Clinical trials: Critical Ill Patients
Dietary Supplements, Intensive Care Unit
Vitamin D Supplementation in Intensive Care Unit Patients
A randomized controlled trial is designed to investigate the safety and clinical efficacy of a mega dose of VD in patients admitted in intensive care unit (ICU).
- Conditions
- Dietary Supplements, Intensive Care Unit, Vitamin D Deficiency, Vitamin D Toxicity
- Trial name
- NCT04915963
- Testing
- Vitamin D supplementation
- Volunteers
- 340 people
- Sponsor
- Association Tunisienne d'Etude & de Recherche sur l'Athérosclérose
Respiratory Insufficiency, Pneumonia, Aspiration
Feeding Children Nasogastrically Versus Nasojejunally While Receiving Noninvasive Positive Pressure Ventilation
The investigators are studying whether it is safe and effective to provide enteral nutrition to critically ill children via the nasogastric route, as opposed to the nasojejunal route, while they are receiving noninvasive positive…
- Conditions
- Respiratory Insufficiency, Pneumonia, Aspiration, Nutrition Disorders
- Trial name
- FeedNIV (NCT01301352)
- Testing
- Route of feeding (nasogastric vs. nasojejunal)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Epidemiology, Sars-CoV2
French Single Centre Experience of Critically Ill Patients With Covid 19
Since the outbreak of a syndrome of acute respiratory distress associated to a novel coronavirus 2 (SARS-Cov2) that began in China, Europe and France have to face a sanitary emergency with critically care support when the patient…
- Conditions
- Epidemiology, Sars-CoV2, COVID 19, Critical Care
- Trial name
- CovidAmiens20 (NCT04354558)
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Sepsis, Critical Illness
Metabolic and Functional Study of γδ T Cells in Critically Ill Patients
This prospective observational cohort study investigates the subset-specific metabolic adaptation and functional remodeling of cytotoxic γδ T cells in critically ill patients with and without sepsis.
- Conditions
- Sepsis, Critical Illness, Immunosuppression, MODS
- Trial name
- NCT07680816
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Parenteral Nutrition, Gastroparesis
Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction
Clear study hypothesis / research question It has already been proven that a prolonged negative energy balance during intensive care stay is an independent risk factor for mortality.
- Conditions
- Parenteral Nutrition, Gastroparesis, Gastrointestinal Dysfunction, Protein Deficiency
- Trial name
- ATTAINMENT (NCT06510348)
- Testing
- Supplemental Parenteral Nutrition (SPN)
- Where
- Romania
- Volunteers
- 164 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Sepsis, Obstructive Shock
Use of Renin Versus Lactic Acid as Tissue Perfusion Biomarkers for Mortality Prediction in Hypotensive Critically Ill Patients
Measurement of Whole Blood Lactate Concentrations Whole blood lactate concentrations will be measured at the time of study enrollment and at 24, 48, and 72 hours.
- Conditions
- Sepsis, Obstructive Shock, Critical Illness, Hypotensive
- Trial name
- NCT05810415
- Testing
- Renin levels and lactic acid levels
- Where
- 2 sites in Egypt
- Volunteers
- 84 people
- Sponsor
- Al-Azhar University
Intestinal Ischemia, Critical Illness
Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients
This study aims to address the challenges of enteral nutrition support in critically ill ICU patients with varying gastrointestinal function.
- Conditions
- Intestinal Ischemia, Critical Illness, Enteral Nutrition Feeding, Hemodynamics
- Trial name
- NCT07001943
- Testing
- enteral nutrition
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Pain, Pain Management
Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustments
Both severe pain and opioid therapy are associated with negative effects. The experience of pain is common in the intensive care unit, but it is highly individual and difficult to assess, as patients are often unable to…
- Conditions
- Pain, Pain Management, Critical Illness
- Trial name
- INVISIBLE (NCT07473115)
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Delirium, Critical Illness
Neuroinflammation During ICU-associated Delirium in Critically Ill Patients and Its Association With Structural and Functional Brain Alterations: a Nested Case-control Study
With the present study, the authors aim to improve the knowledge of the pathophysiology of ICU-related delirium. In particular, the authors would like to clarify the possible correlation between neuroinflammation, evaluated…
- Trial name
- Delirium-fMRI (NCT04078503)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Delirium, Alteration of Cognitive Function
Early Occupational Therapy for Delirium Prevention in Older Patients Admitted to Critical Care Unit
This is a randomized, controlled trial to compare the efficacy of two strategies of non-pharmacological prevention of delirium in critically non-ventilated older patients: standard non-pharmacological prevention intensive…
- Conditions
- Delirium, Alteration of Cognitive Function, Incompetence, Functional
- Trial name
- NCT01555996
- Testing
- Early and Intensive Occupational Therapy, Standard non-pharmacological delirium prevention
- Where
- Chile
- Volunteers
- 126 people
- Sponsor
- University of Chile
Critical Illness, Acute Kidney Injury
The Association of Protein-Energy Adequacy With Mortality in Critically Ill Patients With Acute Kidney Injury.
This is a prospective observational single-center study in which the association of Protein-Energy Adequacy and 28-Days of Mortality among critically ill patients with Acute Kidney Injury, AKI will be investigated.
- Trial name
- NCT04533100
- Where
- Malaysia
- Volunteers
- 185 people
- Sponsor
- University of Malaya
Critical Illness, Respiratory Failure
Treatment of Muscle Weakness in Critically Ill Patients
Patients who are admitted to the intensive care unit and require mechanical ventilation frequently develop profound respiratory and limb muscle weakness.
- Conditions
- Critical Illness, Respiratory Failure, Myopathy, Weakness
- Trial name
- NCT02247895
- Testing
- Electrical stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gerald Supinski
Enteral Feeding Intolerance, Critical Illness
Continuous Versus Intermittent Enteral Feeding and Gastric Residual Volume in Critically Ill Patients
This study will compare two commonly used methods of enteral feeding in critically ill adults: continuous feeding and intermittent feeding.
- Trial name
- NCT07876141
- Testing
- Continuous Enteral Feeding, Intermittent Enteral Feeding
- Where
- Vietnam
- Volunteers
- 76 people
- Sponsor
- Viet Duc University Hospital
Critical Care, Rehabilitation
Differences in Frail and Non-frail Critically-ill Patients in Functional Outcomes
This is a prospective analysis of patient registry data of intensive care patients. The aim is to investigate if frailty is a predictor of decline of functional status of critically ill patients during their hospital stay.
- Conditions
- Critical Care, Rehabilitation, Outcome Assessment, Critical Illness
- Trial name
- DEFAULT (NCT03789305)
- Where
- Germany
- Volunteers
- 731 people
- Sponsor
- Technical University of Munich
Critically Ill, Hemodynamic Instability
Comparing the PiCCO Monitor to the Non-invasive Biobeat (BB)-316PW in ICU Patients
The aim of this study is to compare hemodynamic monitoring using the invasive PiCCO device to the BB-613PW wireless, non-invasive PPG-based device, in critically ill patients within the ICU, suffering from hemodynamic instability…
- Trial name
- NCT04215627
- Testing
- non-invasive monitoring
- Where
- Israel
- Volunteers
- 9 people
- Sponsor
- Biobeat Technologies Ltd.
Acute Kidney Injury, ARDS
Pilot Study on HA380 Column Use in Critically Ill Patients Receiving Extracorporeal Support.
Patients who are very ill either due to a severe infection, major organ injury, trauma or a major operation may require significant support with devices such as a dialysis machine for the kidneys or Extracorporeal Membrane…
- Conditions
- Acute Kidney Injury, ARDS, Inflammation, Extracorporeal Circulation; Complications
- Trial name
- HACEC (NCT06179771)
- Testing
- HA 380
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University Hospitals, Leicester
Critical Illness, Metabolism Disorders
The Blood-Interstitial Glucose Gap
Metabolic monitoring is fundamental to guiding nutritional therapy in critically ill patients. Although indirect calorimetry is the established gold standard for measuring resting energy expenditure, its routine clinical use is…
- Trial name
- NCT07251764
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Chinese Medical Association
Methicillin-resistant Staphylococcus Aureus, Sepsis
Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project
Determine if a cystatin C-inclusive vancomycin dosing algorithm improved target trough achievement compared to creatinine clearance-guided vancomycin therapy in critically ill patients.
- Conditions
- Methicillin-resistant Staphylococcus Aureus, Sepsis, Critical Illness
- Trial name
- NCT02945241
- Testing
- Vancomycin, Cystatin C dosing algorithm, Creatine clearance dosing algorithm
- Volunteers
- 399 people
- Sponsor
- Mayo Clinic
ARDS, Sepsis
Drug Monitoring of Antibiotics in Critical Care Patients
Infections are critical factors for the survival of critically ill patients. A broad, high-dose and early initial therapy of antibiotics is of particular relevance.
- Trial name
- DRAK (NCT01793012)
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Acute Lung Injury, Transfusion Related
Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury
TRALI was defined as "acute noncardiogenic pulmonary edema typically occurs ≤ 6 hours following transfusion of plasma-containing blood products, such as packed red blood cells, fresh frozen plasma, platelets, or cryoprecipitate."…
- Trial name
- ASTRALI (NCT04153487)
- Testing
- Ascorbic Acid Injectable Product
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Damanhour University