Clinical trials: Craniotomy
Inferior Vena Cava, Collapsibility Index
Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesia
This study aims to assess the accuracy, repeatability, and reproducibility of preoperative evaluation of Inferior Vena Cava (IVC) collapsibility index and caval aorta index for prediction of hypotension after induction of general…
- Conditions
- Inferior Vena Cava, Collapsibility Index, Caval Aorta Index, Induction
- Trial name
- NCT07399093
- Testing
- Inferior vena cava collapsibility index, Caval Aorta Index
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Brain Tumor, Primary
Intra-operative Variation in Size of Brain Tumors After Craniotomy
We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain.
- Trial name
- NCT04365647
- Where
- India
- Volunteers
- 51 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Patients Undergoing Elective Craniotomy
Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia
Efficacy of adding low dose ketamine or fentanyl to propofol-dexmedetomidine as total intravenous anesthesia for patients undergoing craniotomy in supra tentorial brain tumor
- Trial name
- TIVA (NCT06031883)
- Testing
- Ketamine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Cerebral Aneurysm, Aneurysm, Middle Cerebral Artery
Safety Study of Minimally Invasive Approaches to Unruptured Anterior Circulation Aneurysms
The study is designed to evaluate the efficacy and safety of minimally invasive neurosurgical techniques for patients with incidental cerebral aneurysms of the anterior circulation in the Hospital das Clínicas of the University…
- Conditions
- Cerebral Aneurysm, Aneurysm, Middle Cerebral Artery, Aneurysm, Anterior Communicating Artery, Aneurysm, Posterior Communicating Artery
- Trial name
- MININCRUSP (NCT02345395)
- Testing
- Aneurysm Clipping
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Pain, Postoperative, Post-Craniotomy Headache
Scalp Infiltration With Diprospan Plus Ropivacaine for Postoperative Pain After Craniotomy in Adults
Pain is common for the first 2 days after major craniotomy. A majority of patients would suffer from moderate-to-severe postoperative pain after undergoing craniotomy.
- Trial name
- NCT04073069
- Testing
- The DR group, The R group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Beijing Tiantan Hospital
Acute Pain, Analgesia
The Relationship Of The Surgical Pleth Index Values With Postoperative Pain Score And Analgesia Consumption
Postoperative pain management has an important role in anesthesia practice. In order to ensure postoperative patient comfort, postoperative rehabilitation should start early and be managed effectively1.
- Trial name
- NCT05147714
- Testing
- Surgical Pleth Index (SPI)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Brain Tumor
Influences of Propofol and Sevoflurane Anesthesia in Brain Tumor
In the preoperative waiting area, the patients are randomly assigned and divided into two groups according to the allocation sequence table (corresponding to 1:1 randomization) generated by the computer.
- Trial name
- anesthetics (NCT05141877)
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 706 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Postoperative Pain, Analgesia
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy
Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure…
- Conditions
- Postoperative Pain, Analgesia, Supratentorial Brain Tumor
- Trial name
- NCT06406829
- Testing
- Dexmedetomidine, Normal saline, Local analgesic techniques
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
ERAS, Craniotomy
A Greek-designed ERAS Protocol in Elective Craniotomy
The implementation of ERAS protocol in elective cranial neurosurgical cases in a tertiary hospital.
- Trial name
- ERAS (NCT05962684)
- Testing
- ERAS
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Awareness, Anesthesia, Arteriovenous Malformations
Awake Craniotomy for Arteriovenous Malformation
The study aimed to retrospectively review cases of brain arteriovenous malformation that were surgical resected with the patient awake during the procedure.
- Trial name
- NCT04949815
- Where
- Pakistan
- Volunteers
- 4 people
- Sponsor
- Aga Khan University
Adult Brain Tumor, Headache
Prevalence of Post-craniotomy Headache in Siriraj Hospital
Headache after major craniotomy may be a problem in taking care of the patients. The investigators want to identify the incidence of headache after major craniotomy and also the risk factors.
- Trial name
- NCT01806155
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Endotracheal Intubation
Dexmedetomidine Versus Lidocaine for Optic Nerve Sheath Diameter During Craniotomy Intubation
Endotracheal intubation during general anesthesia can cause temporary increases in heart rate, blood pressure, and intracranial pressure. These changes may be particularly important in patients undergoing craniotomy.
- Trial name
- NCT07820540
- Testing
- Dexmedetomidine, Lidocaine, Normal Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Benha University
Analgesia Post Craniotomy
Opioid-Sparing Multimodal Analgesia Versus Opioid Analgesia for Postoperative Pain After Elective Craniotomy
Several neurosurgical procedures can cause postoperative pain including craniotomies for tumor resections, epilepsy surgery and craniotomies for aneurysm clipping, penetrating traumatic brain injury, and neuroradiological…
- Trial name
- NCT05474040
- Testing
- Morphine versus multimodal analgesia for post elective craniotomy pain
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Pain, Postoperative, Neurosurgery
Parecoxib as an Adjuvant to Scalp Nerve Blocks for Relief of Post-craniotomy Pain
Pain is common for the first 2 days after major craniotomy. Inadequate analgesia induced sympathetically mediated hypertension may lead to an increased risk for post-operative complications, such as arterial hypertension…
- Trial name
- NCT04034836
- Testing
- Scalp blocks with ropivacaine plus parecoxib, Scalp blocks with ropivacaine and intravenous parecoxib, Scalp blocks with ropivacaine and intravenous saline
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Beijing Tiantan Hospital
Brain Metastases, Adult
A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases
The purpose of this study is to determine if the study drug, patritumab deruxtecan (HER3-DXd), can be measured in brain tumor tissue after recieving one dose of patritumab deruxtecan before surgery.
- Trial name
- PARAMETer (NCT05620914)
- Testing
- Patritumab deruxtecan
- Where
- United States
- Sponsor
- Mustafa Khasraw, MBChB, MD, FRCP, FRACP
Anesthesia
Total Intravenous Anesthesia in Patients Undergoing Craniotomy
Craniotomy presents true anesthetic challenges, mainly due to the need to optimize cerebral perfusion, facilitate brain relaxation, achieve rapid emergence for neurologic assessment, and minimize perioperative complications.
- Trial name
- NCT07105618
- Testing
- Dexmedetomidine, Fentanyl, Magnesium
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Pain, Postoperative, Children
Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-Craniotomy Pain in Children
At present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. On the one hand, professional evaluation of postoperative pain for young children is difficult; on the…
- Trial name
- NCT04051723
- Testing
- The dexamethasone plus ropivacaine, The ropivacaine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Hemodynamic Instability
Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy
The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under…
- Trial name
- NCT06268275
- Testing
- Scalp block, Esmolol
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Brain Neoplasms, Intracranial Aneurysm
Efficiency of Two Glucose Sampling Protocols for Maintenance of Euglycemia
What is the efficacy and safety of q 30 minutes vs. q 1hour glucose sampling and intervention for an intensive insulin protocol to achieve and maintain euglycemia in non-diabetic patients undergoing craniotomy? The investigators…
- Trial name
- NCT00993057
- Testing
- Insulin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Children With Craniosynostoses
Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results
Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to…
- Trial name
- Nautilus (NCT01672619)
- Testing
- dynamic craniotomy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Nucleo de Plastica Avancada