Clinical trials: Critical Care Medicine
Death
Advance Directives and End-of-life Decision Making in Intensive Care Medicine in Germany
Description of the decision making process as well as the practices of end of life care in an ICU of a German university hospital during the period when changes of German legislation occurred.
- Trial name
- NCT01294189
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Charite University, Berlin, Germany
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
Sepsis
Early Vasopressors in Sepsis
Sepsis is a life-threatening reaction to an infection. It happens when the immune system overreacts to an infection and starts to damage the body's tissues and organs.
- Trial name
- EVIS (NCT05179499)
- Testing
- Norepinephrine, Balanced Crystalloid
- Where
- 25 sites in United Kingdom
- Volunteers
- 1,006 people
- Sponsor
- NHS Greater Glasgow and Clyde
ARDS, Sepsis
Drug Monitoring of Antibiotics in Critical Care Patients
Infections are critical factors for the survival of critically ill patients. A broad, high-dose and early initial therapy of antibiotics is of particular relevance.
- Trial name
- DRAK (NCT01793012)
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Injury
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management.
- Trial name
- PRiMe (NCT03470844)
- Testing
- Face-to-face neurocognitive tests, Psychological screening, fMRI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Long-term Outcome, Extracorporeal Membrane Oxygenation
Long Term Outcome of Extracorporeal Membrane Oxygenation Patients in China
Outcomes and Long-term Quality-of-life of Patients requiring Extracorporeal Membrane Oxygenation are not known in china. A prospective study survey will be performed to assess the long-term outcome of these patients.
- Trial name
- ECMO (NCT03345758)
- Testing
- outcome
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Southeast University, China
Critical Illness
Enhanced Recovery After Intensive Care (ERIC)
The primary objective of the multi-center stepped-wedge cluster-randomized controlled trial ERIC is to evaluate the effects of a multi-component telemedicine-based intervention delivered by the ICU on the adherence to quality…
- Trial name
- NCT03671447
- Testing
- ICU Usual Care, Tele-ICU
- Where
- 13 sites in Germany
- Volunteers
- 1,463 people
- Sponsor
- Charite University, Berlin, Germany
Aged, Critical Care
Impact of the Intervention of Pharmacists and Geriatrician on Drug Prescription in Elderly Patients in a Surgical ICU
In order to optimize drug prescription and to reduce potentially inappropriate medications, a pharmaceutical analysis activity is conducted in our establishment for several years.
- Trial name
- IATROAGE (NCT03706092)
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Critical Care Medicine, Mortality Prediction
Clinical Validation of a Pre-trained and Fine-tuned Model for Analyzing Time-Series Electronic Health Records in Critical Care
The goal of this observational study is to validate the generalization capability and predictive performance of the "Time-Series Electronic Health Record Foundation Model (EHR Foundation Model)", which was pre-trained on a…
- Trial name
- NCT07795450
- Where
- China
- Volunteers
- 4,800 people
- Sponsor
- Peking University People's Hospital
Communication
Communication Skills Training and Competency Assessment for Pulmonary and Critical Care Medicine Fellows
Study to determine if pulmonary/critical care fellows will demonstrate increased competency in the behavioral skills necessary to facilitate family meetings focused on discussions of goals of care in the ICU from pre- to…
- Trial name
- NCT01249170
- Testing
- First year program, Control comparison
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jennifer McCallister MD
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Weaning
Effect of NAVA on Weaning Duration in Difficult to Wean Patients
It has been showed that over assist and patient ventilator asynchrony often occur in mechanical ventilated patients, especially in patients who failed weaning, which are associated with a prolonged duration of mechanical…
- Trial name
- NCT01280773
- Testing
- NAVA
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Ling Liu
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)
Retrospective observational cohort study including all patients admitted for toxidermia (Lyell syndrome, Stevens-Johnson Syndrome (SJS), or other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn…
- Trial name
- TEN metabolism (NCT05320653)
- Testing
- Medical nutrition
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Critically Ill, Intensive Care (ICU)
Factor Associated With Mortality in the ICU
ICU mortality indicates the severity of disease, healthcare quality, and the efficacy of interventions. The severity scores are tools to predict the risk of mortality in the ICU, and the APACHE II score is frequently used for…
- Conditions
- Critically Ill, Intensive Care (ICU), Intensive Care Medicine, Mortality
- Trial name
- ICUMortal (NCT07249749)
- Testing
- Exposure factors
- Where
- Colombia
- Volunteers
- 1,000 people
- Sponsor
- Hospital Departamental de Villavicencio
Cardiac Arrest
Cardiopulmonary Resuscitation in Cases of Sudden Cardiac Arrest
Determination the success rate of CPR on adults in Emergency room and predicting the factors that makes CPR is successful.
- Trial name
- NCT05716789
- Testing
- CPR
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Egymedicalpedia
Critical Care, Rehabilitation
Differences in Frail and Non-frail Critically-ill Patients in Functional Outcomes
This is a prospective analysis of patient registry data of intensive care patients. The aim is to investigate if frailty is a predictor of decline of functional status of critically ill patients during their hospital stay.
- Conditions
- Critical Care, Rehabilitation, Outcome Assessment, Critical Illness
- Trial name
- DEFAULT (NCT03789305)
- Where
- Germany
- Volunteers
- 731 people
- Sponsor
- Technical University of Munich
PTSD, Post ICU Syndrome
Intensive Care Unit (ICU) Diary Project
Psychological morbidity in both patients and family members related to the intensive care unit (ICU) experience is an often overlooked, and potentially persistent, healthcare problem recognized by the Society of Critical Care…
- Trial name
- NCT04305353
- Testing
- Diary (blank journal) plus PTSD psycho-education, PTSD psycho-education alone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tulane University School of Medicine
Neurotoxicity, Sepsis
Neurotoxicity Evaluation of Beta-lactams in Intensive Care Unit and Identification of the Risk Factors
Beta-lactams are the most prescribed antibiotics in intensive care units. The lack of linearity between the dose administered and the exposition due to the very high variability of the pharmacokinetics in critically ill patients…
- Conditions
- Neurotoxicity, Sepsis, Beta Lactams, Therapeutic Drug Monitoring
- Trial name
- NebuLar (NCT03628300)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Anesthesia
Survey of Anesthesiology Residents' Perceptions of Critical Care Medicine as a Career
This study's goal is to investigate the reasons behind the decline in interest in critical care fellowships among anesthesia residents.
- Trial name
- NCT05566067
- Testing
- Survey
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University