Clinical trials: Cranioplasty
Cranioplasty, Sonolucent Cranioplasty
Transcranial Ultrasound Via Sonolucent Cranioplasty
Transcranial Ultrasound via Sonolucent Cranioplasty is a prospective, single arm, observational, open label (non-blinded) study to collect real world evidence on the use of transcranial ultrasound via sonolucent cranioplasty.
- Conditions
- Cranioplasty, Sonolucent Cranioplasty, Reconstructive Cranioplasty
- Trial name
- NCT06097845
- Testing
- Transcranial Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Brain Injury, Neuropsychological Deficits
Cognitive Functions in Severe Acquired Brain Injury After Cranioplasty
Cranioplasty is the main reconstructive neurosurgical procedure, performed in approximately 80% of patients who have previously undergone demolitive surgeries in an emergency setting, particularly in the case of decompressive…
- Conditions
- Brain Injury, Neuropsychological Deficits, Cranioplasty, Cognitive Deficit Following Brain Lesions
- Trial name
- NeC (NCT06895109)
- Testing
- improvement of cognitive functions and psychological aspects
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Pain
Regional Scalp Block Versus IV Parecoxib for Post-operative Cranioplasty Surgery Pain: A Comparison of Pain Score.
To compare the post cranioplasty pain score using scalp block versus conventional analgesia using IV Parecoxib and requirement of morphine between two groups as rescue analgesia
- Trial name
- NCT05442411
- Testing
- Ropivacaine 0.75% Injectable Solution
- Where
- Malaysia
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Cranioplasty, Postoperative Complications
Risk Factors for Complications After Cranioplasty
Cranial defects often result from brain injuries, hemorrhages, strokes, or brain tumors. These conditions can increase pressure inside the skull, and if left untreated, may lead to dangerous complications like brain herniation.
- Conditions
- Cranioplasty, Postoperative Complications, Risk Assessment
- Trial name
- NCT06740773
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Qilu Hospital of Shandong University
Brain Injuries, Hematoma of Head
Comparison of Cranioplasty With PEEK and Titanium
Decompressive craniectomy is suggested as an effective surgical intervention for patients with high intracranial pressure. Recently, various customized artificial materials are increasingly employed, e.g., titanium and…
- Conditions
- Brain Injuries, Hematoma of Head, Skull Defect
- Trial name
- NCT04707404
- Testing
- Cranioplasty
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Skull Defect
Prospective Observational Study on Comprehensive Effects of PEEK Cranioplasty and Titanium Cranioplasty After DC（RECEPT-DC）
The objective of this trial is to scientifically evaluate the efficacy of PEEK cranioplasty and titanium cranioplasty. The primary objective is to compare the rate of implant failure (defined as infection, implant exposure and…
- Trial name
- NCT05416684
- Where
- China
- Volunteers
- 358 people
- Sponsor
- RenJi Hospital
Cranioplasty, Craniotomy
Effectiveness of 3D Bone Matrix in Cranioplasty
The objective of this clinical trial is to evaluate the effectiveness of a 3D bone scaffold in relation to a scaffold formed by PCL + β-TCP (polycaprolactone and beta-tricalcium phosphate), compared to the use of PMMA (polymethyl…
- Conditions
- Cranioplasty, Craniotomy, Craniotomy Clipping, Craniotomy Surgery
- Trial name
- OSTEOPRINTCR (NCT06792864)
- Testing
- OsteoprintCR, SMAR SET GMV Endurance Gentamicin
- Where
- Chile
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universidad Austral de Chile
Stroke, Head Trauma
Computer Based Algorithm for Patient Specific Implants for Cranioplasty in Patients With Skull Defects
Patients with skull defects after craniotomy for example tumor resection, head trauma, stroke, need a reimplantation of the bone afterwards.
- Trial name
- CAPSID (NCT02828306)
- Testing
- Patient Specific Implant
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bone Defects, Decompressive Craniectomy and Cranioplasty
Cranioplasty Using Titanium Mesh vs Bone Cement
The aim of this study is: To compare the surgical outcomes between titanium mesh and bone cement in cranioplasty. To assess the complication rates associated with each material.
- Conditions
- Bone Defects, Decompressive Craniectomy and Cranioplasty, Cranioplasty
- Trial name
- NCT06662903
- Testing
- Cranioplasty with Titanium mesh, Cranioplasty with bone cement
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Osman Hassan Osman Zafraan
Craniocerebral Trauma, Stroke
Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes
This prospective, randomized study aims to comprehensively evaluate the impact of cranioplasty timing on postoperative complications and long-term functional outcomes following decompressive hemicraniectomy (DHC).
- Conditions
- Craniocerebral Trauma, Stroke, Intracranial Hemorrhages
- Trial name
- TIMELY (NCT06632587)
- Testing
- Early cranioplasty, Standard-of-care cranioplasty
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Stroke
A Space-expanding Shield in Decompressive Hemicraniectomy for Stroke
Instead of the standard decompressive hemicraniectomy with subsequent cranioplasty a single surgery with the implantation of an individually molded space-expanding shield is investigated in for patients with increased…
- Trial name
- SPACE SHIELD (NCT06638385)
- Testing
- DCE + SPACE SHIELD, DCE + CP
- Where
- 6 sites in Switzerland
- Volunteers
- 110 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cranial Defect, TCD
A Prospective Observational Study of Transcranial Doppler Ultrasound in the Assessment of Cerebral Blood Flow After Polyetheretherketone Cranioplasty
Polyetheretherketone has become one of the most important material choices for cranioplasty surgery. It has been shown that conventional ultrasound can be performed through the polyetheretherketone material for the examination of…
- Trial name
- NCT06642532
- Testing
- TCD group
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Cerebral Decompression Injury
Cranioplasty: Autogenous Bone Graft Versus Artificial Substitutes
Prospective, comparative, observational study. The project's aim is long term follow up of patient's having skull bone defects due to traumatic or lesion resection causes, treated , in standard clinical practice, with autologous…
- Trial name
- NCT03218150
- Testing
- cranioplasty
- Volunteers
- 1 people
- Sponsor
- Assiut University
Cranial Defect
Study on the Effect of Ultra-early Autologous Cranioplasty on Neurological Function Recovery
To compare the neurological recovery and complication rate of autogenous cranioplasty(CP) within 6 weeks after decompressive craniectomy (DC) with that of autogenous cranioplasty within 3~6 months after DC.
- Trial name
- FAST-ECP (NCT07183540)
- Testing
- operation opportunity-within 6 weeks after the DC operation., operation opportunity-within 90 to 180 days after the DC operation.
- Where
- 7 sites in China
- Volunteers
- 582 people
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Ventriculoperitoneal Shunt (VPS), Cranioplasty
Simultaneous Vs Staged VPS and CP :A Multi-cnter RCT.
The purpose of this prospective, multi-center randomized controlled trail is to compare the safety and efficacy of sequential surgery or staged surgery in patients with skull defect and hydrocephalus.
- Trial name
- NCT07462676
- Testing
- Time of choosing VPS and VP
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Anhui Provincial Hospital