Clinical trials: Critical Ill Patients
Thoracic Surgery, Cardiac Surgery
Comparison of Two Potassium Targets Within the Normal Range in Intensive Care Patients
Rationale: It is well known that distinctly abnormal blood potassium values can cause serious complications such as cardiac arrhythmias.
- Conditions
- Thoracic Surgery, Cardiac Surgery, Critically Ill
- Trial name
- GRIP-COMPASS (NCT01085071)
- Testing
- Potassium Chloride
- Where
- Netherlands
- Volunteers
- 1,225 people
- Sponsor
- University Medical Center Groningen
Acute Respiratory Failure, Encephalopathy
Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment
This study evaluates a novel arm restraint compared with traditional soft wrist restraints in older critically ill patients. The primary outcome is upper extremity mobility measured by actigraphy, and secondary outcomes include…
- Conditions
- Acute Respiratory Failure, Encephalopathy, ARDS, Sepsis
- Trial name
- NCT04067622
- Testing
- Exersides
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Vermont
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)
Retrospective observational cohort study including all patients admitted for toxidermia (Lyell syndrome, Stevens-Johnson Syndrome (SJS), or other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn…
- Trial name
- TEN metabolism (NCT05320653)
- Testing
- Medical nutrition
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sleep Disturbance, Delirium
Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients
Sleep disturbance is very common among critically ill patients in the intensive care unit (ICU), particularly in older adults after surgery.
- Conditions
- Sleep Disturbance, Delirium, Critical Illness
- Trial name
- NCT07407400
- Testing
- Lemborexant
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Pressure Sores, Intensive Care
The Effect of Antioxidants on the Immune Response and Wound Healing in Critically Ill Patients
The purpose of this study is to investigate whether the addition of omega-3 and antioxidants to nutritional support in critically ill patients in the intensive care unit influences the immune and anti-inflammatory systems and so…
- Trial name
- NCT00487097
- Testing
- Eicosapentanoic acid, docosahexaenoic acid
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Therapeutic Drug Monitoring, Critical Illness
Pharmacokinetic of Posaconazole in Critically Ill Patients
The posaconazole pharmacokinetic in critically ill patients will be studied in a prospective, non-interventional, monocentric observational trial.
- Trial name
- NCT05275179
- Testing
- Posaconazole Therapeutic Drug Monitoring
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Critical Illness
Feasibility Study on Implementing Consultation-based High-quality Palliative Care Services in Intensive Care Units
Critically ill patients in intensive care units (ICUs) receive life-sustaining treatments aimed at restoring or maintaining organ function.
- Trial name
- NCT06490835
- Testing
- High-quality palliative care through consultation-based palliative care services in the ICU
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Intensive Care Unit, Invasive Mechanical Ventilation
Determination of the Optimal Spontaneous Breathing Trial During Weaning of Mechanical Ventilation
Assessment and comparison of three spontaneous breathing trials in five specific profiles of intensive care unit and perioperative patients. A physiological cross over study
- Conditions
- Intensive Care Unit, Invasive Mechanical Ventilation, Ready to Wean From Ventilation
- Trial name
- GLOBAL WEAN (NCT04222569)
- Testing
- T-piece, PSV 7 and PEEP 0, PSV 0 and PEEP 0
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Montpellier
Critical Illness, Transportation Accidents
Intra-Hospital Transport of Critically Ill Patients in Intensive Care Unit
Intra-hospital transport is a frequent procedure in the ICU, involving patients with the highest severity scores. Although some studies estimate the rate of adverse events to be around 33% during intra-hospital transport…
- Conditions
- Critical Illness, Transportation Accidents, Intensive Care Unit
- Trial name
- TIGRHOU (NCT06455696)
- Where
- France
- Volunteers
- 645 people
- Sponsor
- French Society for Intensive Care
Left Ventricular Dysfunction, Critically Ill
Left Ventricular Dysfunction in Critically Ill Patients
Left ventricular dysfunction is common in the critically ill. The aim of this study is to assess the incidence and prognosis of left ventricular dysfunction in critically ill patients.
- Conditions
- Left Ventricular Dysfunction, Critically Ill, Acute Coronary Syndrome, Cardiomyopathies
- Trial name
- LEVEDYCIP (NCT03787810)
- Testing
- Echocardiography
- Where
- Sweden
- Volunteers
- 428 people
- Sponsor
- Sahlgrenska University Hospital
Patient Centered Care, Postoperative Care
Outreach: A Programme for Timely Treatment of Critically Ill Patients in a University Hospital
The identification of patients with potential early organ failure is the key in preventing admission or readmission to a critical care facility.
- Conditions
- Patient Centered Care, Postoperative Care, Critical Illness
- Trial name
- NCT00306345
- Testing
- Outreach
- Where
- Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Radboud University Medical Center
Critically Ill
Enteral Versus Parenteral Glutamine Supplement
Glutamine is a major fuel for the intestinal tract and immune cells and therefore affects the intestinal permeability (IP) and infection rate at critically ill patients.
- Trial name
- NCT00875797
- Testing
- parenteral glutamine, enteral glutamine
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Burns
Timing of Surgery And Outcome in Burn Patients ( EARLYBURN )
The prognostic of burn patients has improved over the last decades. Early excision of full thickness burns is thought to be one of the key factors which have led to prognostic improvement.
- Trial name
- EARLYBURN (NCT02940171)
- Testing
- Early Excision of full thickness burn, Late Excision of full thickness burn
- Where
- France
- Volunteers
- 470 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Electrolyte Imbalance, Volume Overload
The Enteral Resuscitation In Intensive Care Pilot- Study
The purpose of this pilot study is to overcome the limited evidence on enteral fluid administration in intensive care medicine and to generate data for further hypothesis generation in an exploratory setting.
- Conditions
- Electrolyte Imbalance, Volume Overload, Hyperosmolality
- Trial name
- ERI (NCT05595395)
- Testing
- Enteral Dose Form, Intravenous Infusion
- Where
- 2 sites in Austria
- Volunteers
- 64 people
- Sponsor
- Medical University of Vienna
Critical Illness
Study on the Measurement Method of the Left Diaphragm
This study intends to use ultrasound to measure the bilateral diaphragmatic ultrasound indicators in critically ill patients, focusing on the left diaphragm, and to explore the consistency and reliability among various ultrasound…
- Trial name
- LD (NCT07559669)
- Volunteers
- 35 people
- Sponsor
- Shanghai Zhongshan Hospital
Diarrhea Caused by Drug, Clostridium Difficile Infections
Faecal Bacteriotherapy for Postantibiotic Diarrhoea in Critically Ill Patients
Rationale: Postantibiotic diarrhoea in critically ill patients is common, often prolonged and currently there is no effective treatment of it.
- Trial name
- FEBATRICE (NCT05430269)
- Testing
- Faecal bacteriotherapy (FBT), standard-of-care protocolised treatment of postantibiotic diarhea
- Where
- 2 sites in Czechia
- Volunteers
- 36 people
- Sponsor
- Charles University, Czech Republic
Sarcopenia, Stroke, Acute
Effects of Mobility Dose on Discharge Disposition in Critically Ill Stroke Patients
The primary aim of the study is to assess the mobility dose in neurocritical care patients with ischemic stroke or intracranial hemorrhage and its effects on discharge disposition and patient outcomes.
- Conditions
- Sarcopenia, Stroke, Acute, Muscle Weakness, Critical Illness
- Trial name
- NCT03347656
- Where
- 3 sites in United States, Germany
- Volunteers
- 164 people
- Sponsor
- Beth Israel Deaconess Medical Center
Malnutrition in Pregnancy, Malnutrition; Protein
Value of Early Postoperative Peptide-based Formula in Critically Ill Obstetrics on Recovery Enhancement
This is the first trial to assess the early semi-elemental postoperative formula load to meet the protein requirements in the first and second day postoperative to enhance the recovery of critically ill parturient (value on ERAS…
- Conditions
- Malnutrition in Pregnancy, Malnutrition; Protein, Postpartum Disorder, Patient Satisfaction
- Trial name
- NCT06164301
- Testing
- Elemental amino-acids
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Ain Shams University
Psychological Disorder, Critical Illness
Feasibility and Preliminary Effects of a Spiritual Care Strategy on Psychological Disorders in Critically Ill Patients
Studies in hospitalized patients have shown that a large percentage of them consider religion or spirituality to be an important factor in enabling them to cope with a serious illness.
- Trial name
- NCT06048783
- Testing
- Program of systematic and periodic spiritual accompaniment and care
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Critical Illness
Hemodynamic Variations During Remote Ischemic Conditioning in Critical Ill Patients
The main objectives of this study are to evaluate the changes in hemodynamics occurring during the remote ischemic conditioning (RIC) procedure and to compare the hemodynamic responses elicited by passive leg raising before and…
- Trial name
- HERICA (NCT06536231)
- Testing
- Remote ischemic conditioning
- Where
- Lithuania
- Volunteers
- 50 people
- Sponsor
- Lithuanian University of Health Sciences