Clinical trials: Critical Ill Patients
Critically Ill
ICG- Liver Test Versus New Biomarkers as Prognostic Markers in Critically Ill Patients
Comparison of ICG liver testing with copeptin and SAPS II score as prognostic markers in critically ill patients.
- Trial name
- Greenpep (NCT01126554)
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- University of Zurich
Critical Illness, Dietary Modification
Meeting Protein Targets in Critically Ill Patients
This is a retrospective study of protein and energy intake in enterally fed critically ill adult patients before and after the introduction of a very high protein enteral nutrition formula in a single center medical/surgical ICU.
- Trial name
- PROTARGET (NCT03319836)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Société des Produits Nestlé (SPN)
Critical Illness
Metabolic Determinants Of Resting Energy Expenditure Among Mechanically Ventilated Critically Ill Patients
Currently there are no study related to Indirect Calorimetry (IC) has been done among hospitalised Malaysian ICU adult patients with its racial mix.
- Trial name
- NCT03319329
- Testing
- Indirect Calorimetry
- Where
- Malaysia
- Volunteers
- 314 people
- Sponsor
- University of Malaya
Fluid Balance, Acute Kidney Injury
Fluid Balance in Acute Kidney Injury in Critically Ill Patients
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults.
- Conditions
- Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill
- Trial name
- NCT07338734
- Volunteers
- 120 people
- Sponsor
- Assiut University
Cross Infection (Hospital-Acquired Infections), Critical Illness
Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study
This pilot randomized clinical trial investigated the effect of probiotic supplementation on the incidence of intensive care unit-acquired infections (ICU-AIs) in critically ill patients.
- Conditions
- Cross Infection (Hospital-Acquired Infections), Critical Illness, Probiotic Intervention
- Trial name
- NCT07144124
- Testing
- Biopro-max 8 Billion Probiotics (Bioserv Healthcare)
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Critical Illness
Prospective Clinical Surveillance With Application of Trigger Tools in Critically Ill Patients
This study evaluates the impact of prospective clinical surveillance with the use of triggers to identify risk of adverse events with prompt adoption of interventions on the stabilization time of critically ill patients.
- Trial name
- NCT03781713
- Testing
- KDIGO, Delta SOFA, Hypoglycemia
- Where
- 2 sites in Brazil
- Volunteers
- 1,200 people
- Sponsor
- Hospital Sao Domingos
Multi-resistant Gram-negative Bacteria Cause Infection
GRAM NEGATIVES STUDY
This is a prospective, observational, multicenter study whose main objective is to develop a predictive model of mortality in critically ill patients colonized by multidrug-resistant Gram-negative bacteria (MDR-GNB).
- Trial name
- MR-GEIPC (NCT07749508)
- Testing
- Standard of care therapy
- Where
- Spain
- Volunteers
- 1,500 people
- Sponsor
- Fundacion SEIMC-GESIDA
Critical Illness, Pupillometry
Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study
This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to…
- Conditions
- Critical Illness, Pupillometry, Prognosis
- Trial name
- PUPIL (NCT07616518)
- Volunteers
- 700 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Nutrition, Critical Illness
Micronutrients in Critically Ill Patients
Nutritional support is an important component of modern critical care. The practice of vitamin and micronutrient supplementation is variable and official guidelines are not consistent.
- Conditions
- Nutrition, Critical Illness, Vitamin Supplementation
- Trial name
- MiNuCrit (NCT04136119)
- Testing
- questionnaire
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Frailty Syndrome
Adaptation and Validation of Frailty Scales in Intensive Care Units in Spain
Increased life expectancy leads to population aging, increased morbidities and aging of hospitalized patients. The acquisition of frailty leads to worse outcomes derived from hospitalization, but although frailty has been related…
- Trial name
- NCT04830865
- Where
- Spain
- Volunteers
- 512 people
- Sponsor
- Hospital Universitario Getafe
Critical Illness, Respiratory Failure
International Observational Study on Airway Management in Critically Ill Patients
Endotracheal intubation (ETI) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common.
- Conditions
- Critical Illness, Respiratory Failure, Hemodynamic Instability, Coma
- Trial name
- INTUBE (NCT03616054)
- Where
- Italy
- Volunteers
- 3,600 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Critical Illness, Intensive Care Unit Acquired Weakness
Virtual Reality Rehabilitation on the Intensive Care Unit for Critically Ill Patients
Feasibility study of the use of an interactive Virtual Reality device in rehabilitation of critically ill patients on the Intensive Care Unit.
- Trial name
- VRR-ICU (NCT05591248)
- Testing
- VRR
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Airway Management, Tracheal Intubation
Curriculum for Airway Skills in Critically Ill Adults: a Delphi Evaluation
This study using a Delphi methodology, and involving international experts, will help define a training curriculum for physicians involved with airway management in critically ill patients.
- Conditions
- Airway Management, Tracheal Intubation, Critical Illness, Training
- Trial name
- CASCADE (NCT06689748)
- Testing
- Delphi procedure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Acute Respiratory Distress Syndrome, Cardiac Failure
Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients
Patients in end-stage cardiac failure and/or respiratory failure may be started on a rescue therapy known as Extracorporeal Membrane Oxygenation (ECMO).
- Conditions
- Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure
- Trial name
- IGNITE (NCT04669444)
- Testing
- Ventilator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Hyperglycemia, Cardiac Surgery
Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients
The purpose of this study is to evaluate the safety and efficacy of a system combining continuous glucose measurement with a computer-based algorithm for insulin delivery in patients undergoing elective cardiac surgery.
- Trial name
- NCT00996099
- Testing
- Continuous glucose monitoring system combined with enhanced model predictive control algorithm for intensive insulin treatment, Intensive insulin therapy using standard protocol
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- Charles University, Czech Republic
Critical Illness
Glycemic Index Variation During Low-carbohydrate Enteral Formula With and Without Fructose in Critically Ill Patients
Hyperglycemia is a known risk factor for mortality in critically ill patients. Most of these patients receive enteral feeding. There is controversy about ideal carbohydrate composition of these diets.
- Trial name
- NCT03003507
- Testing
- Enteral Formula With Fructose, Enteral Formula Without Fructose
- Volunteers
- 25 people
- Sponsor
- Hospital Moinhos de Vento
Sedation and Analgesia
Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam
In this parallel, multicenter, single-blind randomized controlled trial, mechanical ventilated patients will be randomly assigned to two groups.
- Trial name
- NCT05160987
- Testing
- Remimazolam, Midazolam
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Zhujiang Hospital
Intensive Care Unit Acquired Weakness
Efficacy and Safety of Administration of High Levels of Protein to Critically Ill Patients.
Critically ill patients are known to develop serious nutritional deterioration during the course of their disease. They develop, from the beginning, a multifactorial protein malnutrition that relates to a poor clinical course and…
- Trial name
- FISIO (NCT05918757)
- Testing
- Protein dose 1.5 g/kg/day, Protein dose 1.0 g/kg/day
- Where
- 18 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Critical Care Medicine and Coronary Units
Critical Illness
Study of Arginine Free IED in Critically Ill Patients.
This study intends to investigate the clinical outcomes of a new immunoenhancing formula which composed arginine free compare to isonitrogenous, isocaloric standard formula in ICU patients.The study design is multicenter…
- Trial name
- ROSIED (NCT01713257)
- Testing
- Immunoenhancing diet, Isocaloric, isonitrogenous diet
- Where
- 3 sites in Thailand
- Volunteers
- 172 people
- Sponsor
- Thai Otsuka Pharmaceutical Co., Ltd.
Critically Ill
Efficacy of Nasojejunal Enteral Feeding in Critically Ill Patients.
The purpose of this study is to determine if naso-jejunal feeding (feeding beyond the stomach) improves the efficacy of enteral feeding (feeding into the gut) in critically ill patients.
- Trial name
- NCT00256048
- Testing
- Nasojejunal feeding
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Melbourne Health