Clinical trials: Critical Ill Patients
Gastrointestinal Dysfunction, Critical Illness
Association Between SMA Flow and AGI in Critically Ill Patients
Acute gastrointestinal injury (AGI) is related to poor outcomes of critically ill patients [1] through many underlying mechanisms [2]. It is also a part of the process of multiple organ dysfunction syndrome (MODS).
- Trial name
- NCT04979494
- Testing
- ultrasound examination
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Xinchen Wang
Critically Ill, Sepsis
Clinical Outcomes Of Mega-dosage Supplementations Of Cholecalciferol In Critically Ill Patients With Sepsis
Non-COVID-19 sepsis (Sepsis) has always been one of the common diseases in critically ill patients. The main treatment strategy is to kill pathogens and mitigate hyperinflammation.
- Conditions
- Critically Ill, Sepsis, Mortality Rate, Critical Care
- Trial name
- MDC-S (NCT06447441)
- Testing
- Cholecalciferol
- Volunteers
- 240 people
- Sponsor
- Chimei Medical Center
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
Acute Kidney Disease
Renal Outcome of Acute Kidney Disease
Both, acute kidney injury (AKI) and chronic kidney disease (CKD) considered as a continuum of the disease process. The renal recovery after AKI is currently assessed by measuring serum creatinine, which has its limitations…
- Trial name
- NCT03597854
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Critically Ill, Cardiac Disease
Respired Gases in Patients Post Cardiac Surgery
Certain diseases relating to the heart can only be definitively treated with surgery. When untreated, these can lead to heart failure with a lack of supply of oxygen-rich blood to the tissues, leading to damage to other organs.
- Conditions
- Critically Ill, Cardiac Disease, Mitral Valve Disease
- Trial name
- REGAPS (NCT05531253)
- Testing
- Data collection using the Optical Gas Analyser
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Oxford
Renal Insufficiency
Dalteparin's Influence on Renally Compromised: Anti-Ten-A Study (DIRECT)
The investigators' primary research objective is: To determine the safety of dalteparin prophylaxis, 5,000 IU once-daily, in Intensive Care Unit (ICU) patients based on: the proportion of patients with trough anti-Xa > 0.40 IU/mL…
- Trial name
- NCT00138099
- Testing
- Fragmin (dalteparin sodium)
- Where
- 14 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Hamilton Health Sciences Corporation
Critical Illness
Intravenous Fish Oil Emulsion in Critically Ill Patients With High Inflammatory Status.
Critically ill patients can develop high levels of inflammation, which may contribute to organ damage, muscle loss, and difficulty recovering physical function.
- Trial name
- FOiL-INFLAMe (NCT07883447)
- Testing
- Omegaven (10% fish-oil emulsion; Fresenius-Kabi)
- Where
- Malaysia
- Volunteers
- 159 people
- Sponsor
- Lee Zheng Yii
Critical Illness, Bacterial Infections
PK/PD and Clinial Outcomes of Beta-lactams in ICU Patients
Meropenem and imipenem are broad-spectrum carbapenem antibiotic and are frequently prescribed in critically ill patients with severe infections.
- Trial name
- NCT03858387
- Testing
- Meropenem, Imipenem
- Where
- Thailand
- Volunteers
- 102 people
- Sponsor
- Prince of Songkla University
Critical Illness, Obesity
Indirect Calorimetry Guided Energy Provision in Critically Ill Patients With Obesity
The DIRECT trial is a prospective, multi-centre, two arm parallel feasibility pilot randomised controlled trial. The primary aim is to determine the feasibility of using repeat indirect calorimetry measurements to direct energy…
- Trial name
- DIRECT (NCT06053216)
- Testing
- Indirect calorimetry, Indirect calorimetry (Standard care nutrition arm)
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 60 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critical Illness
POCUS AI in Critically Ill Patients
This is a prospective study that aims to assess the differences in point-of-care ultrasound assessment (POCUS) with portable and ultra-portable devices, using conventional vs artificial intelligence (AI) methodologies, performed…
- Trial name
- PocusAI-Crit (NCT05336448)
- Where
- Portugal
- Volunteers
- 99 people
- Sponsor
- Hospital Garcia de Orta
Critical Illness, Enteral Nutrition
Trial of Enteral Glutamine on Intestinal Permeability in Critically Ill Patients
Glutamine-induced recovery in intestinal barrier function by reducing bacterial translocation was demonstrated in previous studies.
- Conditions
- Critical Illness, Enteral Nutrition, Intestinal Permeability
- Trial name
- NCT03113240
- Testing
- Glutamin, Maltodextrin
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University
Vitamin D Deficiency, Hyperparathyroidism
Abnormally High Parathyroid Hormone Levels Worsens Outcomes in Vitamin D Depleted Critical Care Patients
This study aims to investigate the impacts of abnormally elevated PTH levels on clinical outcomes among critically ill patients with vitamin D depletion.
- Conditions
- Vitamin D Deficiency, Hyperparathyroidism, Critically Ill Patients Admitted in ICU
- Trial name
- NCT06711874
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Taiwan University Hospital
Critically Ill, Intensive Care Unit
High Protein Formula on Enteral Feeding in Clinical Improvement and Malnutrition at Intensive Care Unit Patients
Effectiveness of Early Enteral Feeding With High Protein Polymeric Formula Versus Oligomeric Formula Versus 5% Dextrose Solution in Clinical Improvement and Malnutrition on Intensive Care Unit Patients Background : Critically ill…
- Trial name
- NCT04150978
- Testing
- High Protein Polymeric Formula, Oligomeric Formula, 5% Dextrose
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Hasanuddin University
Acute Kidney Injury, Critically Ill
Ultrasound to Evaluate Acute Kidney Injury
Acute kidney injury is a common complication in critically ill patients. This condition can significantly prolong the length of hospital stay, increase the cost of hospitalization, and have a high mortality rate and a poor…
- Trial name
- NCT06241417
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Southeast University, China
Acute Kidney Injury, Critical Illness
Preventing Acute Kidney Injury and Improving Outcome in Critically Ill Patients Utilising Risk Prediction Score
An interventional controlled trial to test the feasibility of applying risk score based prevention for critically ill patient at high risk to develop acute kidney injury (AKI)
- Trial name
- PRAIOC-RISKS (NCT03178435)
- Testing
- Measures to prevent AKI among critically ill patients
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Kasr El Aini Hospital
Tracheostomized Patients, Mechanical Ventilation Weaning
High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients
In this pilot randomized controlled trial (RCT), the investigators aim to explore the feasibility of conducting a powered RCT that examines the efficacy and safety of high flow tracheal oxygen (HFTO) in weaning critically ill…
- Conditions
- Tracheostomized Patients, Mechanical Ventilation Weaning, High Flow Oxygen Therapy
- Trial name
- HFTO-WEAN (NCT07559591)
- Testing
- High-flow tracheal oxygen (HFTO), Tracheal Mask (TM)
- Where
- Saudi Arabia
- Volunteers
- 88 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Positive-Pressure Respiration, Intrinsic, Critically Ill Patients
A New Monitor to Measure Dermal Blood Flow in Critically Ill Patients: a Preliminary Study
Background: Conditions of reduced perfusion are characterized by redistribution of blood flow away from the skin to more vital organs.
- Trial name
- MDBF-CIP (NCT01794468)
- Testing
- Dermal blood flow measurements
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Rabin Medical Center
Traumatic Brain Injury
TBI-Prognosis Multicenter Prospective Study
Severe traumatic brain injury (TBI) is the leading cause of death and disability among people under 45 years of age and a major public health problem.
- Trial name
- NCT02452541
- Testing
- Prognostic tests
- Where
- 17 sites in Canada
- Volunteers
- 315 people
- Sponsor
- CHU de Quebec-Universite Laval
Acute Kidney Injury, COVID-19
Incidence of Acute Kidney Injury in Covid-19
Acute kidney injury (AKI) in Covid-19 patients is a topic that receives little attention in the literature, although being important in clinical practice in the ICU, particularly in Oman.
- Conditions
- Acute Kidney Injury, COVID-19, Critically Ill
- Trial name
- COVIDAKI (NCT05467956)
- Testing
- Covid-19
- Where
- Oman
- Volunteers
- 286 people
- Sponsor
- Sultan Qaboos University
Critically Ill
Salivary Cortisol in Intensive Care Unit
In critical illness, patients are highly stressed and should have elevated cortisol (stress hormone) secretion to adapt to stress.
- Trial name
- NCT02001207
- Testing
- Salivary cortisol test
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital