Clinical trials: Creatine Supplementation
Heart Failure
MOre REsponse on Cardiac Resynchronization Therapy With MultiPoint Pacing
The purpose of this Clinical investigation is to assess the impact of the Multi Point Pacing (MPP) feature at 12 months in the treatment of patients not responding to standard Cardiac Resynchronization Therapy (CRT) after 6…
- Trial name
- MORE CRT MPP (NCT02006069)
- Testing
- MPP
- Where
- 206 sites in United States, Australia and 28 more
- Volunteers
- 5,850 people
- Sponsor
- Abbott Medical Devices
Myocardial Lipid
Myocardial Lipid and Creatine of Heart Failure on MRS
The objective of this 3-year project is to develop myocardial MRS, in particular lipid (triglyceride) and creatine resonances, as imaging biomarkers for patients with heart failure (HF).
- Trial name
- NCT02378402
- Testing
- Proton (1H-) magnetic resonance (MR) spectroscopy
- Where
- Taiwan
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy
Creatine Timing and Resistance Training Adaptations.
Emerging evidence suggests that the timing of creatine supplementation may be an important regulator of muscle growth and strength. It is unclear whether creatine ingested before or after resistance training is more beneficial.
- Trial name
- NCT03678857
- Testing
- Creatine
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brandon University
Delayed-Onset Muscle Soreness (DOMS), Exercise-induced Muscle Damage
TENS Versus Foam Rolling for Muscle Recovery After Eccentric Exercise in Elite Female Volleyball Players
Purpose: This study compared two recovery methods-transcutaneous electrical nerve stimulation (TENS) and foam rolling (FR)-for muscle recovery after intense exercise in elite female volleyball players.
- Conditions
- Delayed-Onset Muscle Soreness (DOMS), Exercise-induced Muscle Damage, Muscle Recovery, Athletic Injuries
- Trial name
- TENS-FR-VB (NCT07438197)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Foam Rolling (FR)
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sistan and Baluchestan
Resistance Training, Sports Nutrition
Effects of Three Carbohydrate Beverages on Resistance Training Performance
This randomized, triple-blinded, counterbalanced crossover trial compared three carbohydrate beverages that provided the same amount of carbohydrate (30 g) but differed in carbohydrate source: dextrose, maltodextrin, and highly…
- Conditions
- Resistance Training, Sports Nutrition, Dietary Carbohydrates
- Trial name
- NCT07874776
- Testing
- Dextrose, Maltodextrin, Highly Branched Cyclic Dextrin
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Healthy
Interval Training Plus Creatine Effects on Performance and Glucose Tolerance
Recent evidence suggests that high -intensity interval training (HIIT) may be an effective strategy to improve cardiorespiratory fitness, exercise performance, and insulin sensitivity.
- Trial name
- Cr + HIIT (NCT02370212)
- Testing
- Creatine, High intensity interval training
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Major Depressive Disorder
5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females
The investigators hypothesize that the administration of two widely available, naturally occurring dietary supplements, 5 hydroxytryptophan and creatine monohydrate, will reduce the severity of depression in individuals exposed…
- Trial name
- NCT02356107
- Testing
- 5-hydroxytryptophan and Creatine monohydrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Muscle Weakness
Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training
To determine, in a double blind trial, the effects of creatine supplementation during 12 weeks on muscle mass and function of community living older women subjected to resistance training.
- Trial name
- NCT02188849
- Testing
- Resistance exercise training, Creatine
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chile
Major Depressive Disorder
5-HTP and Creatine for Depression R33 Phase
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression.
- Trial name
- NCT05895747
- Testing
- Low Dose 5-hydroxytryptophan, High Dose 5-hydroxytryptophan, Low Dose Creatine Monohydrate
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Utah
Frailty
Relationship Between Albumin/Creatine Ratio, B12, Folate, and Frailty Index
In the literature, the relationship between frailty and various blood tests such as beta-2 microglobulin, CRP, procalcitonin, vitamin D, IL-1, and IL-6 has been investigated (2).
- Trial name
- NCT06393647
- Testing
- Frailty scale forms (Frailty Scale Version 9)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Bipolar I Disorder, Psychosis
Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder
This is a randomized, controlled clinical trial to assess the effects of the ketogenic diet in combination with treatment as usual on brain energy metabolism and psychiatric symptoms in individuals with first episode bipolar…
- Conditions
- Bipolar I Disorder, Psychosis, Schizoaffective Disorder
- Trial name
- NCT06221852
- Testing
- Ketogenic diet, Dietary Guidelines for Americans
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Copd, Athletes
Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients
Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body.
- Trial name
- NCT06991426
- Testing
- CreaSafe® creatine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Major Depressive Disorder
Creatine as a New Therapeutic Strategy in Depression
Creatine as a new therapeutic strategy in depression: A double-blind, parallel, randomized, add-on clinical trial of creatine versus placebo added to antidepressant treatment of patients with major depressive episode.
- Trial name
- NCT00313417
- Testing
- Creatine monohydrate
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Herzog Hospital
Hematologic Test
Effects of HIIT on Plasma Volume and Aerobic Capacity in Obese Adolescent Girls
The goal of this clinical trial is to investigate the impact of high-intensity interval training (HIIT) program on body composition, hematological parameters, plasma volume variations (PVV), muscle damage markers, and aerobic…
- Trial name
- NCT07046520
- Testing
- High intensity interval training
- Where
- Tunisia
- Volunteers
- 28 people
- Sponsor
- High Institute of Sports and Physical Education of Kef
HIV Infections
Effects of Creatine and Resistance Exercise Training in People With HIV Infection
This study was designed determine whether use of creatine monohydrate, a dietary supplement, can increase skeletal muscle mass and strength and improve the response to progressive resistance exercise training in people with HIV…
- Trial name
- NCT00484627
- Testing
- Use of creatine monohydrate (a dietary supplement), Progressive resistance exercise training
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Depression, Dual Diagnosis
Open-Label Creatine Study for Female Meth Users
Study Purposes and Objectives: The objectives should be stated in such a way that the reader can determine the appropriateness of the study design. If appropriate, state the specific hypotheses being tested and/or study aims.
- Conditions
- Depression, Dual Diagnosis, Substance Use
- Trial name
- NCT02189915
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Seizure, Syncope
Lactate Compared to Creatine Kinase as Diagnostic Marker in Generalized Epileptic Seizure
The investigators compared the feasibility of serum creatine kinase and serum lactate concentration as diagnostic markers to distinguish between generalized tonic-clonic seizures (GTCS) and syncopes in clinical settings that…
- Trial name
- NCT02926703
- Testing
- Serum lactate and CK concentrations in blood samples
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- RWTH Aachen University
Muscle Weakness
Delivra Topical Creatine Combined With Oral Creatine for Improving Muscular Power
Creatine is a nutritional supplement that is often ingested to improve exercise performance. The advent of a new product that is applied to the skin overlying muscle offers potential benefit, if the creatine can be targeted to…
- Trial name
- NCT03006861
- Testing
- 3.5 mL/d topical creatine, 21 g/d Oral creatine
- Where
- 3 sites in Canada
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Dietary Supplementation
Physiological Effects of Creatine Supplementation in Active Males
This study was designed to examine how different forms of creatine impact active males.
- Trial name
- NB4 (NCT03003988)
- Testing
- Creatine monohydrate, Creatine nitrate
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Physical Inactivity
Blood Flow Restriction and Creatine Supplementation in Women
This research is examining the changes in muscle size, muscle function, body composition, strength, and blood vessel health. Specifically, the changes in these variables over the course of 8 weeks of training with or without…
- Trial name
- NCT05877417
- Testing
- Creatine Monohydrate, Blood Flow Restriction, Exercise
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Central Florida