Clinical trials: Critical Care
Critical Illness, Intensive Care
Early Exercise Training in Critically Ill Patients
This randomized controlled trial was designed to investigate whether a daily training session using a bedside cycle ergometer, started early in stable critically ill patients with an expected prolonged ICU stay, could induce a…
- Conditions
- Critical Illness, Intensive Care, Muscle Weakness, Deconditioning
- Trial name
- NCT00695383
- Testing
- Bedside cycle exercise therapy, Standard physiotherapy program
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
Critical Illness, Mechanical Ventilation
Proof of Concept Trial to Confirm That the Recovery of Patients Treated in the Intensive Care Unit Requiring Mechanical Ventilation is Beneficially Affected by the Environmental Simulation of Daytime and Night Time Alternation as Well as by the Nutrition Protocol Corresponding to the Daily Rhythm
The purpose of this study is to determine whether the environmental simulation of daytime and night time alternation as well as by the nutrition protocol corresponding to the daily rhythm are beneficially affect the recovery of…
- Trial name
- NCT02828722
- Testing
- Controlled light and noise, Controlled nutrition
- Where
- Hungary
- Volunteers
- 45 people
- Sponsor
- Achros Health Technologies Corporation
Upper Abdominal Surgery, Critical Ill Patients in SICU
Non-Invasive Respiratory Monitoring to Predict Successful Separation From Mechanical Ventilation Following Upper Abdominal Surgery
The VALUE Study is a two-phase, prospective clinical trial conducted at King Chulalongkorn Memorial Hospital (KCMH). The study evaluates the prevalence of mechanical ventilation (MV) separation failure in post-open upper…
- Trial name
- VALUE (NCT07678502)
- Testing
- High Flow Oxygen, Nasal canula oxygen
- Volunteers
- 40 people
- Sponsor
- Papawee Chennavasin
Pain, Acute, Nociceptive Pain
The Nociception Level (NOL) Index for Pain Assessment in the Adult Intensive Care Unit
Assessing pain in the adult intensive care unit (ICU) is challenging because many patients are unable to communicate due to mechanical ventilation and sedation.
- Conditions
- Pain, Acute, Nociceptive Pain, Behavior, Critical Illness
- Trial name
- NOL-ICU (NCT05339737)
- Testing
- Nociception Level (NOL) Index
- Volunteers
- 411 people
- Sponsor
- McGill University
Critical Care Medicine, Mechanical Ventilation
Evaluating the Clinical Effectiveness of "Endotracheal Tube Position Anomaly Alerting System"
The goal of this clinical trial is to determine whether the Endotracheal Tube Position Anomaly Alerting System (ETPAAS) effectively reduces the duration of endotracheal tube malposition in patients admitted to the intensive care…
- Conditions
- Critical Care Medicine, Mechanical Ventilation, Radiographic Image Interpretation, Computer-Assisted, Alarms
- Trial name
- ETPAAS-1 (NCT06857019)
- Testing
- "Endotracheal Tube Position Anomaly Alerting System"
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Pain, ICU Delirium
Validation of the Polish Version of CPOT
Pain experienced by critically ill patients is a major problem affecting nearly 50% of the patients. Assessing pain in critically ill patients is a challenge even in an intensive care unit (ICU) with a minimal opioid-based…
- Trial name
- POL-CPOT (NCT03024528)
- Testing
- CPOT assessment
- Where
- Poland
- Volunteers
- 71 people
- Sponsor
- Pomeranian Medical University Szczecin
Bacteremia, Intensive Care
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness
The World Health Organization, U.S. Centers for Disease Control and Prevention, Association of Medical Microbiology and Infectious Diseases (AMMI) Canada, and Health Canada have all declared antimicrobial resistance a global…
- Conditions
- Bacteremia, Intensive Care, Critically Ill, Sepsis
- Trial name
- BALANCE (NCT03005145)
- Testing
- 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.
- Where
- 68 sites in United States, Australia and 5 more
- Volunteers
- 3,622 people
- Sponsor
- Sunnybrook Health Sciences Centre
Intensive Care Unit Syndrome, Disabilities Multiple
Post-Intensive Care Transitional Care, Rehabilitation, and Family-Support
The goal of this randomized control trial is to test an intervention designed to improve patient and family outcomes after critical illness compared to usual care.
- Conditions
- Intensive Care Unit Syndrome, Disabilities Multiple, Critical Illness, Caregiver Burden
- Trial name
- PIC-TRFS (NCT06501365)
- Testing
- Post Intensive Care Transitions Rehabilitation and Family Support (PIC-TRFS), Enhanced Usual Care Control
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pittsburgh
Epilepsy
Assessment of Remote EEG Monitoring (REMI-EEG) in Pediatric Emergency and Adult Critical Care Units
The goal of this observational study is to compare clinical utility between Remote EEG Monitoring (REMI) and conventional EEG in patients (6 and older) that are undergoing EEG recording in a hospital as part of their routine…
- Trial name
- NCT05818930
- Testing
- REMI
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Epitel, Inc.
ICU Acquired Weakness, Weaning Failure
Predictors of Prognosis in Patients With Critical Illness.
Recently, intensive care unit acquired weakness (ICUAW) has become a hotspot issue in the patients with critical illness. The symptoms of ICUAW, including sensory impairment and muscle atrophy, may lead to poor quality of life…
- Conditions
- ICU Acquired Weakness, Weaning Failure, Quality of Life
- Trial name
- NCT04914065
- Testing
- Regular care in the surgery intensive care unit
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taoyuan General Hospital
Respiratory Distress Syndrome, Adult, Critical Illness
Measuring Heart and Lung Function in Critical Care
This is a feasibility study of the use of a novel technique called 'Inspiwave' to measure heart and lung function in adult patients in critical care.
- Conditions
- Respiratory Distress Syndrome, Adult, Critical Illness, Mechanical Ventilation Complication, Haemodynamic Instability
- Trial name
- NCT03424798
- Testing
- Inspiwave
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Psychosocial Intervention, Intensive Care Units (ICUs)
Study Protocol for a Pilot Randomized Controlled Trial of a Psychosocial Care Intervention in Intensive Care
This Pilot-RCT is part of a feasibility study that aims to learn if the IPS-psychosocial care intervention and an RCT on its efficacy are feasible in patients, relatives and staff on icu wards.
- Conditions
- Psychosocial Intervention, Intensive Care Units (ICUs), Psychosocial Health
- Trial name
- IPS-Pilot (NCT06733493)
- Testing
- integrated psychosocial care
- Where
- 4 sites in Germany
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Harald Gündel
Critical Illness
Dose of Early Therapeutic Mobility: Does Type or Frequency Matter?
This study will examine the effects of once and twice daily activity performed with patients who are breathing with the aid of a machine in an intensive care unit. Activity can occur in bed.
- Trial name
- ETM (NCT00999011)
- Testing
- once daily mobility activity, twice daily mobility activity
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Case Western Reserve University
Acute Respiratory Failure Requiring Intubation
Bougie Versus Endotracheal Tube Alone on First-attempt Intubation Success in Prehospital Emergency Intubation (BETA Trial)
Emergency intubation is routinely performed in the prehospital setting. Airway management in the prehospital setting has substantial challenges, such as hostile environment or lack of technical support in case of first attempt…
- Trial name
- BETA (NCT06307392)
- Testing
- First intubation attempt with endotracheal tube plus bougie, First intubation attempt with endotracheal tube alone
- Where
- 10 sites in France
- Volunteers
- 710 people
- Sponsor
- Nantes University Hospital
Sepsis
Procalcitonin-Guided Antimicrobial Discontinuation
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confirmed sepsis.
- Trial name
- NCT00250666
- Testing
- PCT measurement
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Critical Illness, Sedation
Sedation Practices and Preferences of Turkish Intensive Care Physicians: National Survey
Sedation is one of the most common practices applied in intensive care units (ICU) and the management of sedation, analgesia and delirium is a quality measure in ICUs.
- Trial name
- NCT03488069
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Infectious Diseases
Safety and Efficacy Study of High Dose Colistin
Colistin is a rapidly acting bactericidal antimicrobial agent that possesses a post antibiotic effect against MDRO Gram-negative bacteria, such as as Pseudomonas aeruginosa, Acinetobacterbaumannii, and Klebsiella pneumonia.
- Trial name
- NCT02162966
- Testing
- High Dose Colistin, Standard Dose Colistin
- Where
- Saudi Arabia
- Volunteers
- 330 people
- Sponsor
- King Saud Medical City
Cardiogenic Shock
The Clinical and Hemodynamic Course of Cardiogenic Shocks Hospitalized in Critical Care
Cardiogenic shock is a frequent reason for hospitalization in critical care units, with high mortality (50%). Several French registries have been created to improve knowledge of the prognostic factors of cardiogenic shock.
- Trial name
- HEMOCARD (NCT05752383)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Dysphagia, Critical Illness
Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial
This research study is investigating the efficacy and implementation of expiratory muscle strength training (EMST), standard of care dysphagia treatment, and intensive dysphagia treatment in critically ill adults in the acute…
- Trial name
- NCT07736105
- Testing
- Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis
Clinical Protocol Validation to Identify Prognostic Markers for Critical Care Pediatric Patients
The purpose of this study is to monitor the respiratory, metabolic and nutritional status of critically ill pediatric patients undergoing mechanical ventilation and to correlate the clinical and physiopathological findings with…
- Trial name
- PCL07 (NCT00792883)
- Where
- Brazil
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation