Clinical trials: Craniotomy Surgery
Brain Neoplasms, Surgery
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy…
- Conditions
- Brain Neoplasms, Surgery, Hyperemia
- Trial name
- NCT01642147
- Testing
- Transcranial Doppler (TCD), jugular venous bulb catheterization, Tumor removal surgery under general anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Pain
Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring
This research is being done to compare two methods of giving fentanyl, a narcotic often given to patients following brain surgery and determine if one method has more side effects than the other.
- Trial name
- NCT01327677
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Johns Hopkins University
Infection, Surgery
Topical Vancomycin for Neurosurgery Wound Prophylaxis
This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures.
- Conditions
- Infection, Surgery, Nervous System Diseases
- Trial name
- Vanguard (NCT02284126)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Columbia University
Brain Neoplasm
Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery
Several modalities have been studied to prevent coughing during emergence, including extubation in a deep plane of anesthesia but have proved to be unreliable. So far, no reliable method is recommended as standard of care.
- Trial name
- NCT02964416
- Testing
- Injection Tramadol
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Aga Khan University
Intracranial Surgery
IVPCA in the Management of Pain Following Major Intracranial Surgery
This is a prospective, randomized controlled clinical trial to evaluate the efficacy and safety of intravenous patient controlled analgesia (IVPCA) in patients following major intracranial surgery (e.g.
- Trial name
- NCT00286221
- Testing
- PCA fentanyl, PRN fentanyl
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins University
Surgery
Effect of Remifentanil on Hemodynamic Stability During Placement of a Mayfield Head Fixation Device for Craniotomy
To identify a better method using a combination of routine anesthetic drugs to improve hemodynamic stability during Mayfield head pinning for craniotomy surgery.
- Trial name
- NCT02430389
- Testing
- Remifentanil, Normal Saline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Pneumocephalus
Ventilation With High Oxygen Content and Postoperative Pneumocephalus
The aim of this study is to compare the incidence and volume of postoperative pneumocephalus in patients receiving ventilation with 100% oxygen during the last stage of surgery versus a conventional 1:1 oxygen/air gas mixture.
- Trial name
- NCT02722928
- Testing
- Controlled Ventilation with 100% oxygen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Craniotomy Surgery
Cranial Blocks for Postoperative Anesthesia
This study compares the standard of care to the standard of care plus the administration of bupivacaine or liposomal bupivacaine in patients receiving craniotomies.
- Trial name
- NCT04749797
- Testing
- Liposomal bupivacaine, Bupivacaine Injection, Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pennsylvania
Meningioma
Magnesium and Intraoperative Blood Loss in Meningioma Surgery
Meningioma is the most common central nervous system tumor and craniotomy with tumor removal was associated with moderate blood loss and blood transfusion.
- Trial name
- NCT03558516
- Testing
- Magnesium group, Normal saline group
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Epilepsy
Conscious Sedation for Epilepsy Surgery
Sixty patients were randomly allocated into two groups, group PD and group PR, thirty patients in each group. Patients in PD group received propofol and dexmedetomidine intravenous infusion and patients in PR group received…
- Trial name
- NCT02988050
- Testing
- Remifentanil, Dexmedetomidine, Propofol
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Craniotomy, Brain Surgery
The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period
This is a prospective randomized double blinded trial study involving 128 patients undergoing any craniotomy procedure at Evanston Hospital. The patients will be randomized by the sealed envelope technique.
- Trial name
- NCT01739699
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Endeavor Health
Postoperative Nausea and Vomiting
Effectiveness of Triple Therapy With Palonosetron for PON Prophylaxis
Postoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical patients during the first 24 hours after a surgical procedure.
- Trial name
- NCT02635828
- Testing
- Palonosetron 0.075 mg IV, Dexamethasone 10 mg IV, Promethazine 25 mg IV
- Volunteers
- 40 people
- Sponsor
- Ohio State University