Clinical trials: Critical Ill Patients
Respiratory Failure, Critical Illness
Combining Chest X-Ray and Arterial Blood Gas Findings to Predict Need for Mechanical Ventilation in Critically Ill Patients
This prospective cross-sectional study aims to develop and validate a machine learning model that combines chest X-ray findings with arterial blood gas (ABG) analysis to assess the necessity for mechanical ventilation in…
- Conditions
- Respiratory Failure, Critical Illness, Mechanical Ventilation
- Trial name
- NCT07001696
- Where
- Egypt
- Volunteers
- 2,160 people
- Sponsor
- Zagazig University
Anxiety, Pain
Assessing the Impact of LIve Music in the Intensive Care Unit (ICU) to Improve Care for Critically Ill Patients
Noise in the ICU can worsen patient outcomes through factors such as increased cardiovascular stress, alteration in sleep, and increased discomfort or pain The purpose of this study is to determine the benefit of therapeutic…
- Conditions
- Anxiety, Pain, Critical Illness, Relaxation
- Trial name
- NCT03948984
- Testing
- Therapeutic Music Session
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Vanderbilt University Medical Center
Glucose Metabolism Disorders, Diabetic Blood Glucose Monitoring
Accuracy, Feasibility and Acceptance of Continuous Glucose Monitoring in Critically Ill Patients
Critically ill patients are on high risk for increased serum glucose levels, leading to more comorbidity and higher mortality risk. In patients with severe sepsis and septic shock hyperglycemia is a typical finding.
- Conditions
- Glucose Metabolism Disorders, Diabetic Blood Glucose Monitoring, Critical Illness
- Trial name
- NCT02296372
- Testing
- Continuous glucose monitoring
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Critical Illness, Nutritional Imbalance
Energy and Protein Adequacy of Oral Intake After Ventilator Withdrawal Among Critically Ill Patients.
The aim of this study is to evaluate the adequacy of exclusive oral intake, in terms of energy-protein amount, after extubation in critically ill patients who remained on invasive mechanical ventilation for at least 48 hours.
- Trial name
- NCT05548400
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Critical Illness
Lormetazepam Versus Midazolam in Critically Ill Patients: a Retrospective Cohort Trial
The aim of this retrospective cohort study is to evaluate the effect of lormetazepam versus midazolam on hospital mortality, intensive care unit outcomes and sedation management.
- Trial name
- RetroLoveMi (NCT04408911)
- Testing
- Midazolam vs. Lormetazepam
- Volunteers
- 3,314 people
- Sponsor
- Charite University, Berlin, Germany
Initial Phase of Severe Sepsis and Septic Shock
Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem During the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units
This is a prospective, noncomparative study to assess the pharmacodynamics of meropenem during early phase of severe sepsis and septic shock in critically ill patients in an intensive care unit.
- Trial name
- NCT02213796
- Testing
- Meropenem
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Sutep Jaruratanasirikul
Sepsis, Septic Shock
Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients.
Infections in critically ill patients are a major healthcare problem and an important source of morbidity and mortality. Since critically ill patients often have altered pharmacokinetics (PK) compared to non-critically ill…
- Conditions
- Sepsis, Septic Shock, Infection, Bacterial, Critically Ill
- Trial name
- PHARAOH (NCT04470973)
- Testing
- Cefuroxime, Amikacin
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Burns, Critical Illness
Indirect Calorimetry in Patients at Risk of Malnutrition
Burn patients treated in an outpatient clinic and ICU survivors are at risk of malnutrition. There are no clear guidelines determining the energy target in those two populations.
- Conditions
- Burns, Critical Illness, Indirect Calorimetry, Resting Energy Expenditure
- Trial name
- NCT04500483
- Testing
- indirect calorimetry
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University of Liege
Critical Illness, Enteral Nutrition
Optimizing Enteral Nutrition Regimen for Critically Ill Patients
Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube…
- Conditions
- Critical Illness, Enteral Nutrition, Ventilator Associated Pneumonia, Hyperglycemia
- Trial name
- NCT07270939
- Testing
- 20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window, 18-Hour Cycled Enteral Nutrition with a 6-Hour Fasting Window
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Critical Illness, Intensive Care
Early Exercise Training in Critically Ill Patients
This randomized controlled trial was designed to investigate whether a daily training session using a bedside cycle ergometer, started early in stable critically ill patients with an expected prolonged ICU stay, could induce a…
- Conditions
- Critical Illness, Intensive Care, Muscle Weakness, Deconditioning
- Trial name
- NCT00695383
- Testing
- Bedside cycle exercise therapy, Standard physiotherapy program
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
Enteral and Supplement Feeds Adverse Reaction, Nutrition Deficiency Due to Insufficient Food
How Well do we Feed the Critically Ill Patients
The present prospective observational multicentric study will assess the nutritional status of critically ill patients, cumulative calorie and protein balance and the effect of calorie and protein balance on clinical outcomes.
- Conditions
- Enteral and Supplement Feeds Adverse Reaction, Nutrition Deficiency Due to Insufficient Food, Critically Ill, Parenteral Nutrition Associated Liver Disease
- Trial name
- WE-FEED (NCT05347888)
- Testing
- Nutritional therapy
- Where
- United Arab Emirates
- Volunteers
- 1,000 people
- Sponsor
- NMC Specialty Hospital
Critically Ill, Mechanically Ventilated
Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation
The aim of this study is to evaluate the effect of early activity and mobilisation during prolonged IMV on the composite outcome "days alive and out of hospital to day 180".
- Trial name
- TEAM(III) (NCT03133377)
- Testing
- Early activity and mobilisation
- Where
- 49 sites in Australia, Germany and 3 more
- Volunteers
- 750 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Nutrition, Critical Illness
Nutritional Status of Critically Ill Diabetic Patients
1. To investigate the nutritional status of patients with type 2 diabetes mellitus in the intensive care unit. 2. To detect the impact of nutritional status on outcome (mortality, length of hospital stay,duration of mechanical…
- Conditions
- Nutrition, Critical Illness, Diabetes Mellitus, Type 2
- Trial name
- NCT06564168
- Volunteers
- 430 people
- Sponsor
- Assiut University
Stress Disorders, Post-Traumatic, Depression
Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on PTSD
Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation.
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety
- Trial name
- NCT02040649
- Testing
- Non-sedation, Control, sedation (propofol, midazolam)
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Palle Toft
Bacterial Infection, Critically Ill
Study of Tigecycline Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy(CRRT)
The aim of this study is to determine the Pharmacokinetics/Pharmacodynamics(PK/PD) of tigecycline in critical ill patients undergoing continuous renal replacement therapy（CRRT）and examine whether the dosage needs adjustment.
- Trial name
- NCT02931526
- Testing
- Tigecycline
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Early Mobilization, Critically Ill
Effect of Early Extracorporeal Diaphragm Pacing Combined With Tilt Table in Ventilated Patients.
The aim of this study is to test the effect of 1week of extracorporeal diaphragm pacing (EDP) combined either with or without tilt table verticalization (TTV) on diaphragm function in patients with mechanical ventilation compared…
- Conditions
- Early Mobilization, Critically Ill, Mechanical Ventilation, Diaphragm Dysfunction
- Trial name
- NCT05953649
- Testing
- Extracorporeal Diaphragm Pacing, Tilt Table Verticalization, Conventional Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Tracheal Intubation Morbidity, Critical Care
Nasotracheal Intubation in Critically Ill.
The aim of this prospective randomized trail is to compare nasotracheal versus orotracheal intubation in critically ill patients.
- Trial name
- NaTra-P (NCT05780385)
- Testing
- nasotracheal intubation, orotracheal intubation
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Critically Ill
Hypocaloric Nutrition in Critically Ill Patients
The aim of this study is to compare two nutritional regimes in critically ill patients. Patients will be randomized to standard care (25 kcal per kg) or to hypocaloric nutrition (15 kcal per kg).
- Trial name
- RuRaL (NCT01531335)
- Testing
- Hypocaloric hyperproteic nutrition, Standard care
- Where
- Colombia
- Volunteers
- 80 people
- Sponsor
- Lafrancol S.A.
Critical Illness, Self-Assessment
Comparison of Self-assessment vs. Assessment by Others of Critically Ill Patients
We will test the results of standardized questionnaires for patients admitted to intensive care assessed by relatives/caregivers compared to the patient itself.
- Conditions
- Critical Illness, Self-Assessment, Assessment, Self
- Trial name
- ASTON (NCT03785444)
- Testing
- WHODAS 2.0, EQ5D, IADL
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Kidney Failure, Acute, Critical Illness
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated.
- Trial name
- NCT00316576
- Testing
- Blood sampling for PCR
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Caen