteamine Bitartrate
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Amgen
Unilateral Vocal Cord Paralysis
Surgery for Vocal Cord Paralysis
Unilateral vocal fold paralysis (UVFP) is caused by injury to the nerve to the affected vocal fold. The injury to the vocal fold makes the affected person's voice sound "breathy".
- Trial name
- NCT00064571
- Testing
- vocal fold medialization, vocal fold reinnervation
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Corticobasal Syndrome, Progressive Supranuclear Palsy
Diagnosing Frontotemporal Lobar Degeneration
To establish diagnostic tools to make an accurate clinical and pathological diagnosis of patients with clinical FTLD syndromes
- Conditions
- Corticobasal Syndrome, Progressive Supranuclear Palsy, Behavioral Variant Frontotemporal Dementia, Semantic Dementia
- Trial name
- NCT02964637
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Vascular Parkinsonism, Drug-induced Parkinsonism
AI-Enhanced Optimization of Acute Levodopa Challenge Test
A quantitative evaluation method was developed for Parkinson's disease and other atypical parkinonism by integrating an innovative motor paradigm with perception technologies and artificial intelligence.
- Conditions
- Vascular Parkinsonism, Drug-induced Parkinsonism, Corticobasal Degeneration (CBD), Parkinson Disease (PD)
- Trial name
- NCT06949865
- Testing
- video recording
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Bell's Palsy
Bell's Palsy With a Duration of Greater Than 8 Weeks Treated With Multiwave Locked System Intervention
OBJECTIVE: To determine whether photobiomodulation therapy by class IV Multiwave Locked System laser treatment could relieve symptoms in patients with Bell's palsy with a duration of greater than 8 weeks.
- Trial name
- NCT05846217
- Testing
- Multiwave Locked System
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Tongren Hospital
Progressive Supranuclear Palsy, Fall
Cerebellar rTMS Theta Burst for Postural Instability in Progressive Supranuclear Palsy
Objective of the study: To test the efficacy of theta burst cerebellar stimulation on postural instability in progressive supranuclear palsy using a cross-over design and wearing sensors technology Design: Twenty probable PSP…
- Conditions
- Progressive Supranuclear Palsy, Fall, Gait, Rigid, Parkinsonism
- Trial name
- CerTI-PSP (NCT04222218)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Europea di Ricerca Biomedica Ferb Onlus
Bell Palsy
Two Electroacupuncture Waveforms for Different Severity Groups of Bell Palsy
Bell palsy (BP) is the most common cause of acute facial palsy, which leads to functional and esthetic disturbances for patients and results in a lowered quality of life.
- Trial name
- NCT06063954
- Testing
- electroacupuncture
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Paralysis, Unilateral, Vocal Cord
APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study
This is a prospective, 2-part, multi-center, open-label, non-randomized clinical trial to assess safety and effectiveness of APrevent® VOIS Implants for the treatment of patients with Unilateral Vocal Fold Paralysis (UVFP).
- Trial name
- NCT05119842
- Testing
- APrevent® VOIS-Implant
- Where
- 7 sites in United States, Austria and 1 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- APrevent Biotech GmbH
Progressive Supranuclear Palsy
Alpha-lipoic Acid/L-acetyl Carnitine for Progressive Supranuclear Palsy
Studies have shown that alpha-lipoic acid and L-acetyl carnitine may have some neuroprotective activities and it is hoped that they could be helpful for people with neurodegenerative illnesses such as progressive supranuclear…
- Trial name
- NCT01537549
- Testing
- alpha-lipoic acid and L-acetyl carnitine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Weill Medical College of Cornell University
Vocal Cord Paralysis
Bilateral Laryngeal Paralysis Reinnervation
Bilateral laryngeal reinnervation induces a rise in laryngeal resistance and speech alteration. The aim of this study is to propose laryngeal reinnervation by a phrenic nerve root to patients with bilateral laryngeal paralysis.
- Trial name
- NCT00213616
- Testing
- surgical reinnervation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Rouen
Dysphonia, Unilateral Vocal Cord Paralysis
The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy
Evaluate if adding expiratory muscle strength training to traditional voice therapy for individuals with dysphonia due to glottal insufficiency improves maximal expiratory pressure, acoustic and aerodynamic measures (i.e.
- Trial name
- NCT03692494
- Testing
- Standard of care voice therapy, Expiratory muscle strength training (EMST)
- Where
- United States
- Sponsor
- University of Miami