Clinical trials: Critical Ill Patients
Critical Illness
The Optimization of Procedural Pain Control in Intensive Care Unit (ICU) Patients
The purpose of this study is to determine the influence of morphine 2,5 mg or morphine 7,5 mg iv during a painful and unavoidable intervention in critically ill patients.
- Trial name
- OPCIC (NCT00558090)
- Testing
- morphine
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Critical Illness, Infection Complication
A Trial of Enteral Colostrum on Clinical Outcomes in Critically Ill Patients
Enteral administration of immune-modulating nutrients such as glutamine, omega-3 fatty acids, selenium, and antioxidants has been suggested to reduce infections and improve recovery from critical illness.
- Conditions
- Critical Illness, Infection Complication, Multiple Organ Dysfunction Syndrome
- Trial name
- NCT03019250
- Testing
- Colostrum, Maltodextrin
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- National Nutrition and Food Technology Institute
Physiological Monitoring, Critically Ill
Comparative in Patient, Non-intervention Study of the Remote Physiological Monitoring System (RPM™) vs Standard Physiological Monitoring Devices
The Remote Physiological Monitoring System (RPM™) is a wireless technology for physiological monitoring. The RPM™ is designed to capture, transmit and remotely monitor the vital signs of a patient or group of patients.
- Trial name
- NCT00664924
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Kidney Injury
The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy
This study aims to investigate shorter vs. standard filter lifespans in critically ill patients receiving continuous renal replacement therapy (CRRT) for acute kidney injury (AKI).
- Trial name
- SPECIAL (NCT07630220)
- Testing
- time span of filter change
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universität Münster
Anemia
Transfusion Requirements in Critically Ill Oncologic Patient
Blood transfusion in critical ill patients has been associated to several complications and worse outcome. Particularly in oncologic patients, red blood cell transfusion has been investigated as a factor of worse outcome and…
- Trial name
- TRICCOP (NCT01648946)
- Testing
- Red blood cell transfusion
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Critical Illness, Metabolism and Nutrition Disorder
Endogenous Energy Production in Critically Ill Patients
The aim of this study is to investigate when critically ill patients transition from a non-suppressible catabolism to a normal response to feeding.
- Trial name
- eEPIC (NCT07059988)
- Testing
- Stable isotope tracers, Parenteral nutrition
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Critical Illness, Inflammation
Amino Acid Nutrition in the Critically-ill
Enhancing the anabolic effect of nutrition in critically ill patients by administering exogenous amino acids.
- Conditions
- Critical Illness, Inflammation, Malnutrition
- Trial name
- AA-ICU (NCT02865408)
- Testing
- Peptamen 1.5% via enteral, Prosol 20% IV to 1.75g/kg/day, Prosol 20% IV to 2.5g/kg/day
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Arnold Kristof
Cancer, Critical Care, Cancer Critically Ill
Admission, Triage, and Discharge Criteria for Oncological Patients in the Intensive Care Unit
This study will create one agreed set of rules to help doctors decide which people with cancer should be treated in an intensive care unit (ICU), and when they are well enough to leave it.
- Trial name
- ONCO-TRIAD (NCT07809490)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Onco Critical Care Society
COVID-19, Deep Vein Thrombosis
Evaluating Dose Regimen of Intravenous Unfractionated Heparin and Low Molecular Weight Heparin in Critical Ill Patients Versus Critical Ill COVID-19 Patients Using Anti-Xa Levels.
To see whether our increased dosing regimen of unfractionated heparin (UF) and low molecular weight heparin (LMWH) in COVID-19 patients was effective at preventing thrombo-embolic complications.
- Conditions
- COVID-19, Deep Vein Thrombosis, Anticoagulants and Bleeding Disorders, Critical Illness
- Trial name
- NCT05224388
- Testing
- Enoxaparin, Heparin
- Where
- Belgium
- Volunteers
- 813 people
- Sponsor
- University Hospital, Ghent
Pneumonia
Effect of High Dose Intravenous Vitamin C in Severe Pneumonia
This trial is a multicenter, randomized, double-blind, two-arm, parallel-group, placebo-controlled trial to investigate the effect of high dose intravenous (IV) Vitamin C as an adjunct to the standard of care for patients with…
- Trial name
- VICSEP (NCT05842382)
- Testing
- Active Ingredient
- Where
- 3 sites in Malaysia
- Volunteers
- 484 people
- Sponsor
- Clinical Research Centre, Malaysia
Critical Illness, Therapeutic Drug Monitoring
Anti-Xa Level With Thromboprophylactic Dosage Nadroparin in Critically Ill COVID-19 and Non-COVID-19 Patients
Primary objective The objective of this study is to compare anti-Xa levels obtained with a standard high dose thrombosis prophylaxis in COVID-19 intensive care-patients compared with anti-Xa levels obtained with a normal dose…
- Conditions
- Critical Illness, Therapeutic Drug Monitoring, Venous Thromboembolism
- Trial name
- NADRO (NCT05926518)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Rijnstate Hospital
Mechanical Ventilation Pressure High, Critical Illness
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all.
- Trial name
- NCT06393179
- Testing
- pressure-volume curve with a low-flow insufflation of 5 L/min
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
Septic Shock, Antibiotic Resistant Infection
Pharmacokinetics of High-dose Tigecycline in Critically Ill Patients
The objective of this study is to describe the pharmacokinetics of tigecycline in critically ill patients receiving continuous venovenous haemodialysis (CVVHD) and to evaluate the frequency of pharmacokinetic/pharmacodynamic…
- Conditions
- Septic Shock, Antibiotic Resistant Infection, Critical Illness
- Trial name
- NCT03034174
- Where
- Poland
- Volunteers
- 37 people
- Sponsor
- Medical University of Lublin
Noise; Adverse Effect
Noise in Critical Care Units.Impact on Critically Ill Patients and Healthcare Personnel
Study noise level in the ICU and its effect on both patients and healthcare personnel. Use music and study same effects on same patients and healthcare personnel.
- Trial name
- NCT04164498
- Testing
- music
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Critical Illness, Pharmacokinetics
Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis
WP1.1. PK/PD target attainment: Plasma exposure, Excretion via urine \& ELF exposure; WP1.2. Predictive dosing algorithm; WP1.3. ECMO subset
- Trial name
- NCT03560557
- Volunteers
- 116 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ascites Hepatic, Cirrhosis, Liver
Continuous Passive Paracentesis for Intra-abdominal Hypertension
Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Hypertension, Intraabdominal, Critical Illness
- Trial name
- COPPTRIAHL (NCT04322201)
- Testing
- continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter, Ultrasound-guided intermittent large-volume paracentesis
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Dysphagia, Sarcopenia
Masseter and Rectus Femoris Ultrasound for Dysphagia and Sarcopenia in Critically Ill Patients
Dysphagia and sarcopenia are common complications in critically ill patients and are associated with increased morbidity, prolonged hospitalization, nutritional complications, and poorer clinical outcomes.
- Trial name
- NCT07787312
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Sara Casanova Prieto
Diabetes Mellitus, Critical Illness
Degludec Insulin Use in Critically Ill Patients
Background: Dysglycemia in critically ill patients is common, where 40% to 54% of patients were found to be hyperglycemic on intensive care unit admission.
- Conditions
- Diabetes Mellitus, Critical Illness, Hyperglycemia
- Trial name
- NCT06056167
- Testing
- Degludec insulin
- Where
- Saudi Arabia
- Volunteers
- 155 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Critically Ill, Oral Health Care
Professional Oral Care and Staff Education in Critically Ill Patients
This study evaluated oral health in critically ill patients admitted to two intensive care units in Budapest, Hungary, and examined whether professional oral care and education of intensive care staff could improve oral hygiene.
- Conditions
- Critically Ill, Oral Health Care, Critical Illness, Oral Care Performance
- Trial name
- NCT07831564
- Testing
- Professional Oral Care, Standard Oral Care, ICU Staff Oral Care Education
- Where
- 2 sites in Hungary
- Volunteers
- 161 people
- Sponsor
- Semmelweis University
Critical Illness, Critically Ill Patients
Physiological Changes in Adult Intensive Care Patients Following Contact With Their Primary Caregiver
Patients admitted to intensive care units are exposed to multiple environmental and clinical factors that may affect their physiological responses.
- Trial name
- CARE-ICU (NCT07761364)
- Testing
- Standardized therapeutic physical contact
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Autonoma del Estado de Mexico